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Subsystem: Folate metabolism Remove
1–50 of 64 reactions in Folate metabolism
dihydrobiopterin[c] + H+[c] + NADH[c] = NAD+[c] + tetrahydrobiopterin[c]
ReversibleBalancedEC 1.5.1.34Human-GEM MAR03925
5,10-methenyl-THF[c] + NH3[c] = 5-formiminotetrahydrofolate[c] + H+[c]
ReversibleBalancedEC 4.3.1.4Human-GEM MAR03929
formaldehyde[c] + THF[c] = 5,10-methylene-THF[c] + H2O[c]
Left to rightBalancedHuman-GEM MAR03972
dihydrofolate[c] + H+[c] + NADH[c] = NAD+[c] + THF[c]
ReversibleBalancedEC 1.5.1.3Human-GEM MAR04332
dihydrofolate[c] + H+[c] + NADPH[c] = NADP+[c] + THF[c]
ReversibleBalancedEC 1.5.1.3Human-GEM MAR04333
dihydrofolate[m] + H+[m] + NADPH[m] = NADP+[m] + THF[m]
ReversibleBalancedEC 1.5.1.3Human-GEM MAR04335
10-formyl-THF[c] + H2O[c] + NADP+[c] = CO2[c] + H+[c] + NADPH[c] + THF[c]
Left to rightBalancedEC 1.5.1.6Human-GEM MAR04336
ATP[c] + formate[c] + THF[c] = 10-formyl-THF[c] + ADP[c] + Pi[c]
Left to rightBalancedEC 3.5.4.9, 6.3.4.3Human-GEM MAR04338
ATP[m] + formate[m] + THF[m] = 10-formyl-THF[m] + ADP[m] + Pi[m]
Left to rightBalancedEC 3.5.4.9, 6.3.4.3Human-GEM MAR04340
5,10-methenyl-THF[m] + NADH[m] = 5,10-methylene-THF[m] + NAD+[m]
ReversibleBalancedEC 1.5.1.15Human-GEM MAR04440
5,10-methenyl-THF[c] + NADPH[c] = 5,10-methylene-THF[c] + NADP+[c]
ReversibleBalancedEC 1.5.1.5Human-GEM MAR04442
5,10-methenyl-THF[m] + NADPH[m] = 5,10-methylene-THF[m] + NADP+[m]
ReversibleBalancedEC 1.5.1.5Human-GEM MAR04444
5,10-methylene-THF[c] + 2 H+[c] + NADPH[c] = 5-methyl-THF[c] + NADP+[c]
Left to rightBalancedEC 1.5.1.20Human-GEM MAR04446
5,10-methylene-THF[c] + 2 H+[c] + NADH[c] = 5-methyl-THF[c] + NAD+[c]
Left to rightBalancedEC 1.5.1.20Human-GEM MAR04448
10-formyl-THF[c] + H+[c] = 5,10-methenyl-THF[c] + H2O[c]
ReversibleBalancedEC 3.5.4.9Human-GEM MAR04503
10-formyl-THF[m] + H+[m] = 5,10-methenyl-THF[m] + H2O[m]
ReversibleBalancedEC 3.5.4.9Human-GEM MAR04505
folate[c] + NADH[c] = dihydrofolate[c] + NAD+[c]
ReversibleBalancedEC 1.5.1.3Human-GEM MAR04654
folate[c] + NADPH[c] = dihydrofolate[c] + NADP+[c]
ReversibleBalancedEC 1.5.1.3Human-GEM MAR04655
folate[m] + NADPH[m] = dihydrofolate[m] + NADP+[m]
Left to rightBalancedEC 1.5.1.3Human-GEM MAR04656
5,10-methenyl-THF[m] + H2O[m] = 5-formyl-THF[m] + H+[m]
Left to rightBalancedEC 2.1.2.10Human-GEM MAR04665
5-formyl-THF[m] + ATP[m] = 5,10-methenyl-THF[m] + ADP[m] + Pi[m]
Left to rightBalancedEC 6.3.3.2Human-GEM MAR04666
GTP[c] + H2O[c] = cPMP[c] + PPi[c]
Left to rightBalancedEC 4.1.99.22, 4.6.1.17Human-GEM MAR07145
cPMP[c] + 7 H+[c] + 8 NADPH[c] + 2 PAPS[c] = 8 H2O[c] + molybdopterin[c] + 8 NADP+[c] + 2 PAP[c]
Left to rightBalancedEC 2.8.1.12Human-GEM MAR07146
ATP[c] + H+[c] + molybdopterin[c] = adenylated molybdopterin[c] + PPi[c]
Left to rightBalancedEC 2.7.7.75Human-GEM MAR07147
10-formyl-THF[c] + 4 ATP[c] + 4 glutamate[c] = 10-formyl-THF-glu(5)[c] + 4 ADP[c] + 4 H+[c] + 4 Pi[c]
Left to rightBalancedEC 6.3.2.17Human-GEM MAR07908
10-formyl-THF[m] + 4 ATP[m] + 4 glutamate[m] = 10-formyl-THF-glu(5)[m] + 4 ADP[m] + 4 H+[m] + 4 Pi[m]
Left to rightBalancedEC 6.3.2.17Human-GEM MAR07909
10-formyl-THF-glu(5)[c] + ATP[c] + glutamate[c] = 10-formyl-THF-glu(6)[c] + ADP[c] + H+[c] + Pi[c]
Left to rightBalancedEC 6.3.2.17Human-GEM MAR07910
10-formyl-THF-glu(5)[m] + ATP[m] + glutamate[m] = 10-formyl-THF-glu(6)[m] + ADP[m] + H+[m] + Pi[m]
Left to rightBalancedEC 6.3.2.17Human-GEM MAR07911
10-formyl-THF-glu(6)[c] + ATP[c] + glutamate[c] = 10-formyl-THF-glu(7)[c] + ADP[c] + H+[c] + Pi[c]
Left to rightBalancedEC 6.3.2.17Human-GEM MAR07912
10-formyl-THF-glu(6)[m] + ATP[m] + glutamate[m] = 10-formyl-THF-glu(7)[m] + ADP[m] + H+[m] + Pi[m]
Left to rightBalancedEC 6.3.2.17Human-GEM MAR07913
10-formyl-THF-glu(5)[l] + 4 H2O[l] = 10-formyl-THF[l] + 4 glutamate[l]
Left to rightBalancedEC 3.4.19.9Human-GEM MAR07916
10-formyl-THF-glu(6)[l] + H2O[l] = 10-formyl-THF-glu(5)[l] + glutamate[l]
Left to rightBalancedEC 3.4.19.9Human-GEM MAR07919
10-formyl-THF-glu(5)[e] + 4 H2O[e] = 10-formyl-THF[e] + 4 glutamate[e]
Left to rightBalancedEC 3.4.19.9Human-GEM MAR07920
10-formyl-THF-glu(6)[e] + H2O[e] = 10-formyl-THF-glu(5)[e] + glutamate[e]
Left to rightBalancedEC 3.4.19.9Human-GEM MAR07921
10-formyl-THF-glu(7)[e] + H2O[e] = 10-formyl-THF-glu(6)[e] + glutamate[e]
Left to rightBalancedEC 3.4.19.9Human-GEM MAR07922
10-formyl-THF-glu(7)[l] + H2O[l] = 10-formyl-THF-glu(6)[l] + glutamate[l]
Left to rightBalancedEC 3.4.19.9Human-GEM MAR07925
4 ATP[c] + dihydrofolate[c] + 4 glutamate[c] = 4 ADP[c] + 4 H+[c] + pentaglutamyl-folate(DHF)[c] + 4 Pi[c]
Left to rightBalancedEC 6.3.2.17Human-GEM MAR08105
ATP[c] + glutamate[c] + pentaglutamyl-folate(DHF)[c] = ADP[c] + H+[c] + hexaglutamyl-folate(DHF)[c] + Pi[c]
Left to rightBalancedEC 6.3.2.17Human-GEM MAR08106
ATP[c] + glutamate[c] + hexaglutamyl-folate(DHF)[c] = ADP[c] + H+[c] + heptaglutamyl-folate(DHF)[c] + Pi[c]
Left to rightBalancedEC 6.3.2.17Human-GEM MAR08107
4 ATP[c] + 4 glutamate[c] + THF[c] = 4 ADP[c] + 4 H+[c] + pentaglutamyl-folate(THF)[c] + 4 Pi[c]
Left to rightBalancedEC 6.3.2.17Human-GEM MAR08108
ATP[c] + glutamate[c] + pentaglutamyl-folate(THF)[c] = ADP[c] + H+[c] + hexaglutamyl-folate(THF)[c] + Pi[c]
Left to rightBalancedEC 6.3.2.17Human-GEM MAR08109
ATP[c] + glutamate[c] + hexaglutamyl-folate(THF)[c] = ADP[c] + H+[c] + heptaglutamyl-folate(THF)[c] + Pi[c]
Left to rightBalancedEC 6.3.2.17Human-GEM MAR08110
4 ATP[m] + dihydrofolate[m] + 4 glutamate[m] = 4 ADP[m] + 4 H+[m] + pentaglutamyl-folate(DHF)[m] + 4 Pi[m]
Left to rightBalancedEC 6.3.2.17Human-GEM MAR08112
ATP[m] + glutamate[m] + pentaglutamyl-folate(DHF)[m] = ADP[m] + H+[m] + hexaglutamyl-folate(DHF)[m] + Pi[m]
Left to rightBalancedEC 6.3.2.17Human-GEM MAR08113
ATP[m] + glutamate[m] + hexaglutamyl-folate(DHF)[m] = ADP[m] + H+[m] + heptaglutamyl-folate(DHF)[m] + Pi[m]
Left to rightBalancedEC 6.3.2.17Human-GEM MAR08114
4 ATP[m] + 4 glutamate[m] + THF[m] = 4 ADP[m] + 4 H+[m] + pentaglutamyl-folate(THF)[m] + 4 Pi[m]
Left to rightBalancedEC 6.3.2.17Human-GEM MAR08115
ATP[m] + glutamate[m] + pentaglutamyl-folate(THF)[m] = ADP[m] + H+[m] + hexaglutamyl-folate(THF)[m] + Pi[m]
Left to rightBalancedEC 6.3.2.17Human-GEM MAR08116
ATP[m] + glutamate[m] + hexaglutamyl-folate(THF)[m] = ADP[m] + H+[m] + heptaglutamyl-folate(THF)[m] + Pi[m]
Left to rightBalancedEC 6.3.2.17Human-GEM MAR08117
4 H2O[e] + pentaglutamyl-folate(DHF)[e] = dihydrofolate[e] + 4 glutamate[e]
Left to rightBalancedEC 3.4.19.9Human-GEM MAR08129
4 H2O[l] + pentaglutamyl-folate(DHF)[l] = dihydrofolate[l] + 4 glutamate[l]
Left to rightBalancedEC 3.4.19.9Human-GEM MAR08130