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3,351–3,400 of 12,877 reactions from Human-GEM
(11Z,14Z,17Z)-eicosatrienoyl-CoA[m] + 9 CoA[m] + 6 FAD[m] + 9 H2O[m] + 9 NAD+[m] = 10 acetyl-CoA[m] + 6 FADH2[m] + 9 H+[m] + 9 NADH[m]
Left to rightBalancedEC 4.2.1.17, 1.1.1.35, 1.1.1.211, 1.3.8.7, 1.3.8.8, 1.3.8.9, 2.3.1.16Beta oxidation of even-chain fatty acids (mitochondrial)Human-GEM MAR03431
13,16,19-docosatrienoyl-CoA[m] + 10 CoA[m] + 7 FAD[m] + 10 H2O[m] + 10 NAD+[m] = 11 acetyl-CoA[m] + 7 FADH2[m] + 10 H+[m] + 10 NADH[m]
Left to rightBalancedEC 4.2.1.17, 1.1.1.35, 1.1.1.211, 1.3.8.7, 1.3.8.8, 1.3.8.9, 2.3.1.16Beta oxidation of even-chain fatty acids (mitochondrial)Human-GEM MAR03432
10,13,16,19-docosatetraenoyl-CoA[m] + 10 CoA[m] + 6 FAD[m] + 10 H2O[m] + 10 NAD+[m] = 11 acetyl-CoA[m] + 6 FADH2[m] + 10 H+[m] + 10 NADH[m]
Left to rightBalancedEC 4.2.1.17, 1.1.1.35, 1.1.1.211, 1.3.8.7, 1.3.8.8, 1.3.8.9, 2.3.1.16Beta oxidation of even-chain fatty acids (mitochondrial)Human-GEM MAR03433
H+[r] + NADPH[r] + 4,4-Dimethylcholesta-8(9),14-Dien-3Beta-Ol[r] = 4,4-dimethyl-5alpha-cholesta-8-en-3-beta-ol[r] + NADP+[r]
ReversibleBalancedEC 1.3.1.70Cholesterol metabolismHuman-GEM MAR03434
NADPH[c] + O2[c] + 24,25,26,27-Tetranor-23-Oxo-Hydroxyvitamin D3[c] = calcitroic acid[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 2.3.1.16Vitamin D metabolismHuman-GEM MAR03435
NADPH[m] + O2[m] + 24,25,26,27-Tetranor-23-Oxo-Hydroxyvitamin D3[m] = calcitroic acid[m] + H2O[m] + NADP+[m]
Left to rightBalancedEC 1.14.15.16Vitamin D metabolismHuman-GEM MAR03436
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA[c] + 3 H+[c] + NADPH[c] = (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA[c] + NADP+[c]
ReversibleUnbalancedFatty acid oxidationHuman-GEM MAR03437
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA[r] + 3 H+[r] + NADPH[r] = (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA[r] + NADP+[r]
ReversibleUnbalancedEC 2.3.1.199Fatty acid oxidationHuman-GEM MAR03438
(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA[c] + malonyl-CoA[c] = 3-oxo-all-cis-6,9,12,15,18-tetracosapentaenoyl-CoA[c] + CO2[c] + CoA[c] + H+[c]
Left to rightUnbalancedEC 2.3.1.199Fatty acid oxidationHuman-GEM MAR03439
(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA[r] + malonyl-CoA[r] = 3-oxo-all-cis-6,9,12,15,18-tetracosapentaenoyl-CoA[r] + CO2[r] + CoA[r] + H+[r]
Left to rightUnbalancedEC 1.1.1.50Fatty acid oxidationHuman-GEM MAR03440
2-trans-9,12,15,18-all-cis-tetracosapentaenoyl-CoA[r] + H+[r] + NADPH[r] = (9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA[r] + NADP+[r]
ReversibleBalancedEC 2.3.1.199Fatty acid oxidationHuman-GEM MAR03442
arachidonyl-CoA[r] + H+[r] + malonyl-CoA[r] = 3-oxo-docosa-7,10,13,16-all-cis-tetraenoyl-CoA[r] + CO2[r] + CoA[r]
Left to rightBalancedEC 1.1.1.145Fatty acid oxidationHuman-GEM MAR03443
arachidonyl-CoA[m] + FAD[m] = 2-trans-cis,cis,cis,cis-4,8,11,14-eicosapentaenoyl-CoA[m] + FADH2[m]
Left to rightBalancedEC 1.3.8.7, 1.3.8.8, 1.3.8.9, 1.3.99.-Omega-6 fatty acid metabolismHuman-GEM MAR03444
2-trans-cis,cis,cis,cis-4,8,11,14-eicosapentaenoyl-CoA[m] = trans-3-cis-5,8,11,14-eicosapentaenoyl-CoA[m]
Left to rightBalancedEC 5.3.3.8Omega-6 fatty acid metabolismHuman-GEM MAR03445
2-trans-cis,cis,cis,cis-4,8,11,14-eicosapentaenoyl-CoA[m] + H+[m] + NADPH[m] = NADP+[m] + trans-3-cis-8,11,14-eicosatetraenoyl-CoA[m]
Left to rightBalancedEC 1.3.1.34Omega-6 fatty acid metabolismHuman-GEM MAR03446
trans-3-cis-8,11,14-eicosatetraenoyl-CoA[m] = trans-2-cis,cis,cis-8,11,14-eicosatetraenoyl-CoA[m]
Left to rightBalancedEC 5.3.3.8, 5.3.3.-Omega-6 fatty acid metabolismHuman-GEM MAR03447
dihomo-gamma-linolenoyl-CoA[m] + FAD[m] = FADH2[m] + trans-2-cis,cis,cis-8,11,14-eicosatetraenoyl-CoA[m]
Left to rightBalancedEC 1.3.8.7, 1.3.8.8, 1.3.8.9, 1.3.99.-Omega-6 fatty acid metabolismHuman-GEM MAR03448
H2O[m] + trans-2-cis,cis,cis-8,11,14-eicosatetraenoyl-CoA[m] = 3(S)-hydroxy-dihomo-gamma-linolenoyl-CoA[m]
Left to rightBalancedEC 4.2.1.17Omega-6 fatty acid metabolismHuman-GEM MAR03449
3(S)-hydroxy-dihomo-gamma-linolenoyl-CoA[m] + NAD+[m] = 3-oxo-dihomo-gamma-linolenoyl-CoA[m] + H+[m] + NADH[m]
Left to rightBalancedEC 1.1.1.35, 1.1.1.211Omega-6 fatty acid metabolismHuman-GEM MAR03450
3-oxo-docosa-7,10,13,16-all-cis-tetraenoyl-CoA[r] + H+[r] + NADPH[r] = 3(S)-hydroxy-docosa-7,10,13,16-all-cis-tetraenoyl-CoA[r] + NADP+[r]
ReversibleBalancedEC 2.3.1.199Fatty acid oxidationHuman-GEM MAR03451
FAD[m] + gamma-linolenoyl-CoA[m] = (2E,6Z,9Z,12Z)-octadecatetraenoyl-CoA[m] + FADH2[m]
Left to rightBalancedEC 1.3.8.7, 1.3.8.8, 1.3.8.9, 1.3.99.-Omega-6 fatty acid metabolismHuman-GEM MAR03452
(2E,6Z,9Z,12Z)-octadecatetraenoyl-CoA[m] + H2O[m] = 3(S)-hydroxy-(6Z,9Z,12Z)-octadecatrienoyl-CoA[m]
Left to rightBalancedEC 4.2.1.17Omega-6 fatty acid metabolismHuman-GEM MAR03453
3(S)-hydroxy-(6Z,9Z,12Z)-octadecatrienoyl-CoA[m] + NAD+[m] = 3-oxo-(6Z,9Z,12Z)-octadecatrienoyl-CoA[m] + H+[m] + NADH[m]
ReversibleBalancedEC 1.1.1.35, 1.1.1.211Omega-6 fatty acid metabolismHuman-GEM MAR03454
(4Z,7Z,10Z)-hexadecatrienoyl-CoA[m] + acetyl-CoA[m] = 3-oxo-(6Z,9Z,12Z)-octadecatrienoyl-CoA[m] + CoA[m]
ReversibleBalancedEC 2.3.1.16, 1.1.1.211Omega-6 fatty acid metabolismHuman-GEM MAR03455
(4Z,7Z,10Z)-hexadecatrienoyl-CoA[m] + O2[m] = (2E,4Z,7Z,10Z)-hexadecatetraenoyl-CoA[m] + H2O2[m]
Left to rightBalancedEC 1.3.8.7, 1.3.8.8, 1.3.8.9, 1.3.99.-Omega-6 fatty acid metabolismHuman-GEM MAR03456
(2E,4Z,7Z,10Z)-hexadecatetraenoyl-CoA[m] + H+[m] + NADPH[m] = (3Z,7Z,10Z)-hexadecatrienoyl-CoA[m] + NADP+[m]
ReversibleBalancedEC 1.3.1.34Omega-6 fatty acid metabolismHuman-GEM MAR03457
(3Z,7Z,10Z)-hexadecatrienoyl-CoA[m] = trans,cis,cis-2,7,10-hexadecatrienoyl-CoA[m]
Left to rightBalancedEC 5.3.3.8Omega-6 fatty acid metabolismHuman-GEM MAR03458
arachidonyl-CoA[x] + FAD[x] = 2-trans-cis,cis,cis,cis-4,8,11,14-eicosapentaenoyl-CoA[x] + FADH2[x]
Left to rightBalancedEC 1.3.3.6Omega-6 fatty acid metabolismHuman-GEM MAR03459
2-trans-cis,cis,cis,cis-4,8,11,14-eicosapentaenoyl-CoA[x] = trans-3-cis-5,8,11,14-eicosapentaenoyl-CoA[x]
Left to rightBalancedEC 5.3.3.8Omega-6 fatty acid metabolismHuman-GEM MAR03460
2-trans-cis,cis,cis,cis-4,8,11,14-eicosapentaenoyl-CoA[x] + H+[x] + NADPH[x] = NADP+[x] + trans-3-cis-8,11,14-eicosatetraenoyl-CoA[x]
Left to rightBalancedEC 1.3.1.34Omega-6 fatty acid metabolismHuman-GEM MAR03461
trans-3-cis-8,11,14-eicosatetraenoyl-CoA[x] = trans-2-cis,cis,cis-8,11,14-eicosatetraenoyl-CoA[x]
Left to rightBalancedEC 5.3.3.8Omega-6 fatty acid metabolismHuman-GEM MAR03462
H2O[x] + trans-2-cis,cis,cis-8,11,14-eicosatetraenoyl-CoA[x] = 3(S)-hydroxy-dihomo-gamma-linolenoyl-CoA[x]
Left to rightBalancedEC 4.2.1.17Omega-6 fatty acid metabolismHuman-GEM MAR03463
3(S)-hydroxy-dihomo-gamma-linolenoyl-CoA[x] + NAD+[x] = 3-oxo-dihomo-gamma-linolenoyl-CoA[x] + H+[x] + NADH[x]
Left to rightBalancedEC 1.1.1.35, 1.1.1.211Omega-6 fatty acid metabolismHuman-GEM MAR03464
3(S)-hydroxy-docosa-7,10,13,16-all-cis-tetraenoyl-CoA[r] = (2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA[r] + H2O[r]
ReversibleBalancedEC 2.3.1.199Fatty acid oxidationHuman-GEM MAR03465
FAD[x] + gamma-linolenoyl-CoA[x] = (2E,6Z,9Z,12Z)-octadecatetraenoyl-CoA[x] + FADH2[x]
Left to rightBalancedEC 1.3.3.6Omega-6 fatty acid metabolismHuman-GEM MAR03466
(2E,6Z,9Z,12Z)-octadecatetraenoyl-CoA[x] + H2O[x] = 3(S)-hydroxy-(6Z,9Z,12Z)-octadecatrienoyl-CoA[x]
Left to rightBalancedEC 4.2.1.17Omega-6 fatty acid metabolismHuman-GEM MAR03467
3(S)-hydroxy-(6Z,9Z,12Z)-octadecatrienoyl-CoA[x] + NAD+[x] = 3-oxo-(6Z,9Z,12Z)-octadecatrienoyl-CoA[x] + H+[x] + NADH[x]
ReversibleBalancedEC 1.1.1.35, 1.1.1.211Omega-6 fatty acid metabolismHuman-GEM MAR03468
(4Z,7Z,10Z)-hexadecatrienoyl-CoA[x] + acetyl-CoA[x] = 3-oxo-(6Z,9Z,12Z)-octadecatrienoyl-CoA[x] + CoA[x]
ReversibleBalancedEC 2.3.1.16Omega-6 fatty acid metabolismHuman-GEM MAR03469
(4Z,7Z,10Z)-hexadecatrienoyl-CoA[x] + FAD[x] = (2E,4Z,7Z,10Z)-hexadecatetraenoyl-CoA[x] + FADH2[x]
Left to rightBalancedEC 1.3.3.6Omega-6 fatty acid metabolismHuman-GEM MAR03470
(2E,4Z,7Z,10Z)-hexadecatetraenoyl-CoA[x] + H+[x] + NADPH[x] = (3Z,7Z,10Z)-hexadecatrienoyl-CoA[x] + NADP+[x]
ReversibleBalancedEC 1.3.1.34Omega-6 fatty acid metabolismHuman-GEM MAR03471
(3Z,7Z,10Z)-hexadecatrienoyl-CoA[x] = trans,cis,cis-2,7,10-hexadecatrienoyl-CoA[x]
Left to rightBalancedEC 5.3.3.8Omega-6 fatty acid metabolismHuman-GEM MAR03472
ADP[c] + AMP[x] = ADP[x] + AMP[c]
ReversibleBalancedTransportTransport reactionsHuman-GEM MAR03473
3-oxo-tetracosa-9,12,15,18-all-cis-tetraenoyl-CoA[r] + H+[r] + NADPH[r] = 3(S)-hydroxy-tetracosa-12,15,18,21-all-cis-tetraenoyl-CoA[r] + NADP+[r]
ReversibleBalancedEC 6.2.1.3Fatty acid oxidationHuman-GEM MAR03474
acetyl-CoA[x] + H2O[x] = acetate[x] + CoA[x] + H+[x]
Left to rightBalancedEC 3.1.2.27Acyl-CoA hydrolysisHuman-GEM MAR03475
formyl-CoA[x] + H2O[x] = CoA[x] + formate[x] + H+[x]
Left to rightBalancedAcyl-CoA hydrolysisHuman-GEM MAR03476
formyl-CoA[c] + H2O[c] = CoA[c] + formate[c] + H+[c]
Left to rightBalancedAcyl-CoA hydrolysisHuman-GEM MAR03477
(3R)-phytanic acid[c] = (3R)-phytanic acid[x]
Left to rightBalancedTransportTransport reactionsHuman-GEM MAR03478
3(S)-hydroxy-tetracosa-12,15,18,21-all-cis-tetraenoyl-CoA[r] = 2-trans-9,12,15,18-all-cis-tetracosapentaenoyl-CoA[r] + H2O[r]
ReversibleBalancedEC 2.3.1.199Fatty acid oxidationHuman-GEM MAR03479
ATP[c] + CoA[c] + (3R)-phytanic acid[c] = AMP[c] + (3R)-phytanoyl-CoA[c] + PPi[c]
Left to rightBalancedEC 6.2.1.24, 6.2.1.3Beta oxidation of phytanic acid (peroxisomal)Human-GEM MAR03480
ATP[c] + 2 H2O[c] + (3R)-phytanoyl-CoA[c] = ADP[c] + CoA[c] + 2 H+[c] + (3R)-phytanic acid[x] + Pi[c]
ReversibleBalancedTransport reactionsHuman-GEM MAR03481