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Subsystem: Estrogen metabolism Remove
1–50 of 66 reactions in Estrogen metabolism
2 H+[c] + O2[c] + testosterone[c] = 19-hydroxytestosterone[c] + H2O[c]
Left to rightUnbalancedEC 1.14.14.1Human-GEM MAR02029
19-hydroxytestosterone[c] + 2 H+[c] + O2[c] = 19-oxo-testosterone[c] + 2 H2O[c]
Left to rightUnbalancedEC 1.14.14.1Human-GEM MAR02030
19-oxo-testosterone[c] + NADPH[c] + O2[c] = estradiol-17beta[c] + formate[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.14.1Human-GEM MAR02031
4-androstene-3,17-dione[c] + 2 H+[c] + O2[c] = 19-hydroxyandrostenedione[c] + H2O[c]
Left to rightUnbalancedEC 1.14.14.1Human-GEM MAR02032
19-hydroxyandrostenedione[c] + 2 H+[c] + O2[c] = 19-oxoandrostenedione[c] + 2 H2O[c]
Left to right
19-oxoandrostenedione[c] + NADPH[c] + O2[c] = estrone[c] + formate[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.14.1Human-GEM MAR02034
estrone[c] + H+[c] + NADPH[c] = estradiol-17beta[c] + NADP+[c]
ReversibleBalancedEC 1.1.1.62Human-GEM MAR02036
estrone[c] + PAPS[c] = estrone 3-sulfate[c] + H+[c] + PAP[c]
Left to rightBalancedEC 2.8.2.4Human-GEM MAR02037
estrone 3-sulfate[c] + H2O[c] = estrone[c] + H+[c] + sulfate[c]
Left to rightBalancedEC 3.1.6.1, 3.1.6.2Human-GEM MAR02038
estradiol-17beta[c] + H+[c] + NADPH[c] + O2[c] = 2-hydroxyestradiol-17beta[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.14.1Human-GEM MAR02042
estradiol-17beta[r] + H+[r] + NADPH[r] + O2[r] = 2-hydroxyestradiol-17beta[r] + H2O[r] + NADP+[r]
Left to rightBalancedEC 1.14.14.1Human-GEM MAR02043
2-hydroxy-3-methoxy-17beta-estradiol[c] + H+[c] + SAH[c] = 2-hydroxyestradiol-17beta[c] + SAM[c]
ReversibleBalancedEC 2.1.1.6Human-GEM MAR02044
2-hydroxyestradiol-17beta[c] + SAM[c] = 2-methoxyestradiol-17beta[c] + H+[c] + SAH[c]
ReversibleBalancedEC 2.1.1.6Human-GEM MAR02045
estradiol-17beta[c] + H+[c] + NADPH[c] + O2[c] = 4-hydroxy-17beta-estradiol[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.14.55Human-GEM MAR02046
estradiol-17beta[r] + H+[r] + NADPH[r] + O2[r] = 4-hydroxy-17beta-estradiol[r] + H2O[r] + NADP+[r]
Left to rightBalancedEC 1.14.14.55Human-GEM MAR02047
4-hydroxy-17beta-estradiol[c] + SAM[c] = 4-methoxy-17beta-estradiol[c] + H+[c] + SAH[c]
ReversibleBalancedEC 2.1.1.6Human-GEM MAR02048
estrone[c] + H+[c] + NADPH[c] + O2[c] = 4-hydroxyestrone[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.14.55Human-GEM MAR02049
estrone[l] + H+[l] + NADPH[l] + O2[l] = 4-hydroxyestrone[l] + H2O[l] + NADP+[l]
Left to rightBalancedEC 1.14.14.55Human-GEM MAR02050
estrone[r] + H+[r] + NADPH[r] + O2[r] = 4-hydroxyestrone[r] + H2O[r] + NADP+[r]
Left to rightBalancedEC 1.14.14.55Human-GEM MAR02051
4-hydroxyestrone[c] + SAM[c] = 4-methoxyestrone[c] + H+[c] + SAH[c]
ReversibleBalancedEC 2.1.1.6Human-GEM MAR02052
estrone[c] + H+[c] + NADPH[c] + O2[c] = 16alpha-hydroxyestrone[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.14.1Human-GEM MAR02053
estrone[r] + H+[r] + NADPH[r] + O2[r] = 16alpha-hydroxyestrone[r] + H2O[r] + NADP+[r]
Left to rightBalancedEC 1.14.14.1Human-GEM MAR02054
estrone[c] + H+[c] + NADPH[c] + O2[c] = 2-hydroxyestrone[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.14.55Human-GEM MAR02055
estrone[l] + H+[l] + NADPH[l] + O2[l] = 2-hydroxyestrone[l] + H2O[l] + NADP+[l]
Left to rightBalancedEC 1.14.14.55Human-GEM MAR02056
estrone[r] + H+[r] + NADPH[r] + O2[r] = 2-hydroxyestrone[r] + H2O[r] + NADP+[r]
Left to rightBalancedEC 1.14.14.55Human-GEM MAR02057
2-hydroxyestrone[c] + SAM[c] = 2-methoxyestrone[c] + H+[c] + SAH[c]
ReversibleBalancedEC 2.1.1.6Human-GEM MAR02058
2-hydroxyestrone[r] + SAM[r] = 2-methoxyestrone[r] + H+[r] + SAH[r]
ReversibleBalancedEC 2.1.1.6Human-GEM MAR02059
2-hydroxy-3-methoxyestrone[c] + H+[c] + SAH[c] = 2-hydroxyestrone[c] + SAM[c]
ReversibleBalancedEC 2.1.1.6Human-GEM MAR02060
2-hydroxyestrone[c] + H+[c] + H2O2[c] = estrone-2,3-semiquinone[c] + 2 H2O[c]
ReversibleUnbalancedEC 1.11.1.7, 1.11.1.8, 1.11.2.2Human-GEM MAR02061
2-hydroxyestrone[l] + H+[l] + H2O2[l] = estrone-2,3-semiquinone[l] + 2 H2O[l]
ReversibleUnbalancedEC 1.11.1.7, 1.11.1.8, 1.11.2.2Human-GEM MAR02062
2-hydroxyestrone[r] + H+[r] + H2O2[r] = estrone-2,3-semiquinone[r] + 2 H2O[r]
ReversibleUnbalancedEC 1.11.1.7, 1.11.1.8, 1.11.2.2Human-GEM MAR02063
estrone-2,3-semiquinone[c] + O2[c] = estrone-2,3-quinone[c] + H+[c] + O2-[c]
Left to rightBalancedHuman-GEM MAR02064
2-hydroxyestrone-1-S-glutathione[c] = estrone-2,3-quinone[c] + GSH[c]
ReversibleBalancedEC 2.5.1.18Human-GEM MAR02068
2-hydroxyestrone-1-S-glutathione[m] = estrone-2,3-quinone[m] + GSH[m]
ReversibleBalancedEC 2.5.1.18Human-GEM MAR02069
2-hydroxyestrone-1-S-glutathione[r] = estrone-2,3-quinone[r] + GSH[r]
ReversibleBalancedEC 2.5.1.18Human-GEM MAR02070
2-hydroxyestrone-1-S-glutathione[x] = estrone-2,3-quinone[x] + GSH[x]
ReversibleBalancedEC 2.5.1.18Human-GEM MAR02071
2-hydroxyestrone-4-S-glutathione[c] = estrone-2,3-quinone[c] + GSH[c]
ReversibleBalancedEC 2.5.1.18Human-GEM MAR02072
2-hydroxyestrone-4-S-glutathione[m] = estrone-2,3-quinone[m] + GSH[m]
ReversibleBalancedEC 2.5.1.18Human-GEM MAR02073
2-hydroxyestrone-4-S-glutathione[r] = estrone-2,3-quinone[r] + GSH[r]
ReversibleBalancedEC 2.5.1.18Human-GEM MAR02074
2-hydroxyestrone-4-S-glutathione[x] = estrone-2,3-quinone[x] + GSH[x]
ReversibleBalancedEC 2.5.1.18Human-GEM MAR02075
4-hydroxyestrone[c] + H+[c] + H2O2[c] = estrone-3,4-semiquinone[c] + 2 H2O[c]
ReversibleUnbalancedEC 1.11.1.7, 1.11.1.8, 1.11.2.2Human-GEM MAR02076
4-hydroxyestrone[l] + H+[l] + H2O2[l] = estrone-3,4-semiquinone[l] + 2 H2O[l]
ReversibleUnbalancedEC 1.11.1.7, 1.11.1.8, 1.11.2.2Human-GEM MAR02077
4-hydroxyestrone[r] + H+[r] + H2O2[r] = estrone-3,4-semiquinone[r] + 2 H2O[r]
ReversibleUnbalancedEC 1.11.1.7, 1.11.1.8, 1.11.2.2Human-GEM MAR02078
estrone-3,4-semiquinone[c] + O2[c] = estrone-3,4-quinone[c] + H+[c] + O2-[c]
Left to rightBalancedHuman-GEM MAR02079
4-hydroxyestrone-2-S-glutathione[c] = estrone-3,4-quinone[c] + GSH[c]
ReversibleBalancedEC 2.5.1.18Human-GEM MAR02083
4-hydroxyestrone-2-S-glutathione[m] = estrone-3,4-quinone[m] + GSH[m]
ReversibleBalancedEC 2.5.1.18Human-GEM MAR02084
4-hydroxyestrone-2-S-glutathione[r] = estrone-3,4-quinone[r] + GSH[r]
ReversibleBalancedEC 2.5.1.18Human-GEM MAR02085
4-hydroxyestrone-2-S-glutathione[x] = estrone-3,4-quinone[x] + GSH[x]
ReversibleBalancedEC 2.5.1.18Human-GEM MAR02086
17beta-estradiol-3,4-semiquinone[c] + 2 H2O[c] = 4-hydroxy-17beta-estradiol[c] + H2O2[c]
ReversibleBalancedEC 1.11.1.7, 1.11.1.8, 1.11.2.2Human-GEM MAR02088
17beta-estradiol-3,4-semiquinone[l] + 2 H2O[l] = 4-hydroxy-17beta-estradiol[l] + H2O2[l]
ReversibleBalancedEC 1.11.1.7, 1.11.1.8, 1.11.2.2Human-GEM MAR02089