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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Proteins
Interactions
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Chemistry

Reactions
Reach

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Organisms
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

3,601–3,650 of 18,558 reactions from Rhea

UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine + H2O = 2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + UMP + 2 H(+)
Direction not assertedBalancedRhea 25213
serotonin + acetyl-CoA = N-acetylserotonin + CoA + H(+)
Direction not assertedBalancedRhea 25217
L-cysteate + H(+) = taurine + CO2
Direction not assertedBalancedRhea 25221
L-arabinitol + NAD(+) = L-arabinose + NADH + H(+)
Direction not assertedBalancedRhea 25225
L-arabinitol + NADP(+) = L-arabinose + NADPH + H(+)
Direction not assertedBalancedRhea 25229
N-acetyl-alpha-neuraminate = N-acetyl-beta-neuraminate
Direction not assertedBalancedRhea 25233
CDP + ATP = CTP + ADP

→ Left to right

Balanced

Rhea 25237

(S)-2-ureidoglycine + H2O = (S)-ureidoglycolate + NH4(+)

Direction not assertedBalancedRhea 25241

(R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)

Left to rightBalancedRhea 25245

2 pyruvate + H(+) = (2S)-2-acetolactate + CO2

Direction not assertedBalancedRhea 25249

aldehydo-N-acetyl-D-mannosamine + ATP = aldehydo-N-acetyl-D-mannosamine 6-phosphate + ADP + H(+)

Left to rightBalancedRhea 25253

N-acetyl-D-glucosamine 6-phosphate = aldehydo-N-acetyl-D-mannosamine 6-phosphate

Direction not assertedBalancedRhea 25257

2-hydroxyglutarate + FAD + H(+) = FADH2 + 2-oxoglutarate

Direction not assertedBalancedRhea 25261

2-phenylethylamine + O2 + H2O = 2-phenylacetaldehyde + H2O2 + NH4(+)

Left to rightBalancedRhea 25265

(R)-noradrenaline + S-adenosyl-L-methionine = (R)-adrenaline + S-adenosyl-L-homocysteine + H(+)

Left to rightBalancedRhea 25269

UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate + D-lysine + ATP = N(6)-(UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl)-D-lysine + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 25273

3',5'-cyclic AMP + H2O = AMP + H(+)

Left to rightBalancedRhea 25277

squalene + reduced [NADPH--hemoprotein reductase] + O2 = (S)-2,3-epoxysqualene + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 25282

lanosterol + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)

Left to rightBalance undeterminableRhea 25286

ethanol + NAD(+) = acetaldehyde + NADH + H(+)

Left to rightBalancedRhea 25290

acetaldehyde + NAD(+) + H2O = acetate + NADH + 2 H(+)

Left to rightBalancedRhea 25294

acetaldehyde + NADP(+) + H2O = acetate + NADPH + 2 H(+)

Direction not assertedBalancedRhea 25298

7,8-dihydroneopterin 3'-triphosphate + H2O = 7,8-dihydroneopterin 3'-phosphate + diphosphate + H(+)

Direction not assertedBalancedRhea 25302

7,8-dihydroneopterin + phosphate = 7,8-dihydroneopterin 3'-phosphate + H2O

Direction not assertedBalancedRhea 25306

glycolate + O2 = glyoxylate + H2O2

Left to rightBalancedRhea 25311

N-acetyl-(2S,6S)-2,6-diaminopimelate + 2-oxoglutarate = L-2-acetamido-6-oxoheptanedioate + L-glutamate

Direction not assertedBalancedRhea 25315

N-methylethanolamine phosphate + S-adenosyl-L-methionine = N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 25321

N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine = phosphocholine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 25325

(R)-carnitine + NAD(+) = 3-dehydrocarnitine + NADH + H(+)

Direction not assertedBalancedRhea 25330

L-cysteinyl-tRNA(Cys) + H2O = tRNA(Cys) + L-cysteine + H(+)

Direction not assertedBalancedRhea 25334

urea + H(+) = isocyanate + NH4(+)

Direction not assertedBalancedRhea 25338

urea + H2O = carbamate + NH4(+)

Direction not assertedBalancedRhea 25342

D-tyrosyl-tRNA(Tyr) + H2O = D-tyrosine + tRNA(Tyr)

Direction not assertedBalancedRhea 25347

L-cysteinyl-tRNA(Pro) + H2O = tRNA(Pro) + L-cysteine + H(+)

Direction not assertedBalancedRhea 25351

2-hydroxyphytanoyl-CoA = 2,6,10,14-tetramethylpentadecanal + formyl-CoA

Left to rightBalancedRhea 25355

(3Z)-phycoerythrobilin + 2 oxidized 2[4Fe-4S]-[ferredoxin] = biliverdin IXalpha + 2 reduced 2[4Fe-4S]-[ferredoxin] + 4 H(+)

Direction not assertedBalance undeterminableRhea 25359

3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NAD(+) = momilactone A + NADH + H(+)

Direction not assertedBalancedRhea 25363

3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NADP(+) = momilactone A + NADPH + H(+)

Direction not assertedBalancedRhea 25367

(2S)-2-amino-4-deoxychorismate + FMN = 3-(1-carboxyvinyloxy)anthranilate + FMNH2

Direction not assertedBalancedRhea 25371

a 2-hydroxy-3-methyl fatty acyl-CoA = a 2-methyl-branched fatty aldehyde + formyl-CoA

Left to rightBalance undeterminableRhea 25375

2-hydroxy-3-methylhexadecanoyl-CoA = 2-methylpentadecanal + formyl-CoA

Left to rightBalancedRhea 25379

(3Z)-6-oxohex-3-enoyl-CoA + NADP(+) + H2O = cis-3,4-dehydroadipyl-CoA + NADPH + 2 H(+)

Direction not assertedBalancedRhea 25391

(9Z,12Z)-octadecadienoate + O2 = (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate

Direction not assertedBalancedRhea 25395

(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate = (7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate

Direction not assertedBalancedRhea 25399

(S)-2-ethyl-2-hydroxy-3-oxobutanoate = (R)-3-hydroxy-3-methyl-2-oxopentanoate

Direction not assertedBalancedRhea 25404

ADP-alpha-D-glucose + D-glucose = alpha,alpha-trehalose + ADP + H(+)

Direction not assertedBalancedRhea 25408

octadecanoyl-CoA + AH2 + O2 = (9Z)-octadecenoyl-CoA + A + 2 H2O

Direction not assertedBalancedRhea 25416

3-hydroxybenzoyl-CoA + AH2 + 2 ATP + 2 H2O = 3-hydroxycyclohexa-1,5-diene-1-carbonyl-CoA + A + 2 ADP + 2 phosphate + 2 H(+)

Direction not assertedBalancedRhea 25420

GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate

Right to leftBalancedRhea 25424

N-acetyl-D-hexosamine + ATP = N-acetyl-alpha-D-hexosamine 1-phosphate + ADP + H(+)

Direction not assertedBalancedRhea 25428

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