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4,401–4,450 of 12,877 reactions from Human-GEM
deoxycytidine[c] + H2O[c] = deoxyuridine[c] + NH3[c]
Left to rightBalancedEC 3.5.4.5Pyrimidine metabolismHuman-GEM MAR04514
dodecanedioic acid[x] = dodecanedioic acid[c]
ReversibleBalancedTransportFatty acid oxidationHuman-GEM MAR04515
dCDP[c] + H2O[c] = dCMP[c] + H+[c] + Pi[c]
Left to rightBalancedEC 3.6.1.12Nucleotide metabolismHuman-GEM MAR04516
guanine[c] + H2O[c] = NH3[c] + xanthine[c]
Left to rightBalancedEC 3.5.4.3Purine metabolismHuman-GEM MAR04518
H2O[c] + hypoxanthine[c] + NAD+[c] = H+[c] + NADH[c] + xanthine[c]
Left to rightBalancedEC 1.17.1.4Purine metabolismHuman-GEM MAR04519
H2O[c] + hypoxanthine[c] + O2[c] = H2O2[c] + xanthine[c]
Left to rightBalancedEC 1.17.3.2Purine metabolismHuman-GEM MAR04520
glucose-6-phosphate[r] + H2O[r] = glucose[r] + Pi[r]
Left to rightBalancedEC 3.1.3.9Glycolysis / GluconeogenesisHuman-GEM MAR04521
(S)-3-hydroxydodecanoyl-CoA[c] + L-carnitine[c] = CoA[c] + 3-Hydroxydodecanoylcarnitine[c]
ReversibleBalancedEC 2.3.1.21Fatty acid oxidationHuman-GEM MAR04522
dihydrobiopterin[c] + H+[c] + NADPH[c] = NADP+[c] + tetrahydrobiopterin[c]
ReversibleBalancedEC 1.5.1.34Biopterin metabolismHuman-GEM MAR04523
ATP[c] + N-acetylglucosamine[c] = ADP[c] + H+[c] + N-acetylglucosamine-6-phosphate[c]
Left to rightBalancedEC 2.7.1.59Amino sugar and nucleotide sugar metabolismHuman-GEM MAR04524
H2O[r] + UDP-N-acetylglucosamine[r] = H+[r] + N-acetyl-D-mannosamine[r] + UDP[r]
Left to rightBalancedEC 5.1.3.14Amino sugar and nucleotide sugar metabolismHuman-GEM MAR04525
H2O[c] + UDP-N-acetylglucosamine[c] = H+[c] + N-acetyl-D-mannosamine[c] + UDP[c]
Left to rightBalancedEC 5.1.3.14Amino sugar and nucleotide sugar metabolismHuman-GEM MAR04526
N-acetyl-D-mannosamine[c] = N-acetylglucosamine[c]
ReversibleBalancedEC 5.1.3.8Amino sugar and nucleotide sugar metabolismHuman-GEM MAR04527
ATP[c] + N-acetyl-D-mannosamine[c] = ADP[c] + H+[c] + N-acetylmannosamine-6-phosphate[c]
Left to rightBalancedEC 2.7.1.60Amino sugar and nucleotide sugar metabolismHuman-GEM MAR04528
H2O[c] + N-acetylmannosamine-6-phosphate[c] + PEP[c] = N-acetylneuraminate-9-phosphate[c] + Pi[c]
Left to rightBalancedEC 2.5.1.56, 2.5.1.57Amino sugar and nucleotide sugar metabolismHuman-GEM MAR04529
H2O[c] + N-acetylneuraminate-9-phosphate[c] = N-acetylneuraminate[c] + Pi[c]
Left to rightBalancedEC 3.1.3.29Amino sugar and nucleotide sugar metabolismHuman-GEM MAR04530
H+[c] + N-acetylneuraminate[c] + NADH[c] + O2[c] = H2O[c] + NAD+[c] + neungc[c]
Left to rightBalancedEC 1.14.18.2Amino sugar and nucleotide sugar metabolismHuman-GEM MAR04531
CTP[c] + neungc[c] = CMP-neuNGc[c] + PPi[c]
Left to rightBalancedEC 2.7.7.43Amino sugar and nucleotide sugar metabolismHuman-GEM MAR04532
CMP-neuNGc[c] + H2O[c] + NAD+[c] = CMP-N-acetylneuraminate[c] + H+[c] + NADH[c] + O2[c]
Left to rightBalancedEC 1.14.18.2Amino sugar and nucleotide sugar metabolismHuman-GEM MAR04533
CMP-neuNGc[c] + H2O[c] + NADP+[c] = CMP-N-acetylneuraminate[c] + H+[c] + NADPH[c] + O2[c]
Left to rightBalancedEC 1.14.18.2Amino sugar and nucleotide sugar metabolismHuman-GEM MAR04534
CMP-N-acetylneuraminate[c] = CMP-N-acetylneuraminate[n]
ReversibleBalancedTransportTransport reactionsHuman-GEM MAR04535
CTP[n] + N-acetylneuraminate[n] = CMP-N-acetylneuraminate[n] + PPi[n]
Left to rightBalancedEC 2.7.7.43Amino sugar and nucleotide sugar metabolismHuman-GEM MAR04536
O2[c] + tetrahydrobiopterin[c] + tryptophan[c] = 4alpha-hydroxytetrahydrobiopterin[c] + 5-hydroxy-L-tryptophan[c]
Left to rightBalancedEC 1.14.16.4Serotonin and melatonin biosynthesisHuman-GEM MAR04537
4alpha-hydroxytetrahydrobiopterin[c] = 4alpha-hydroxytetrahydrobiopterin[n]
ReversibleBalancedTransportTransport reactionsHuman-GEM MAR04538
4alpha-hydroxytetrahydrobiopterin[c] = H2O[c] + O2-4a-cyclic-tetrahydrobiopterin[c]
ReversibleBalancedEC 4.2.1.96Biopterin metabolismHuman-GEM MAR04539
4alpha-hydroxytetrahydrobiopterin[n] = H2O[n] + O2-4a-cyclic-tetrahydrobiopterin[n]
ReversibleBalancedEC 4.2.1.96Biopterin metabolismHuman-GEM MAR04540
O2-4a-cyclic-tetrahydrobiopterin[c] = quinonoid dihydrobiopterin[c]
ReversibleBalancedEC 4.2.1.96Biopterin metabolismHuman-GEM MAR04541
O2-4a-cyclic-tetrahydrobiopterin[n] = quinonoid dihydrobiopterin[n]
ReversibleBalancedEC 4.2.1.96Biopterin metabolismHuman-GEM MAR04542
4alpha-hydroxytetrahydrobiopterin[c] = H2O[c] + quinonoid dihydrobiopterin[c]
ReversibleBalancedEC 4.2.1.96Biopterin metabolismHuman-GEM MAR04543
4alpha-hydroxytetrahydrobiopterin[n] = H2O[n] + quinonoid dihydrobiopterin[n]
ReversibleBalancedEC 4.2.1.96Biopterin metabolismHuman-GEM MAR04544
5-hydroxy-L-tryptophan[c] + H+[c] = CO2[c] + serotonin[c]
Left to rightBalancedEC 4.1.1.28Serotonin and melatonin biosynthesisHuman-GEM MAR04545
acetyl-CoA[c] + serotonin[c] = CoA[c] + H+[c] + N-acetyl-serotonin[c]
Left to rightBalancedEC 2.3.1.87Serotonin and melatonin biosynthesisHuman-GEM MAR04546
N-acetyl-serotonin[c] + SAM[c] = H+[c] + melatonin[c] + SAH[c]
Left to rightBalancedEC 2.1.1.4Serotonin and melatonin biosynthesisHuman-GEM MAR04547
6-hydroxymelatonin[c] + H+[c] = hydroxide[c] + melatonin[c]
ReversibleUnbalancedEC 1.14.14.1Serotonin and melatonin biosynthesisHuman-GEM MAR04548
6-hydroxymelatonin-sulfate[c] + H+[c] = 6-hydroxymelatonin[c] + sulfite[c]
ReversibleUnbalancedEC 2.8.2.-Serotonin and melatonin biosynthesisHuman-GEM MAR04549
melatonin[c] + O2[c] = formyl-N-acetyl-5-methoxykynurenamine[c]
Left to rightBalancedEC 1.13.11.52Serotonin and melatonin biosynthesisHuman-GEM MAR04550
2 formyl-N-acetyl-5-methoxykynurenamine[c] + H2O2[c] = CO2[c] + formate[c] + H+[c] + 2 N-acetyl-5-methoxykynuramine[c]
Left to rightBalancedSerotonin and melatonin biosynthesisHuman-GEM MAR04551
hydroxide[c] + melatonin[c] = melatonin radical[c]
ReversibleUnbalancedSerotonin and melatonin biosynthesisHuman-GEM MAR04552
cyclic-3-hydroxymelatonin[c] + H2O[c] = hydroxide[c] + melatonin radical[c]
ReversibleUnbalancedSerotonin and melatonin biosynthesisHuman-GEM MAR04553
6-hydroxy-1,2,3,4-tetrahydro-beta-carboline[c] + H2O[c] = formaldehyde[c] + serotonin[c]
ReversibleBalancedSerotonin and melatonin biosynthesisHuman-GEM MAR04554
SAM[c] + serotonin[c] = H+[c] + N-methylserotonin[c] + SAH[c]
Left to rightBalancedEC 2.1.1.49Serotonin and melatonin biosynthesisHuman-GEM MAR04555
N-methylserotonin[c] + SAM[c] = bufotenine[c] + 2 H+[c] + SAH[c]
ReversibleBalancedEC 2.1.1.49Serotonin and melatonin biosynthesisHuman-GEM MAR04556
O2[c] + serotonin[c] = formyl-5-hydroxykynurenamine[c]
Left to rightBalancedEC 1.13.11.52Serotonin and melatonin biosynthesisHuman-GEM MAR04557
H2O[c] + O2[c] + serotonin[c] = 5-hydroxyindoleacetaldehyde[c] + H+[c] + H2O2[c] + NH3[c]
Left to rightBalancedEC 1.4.3.4Serotonin and melatonin biosynthesisHuman-GEM MAR04558
5-hydroxyindoleacetaldehyde[c] + H2O[c] + NAD+[c] = 5-hydroxyindoleacetate[c] + 2 H+[c] + NADH[c]
Left to rightBalancedEC 1.2.1.3Serotonin and melatonin biosynthesisHuman-GEM MAR04559
5-hydroxyindoleacetaldehyde[c] + H2O[c] + O2[c] = 5-hydroxyindoleacetate[c] + H+[c] + H2O2[c]
Left to rightBalancedEC 1.2.3.1Serotonin and melatonin biosynthesisHuman-GEM MAR04560
5-hydroxyindoleacetaldehyde[c] + H+[c] + NADPH[c] = 5-hydroxytryptophol[c] + NADP+[c]
ReversibleBalancedEC 1.1.1.1Serotonin and melatonin biosynthesisHuman-GEM MAR04561
5-hydroxytryptophol[c] + SAM[c] = 5-methoxytryptophol[c] + H+[c] + SAH[c]
Left to rightBalancedEC 2.1.1.6Serotonin and melatonin biosynthesisHuman-GEM MAR04563
5-hydroxyindoleacetate[c] + SAM[c] = 5-methoxyindoleacetate[c] + H+[c] + SAH[c]
Left to rightBalancedEC 2.1.1.4Serotonin and melatonin biosynthesisHuman-GEM MAR04564
D-glyceraldehyde 3-phosphate[c] + sedoheptulose-7-phosphate[c] = erythrose-4-phosphate[c] + fructose-6-phosphate[c]
ReversibleBalancedEC 2.2.1.2Pentose phosphate pathwayHuman-GEM MAR04565