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Subsystem: Serotonin and melatonin biosynthesis Remove
20 reactions in Serotonin and melatonin biosynthesis
O2[c] + tetrahydrobiopterin[c] + tryptophan[c] = 4alpha-hydroxytetrahydrobiopterin[c] + 5-hydroxy-L-tryptophan[c]
Left to rightBalancedEC 1.14.16.4Human-GEM MAR04537
5-hydroxy-L-tryptophan[c] + H+[c] = CO2[c] + serotonin[c]
Left to rightBalancedEC 4.1.1.28Human-GEM MAR04545
acetyl-CoA[c] + serotonin[c] = CoA[c] + H+[c] + N-acetyl-serotonin[c]
Left to rightBalancedEC 2.3.1.87Human-GEM MAR04546
N-acetyl-serotonin[c] + SAM[c] = H+[c] + melatonin[c] + SAH[c]
Left to rightBalancedEC 2.1.1.4Human-GEM MAR04547
6-hydroxymelatonin[c] + H+[c] = hydroxide[c] + melatonin[c]
Reversible
6-hydroxymelatonin-sulfate[c] + H+[c] = 6-hydroxymelatonin[c] + sulfite[c]
ReversibleUnbalancedEC 2.8.2.-Human-GEM MAR04549
melatonin[c] + O2[c] = formyl-N-acetyl-5-methoxykynurenamine[c]
Left to rightBalancedEC 1.13.11.52Human-GEM MAR04550
2 formyl-N-acetyl-5-methoxykynurenamine[c] + H2O2[c] = CO2[c] + formate[c] + H+[c] + 2 N-acetyl-5-methoxykynuramine[c]
Left to rightBalancedHuman-GEM MAR04551
hydroxide[c] + melatonin[c] = melatonin radical[c]
ReversibleUnbalancedHuman-GEM MAR04552
cyclic-3-hydroxymelatonin[c] + H2O[c] = hydroxide[c] + melatonin radical[c]
ReversibleUnbalancedHuman-GEM MAR04553
6-hydroxy-1,2,3,4-tetrahydro-beta-carboline[c] + H2O[c] = formaldehyde[c] + serotonin[c]
ReversibleBalancedHuman-GEM MAR04554
SAM[c] + serotonin[c] = H+[c] + N-methylserotonin[c] + SAH[c]
Left to rightBalancedEC 2.1.1.49Human-GEM MAR04555
N-methylserotonin[c] + SAM[c] = bufotenine[c] + 2 H+[c] + SAH[c]
ReversibleBalancedEC 2.1.1.49Human-GEM MAR04556
O2[c] + serotonin[c] = formyl-5-hydroxykynurenamine[c]
Left to rightBalancedEC 1.13.11.52Human-GEM MAR04557
H2O[c] + O2[c] + serotonin[c] = 5-hydroxyindoleacetaldehyde[c] + H+[c] + H2O2[c] + NH3[c]
Left to rightBalancedEC 1.4.3.4Human-GEM MAR04558
5-hydroxyindoleacetaldehyde[c] + H2O[c] + NAD+[c] = 5-hydroxyindoleacetate[c] + 2 H+[c] + NADH[c]
Left to rightBalancedEC 1.2.1.3Human-GEM MAR04559
5-hydroxyindoleacetaldehyde[c] + H2O[c] + O2[c] = 5-hydroxyindoleacetate[c] + H+[c] + H2O2[c]
Left to rightBalancedEC 1.2.3.1Human-GEM MAR04560
5-hydroxyindoleacetaldehyde[c] + H+[c] + NADPH[c] = 5-hydroxytryptophol[c] + NADP+[c]
ReversibleBalancedEC 1.1.1.1Human-GEM MAR04561
5-hydroxytryptophol[c] + SAM[c] = 5-methoxytryptophol[c] + H+[c] + SAH[c]
Left to rightBalancedEC 2.1.1.6Human-GEM MAR04563
5-hydroxyindoleacetate[c] + SAM[c] = 5-methoxyindoleacetate[c] + H+[c] + SAH[c]
Left to rightBalancedEC 2.1.1.4Human-GEM MAR04564