Skip to content

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

3,401–3,450 of 18,558 reactions from Rhea

D-xylulose 5-phosphate + formaldehyde = dihydroxyacetone + D-glyceraldehyde 3-phosphate
Direction not assertedBalancedRhea 24264
2,6-dioxo-6-phenylhexanoate + NADP(+) = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + NADPH + H(+)
Direction not assertedBalancedRhea 24268
Mg-protoporphyrin IX 13-monomethyl ester + NADPH + O2 + H(+) = Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADP(+) + H2O
Direction not assertedBalancedRhea 24272
acetate + diphosphate = acetyl phosphate + phosphate
Direction not assertedBalancedRhea 24276
L-aspartate 4-semialdehyde + phosphate + NADP(+) = 4-phospho-L-aspartate + NADPH + H(+)
Direction not assertedBalancedRhea 24284
5-formimidoyltetrahydrofolate + glycine = N-formimidoylglycine + (6S)-5,6,7,8-tetrahydrofolate
Direction not assertedBalancedRhea 24288

L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+)

Direction not assertedBalancedRhea 24292

(S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate + H(+)

Direction not assertedBalancedRhea 24296

2 cob(I)yrinate a,c diamide + FMN + 3 H(+) = 2 cob(II)yrinate a,c diamide + FMNH2

Direction not assertedBalancedRhea 24300

N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein] + CO2

Direction not assertedBalance undeterminableRhea 24304

25-hydroxycholesterol + reduced [NADPH--hemoprotein reductase] + O2 = 7alpha,25-dihydroxycholesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 24308

L-lysyl-[cytochrome c] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl-[cytochrome c] + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalance undeterminableRhea 24312

(2E,6E,10E)-geranylgeranyl diphosphate = (+)-copalyl diphosphate

Direction not assertedBalancedRhea 24316

an L-polyhomomethionine + reduced [NADPH--hemoprotein reductase] + O2 = an L-N-hydroxypolyhomomethionine + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)

Direction not assertedBalance undeterminableRhea 24320

6-oxocineole + NADPH + O2 + H(+) = 1,6,6-trimethyl-2,7-dioxabicyclo[3.2.2]nonan-3-one + NADP(+) + H2O

Direction not assertedBalancedRhea 24324

7,8-dihydrofolate + formate + ATP = 10-formyldihydrofolate + ADP + phosphate

Direction not assertedBalancedRhea 24328

3alpha-hydroxy-3,5-dihydromonacolin L carboxylate = monacolin L carboxylate + H2O

Direction not assertedBalancedRhea 24332

a carboxylate + ATP + CoA = an acyl-CoA + AMP + diphosphate

Direction not assertedBalance undeterminableRhea 24336

(R,R)-butane-2,3-diol + NAD(+) = (R)-acetoin + NADH + H(+)

Direction not assertedBalancedRhea 24340

ethyl (R)-3-hydroxyhexanoate + NADP(+) = ethyl 3-oxohexanoate + NADPH + H(+)

Direction not assertedBalancedRhea 24352

a 1-acyl-sn-glycero-3-phosphocholine = a 2-acyl-sn-glycero-3-phosphocholine

Direction not assertedBalance undeterminableRhea 24356

siroheme + 2 H(+) = sirohydrochlorin + Fe(2+)

Direction not assertedBalancedRhea 24360

N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-(2-hydroxyisobutanoyl)-ADP-D-ribose + nicotinamide + L-lysyl-[protein]

Direction not assertedBalance undeterminableRhea 24364

L-ornithine = L-proline + NH4(+)

Direction not assertedBalancedRhea 24368

N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + H2O = N(4)-[6-phospho-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + N-acetyl-D-glucosamine + H(+)

Direction not assertedBalance undeterminableRhea 24372

apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] + biotin + ATP = holo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] + AMP + diphosphate + H(+)

Left to rightBalance undeterminableRhea 24376

L-methionyl-tRNA(fMet) + (6R)-10-formyltetrahydrofolate = N-formyl-L-methionyl-tRNA(fMet) + (6S)-5,6,7,8-tetrahydrofolate + H(+)

Left to rightBalancedRhea 24380

deamido-NAD(+) + L-glutamine + ATP + H2O = L-glutamate + AMP + diphosphate + NAD(+) + H(+)

Left to rightBalancedRhea 24384

uridine + phosphate = alpha-D-ribose 1-phosphate + uracil

Left to rightBalancedRhea 24388

dTDP-L-dihydrostreptose + streptidine 6-phosphate = O-(1->4)-alpha-L-dihydrostreptosyl-streptidine 6-phosphate + dTDP + H(+)

Direction not assertedBalancedRhea 24392

scytalone = 1,3,8-trihydroxynaphthalene + H2O

Direction not assertedBalancedRhea 24396

UMP + ATP = UDP + ADP

Direction not assertedBalancedRhea 24400

(3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA

Direction not assertedBalancedRhea 24404

adenosine + H2O + H(+) = inosine + NH4(+)

Left to rightBalancedRhea 24408

4-(hydroxymethyl)benzenesulfonate + NAD(+) = 4-formylbenzenesulfonate + NADH + H(+)

Direction not assertedBalancedRhea 24412

2,4'-dihydroxyacetophenone + O2 = 4-hydroxybenzoate + formate + 2 H(+)

Direction not assertedBalancedRhea 24416

N-terminal N-formyl-L-methionyl-[peptide] + H2O = N-terminal L-methionyl-[peptide] + formate

Direction not assertedBalance undeterminableRhea 24420

L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate

Left to rightBalancedRhea 24424

oxaloacetate + H2O = oxalate + acetate + H(+)

Direction not assertedBalancedRhea 24432

methanophenazine + H2 = dihydromethanophenazine

Direction not assertedBalancedRhea 24436

phosphate(out) + ATP + H2O = ADP + 2 phosphate(in) + H(+)

Direction not assertedBalancedTransportRhea 24440

N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + GDP-beta-L-fucose = N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc(1->3)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + GDP + H(+)

Direction not assertedBalance undeterminableRhea 24444

enterobactin + UDP-alpha-D-glucose = monoglucosyl-enterobactin + UDP

Direction not assertedBalancedRhea 24448

L-glutamyl-[protein] + S-adenosyl-L-methionine = [protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine

Direction not assertedBalance undeterminableRhea 24452

alpha-ribazole 5'-phosphate + H2O = alpha-ribazole + phosphate

Direction not assertedBalancedRhea 24456

malonyl-[ACP] + H(+) = acetyl-[ACP] + CO2

Direction not assertedBalance undeterminableRhea 24460

2-dehydro-3-deoxy-6-phospho-D-galactonate = D-glyceraldehyde 3-phosphate + pyruvate

Direction not assertedBalancedRhea 24464

N,N-dimethylaniline + NADPH + O2 + H(+) = N,N-dimethylaniline N-oxide + NADP(+) + H2O

Left to rightBalancedRhea 24468

maleimide + H2O = maleamate + H(+)

Direction not assertedBalancedRhea 24476

a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside + H2O = a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose + an alcohol

Direction not assertedBalance undeterminableRhea 24480

Page 69 of 372