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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Reactions
Reach

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

29,951–30,000 of 31,435, by identifier

(R)-norprotosinomenine + S-adenosyl-L-methionine = (R)-6-O-methylnorprotosinomenine + S-adenosyl-L-homocysteine + H(+)
Direction not assertedBalancedRhea 80699
5-chlorosalicylate + NADH + O2 + 2 H(+) = 4-chlorocatechol + CO2 + NAD(+) + H2O
Direction not assertedBalancedRhea 80703
4-chlorosalicylate + NADH + O2 + 2 H(+) = 4-chlorocatechol + CO2 + NAD(+) + H2O
Direction not assertedBalancedRhea 80707
3-chlorosalicylate + NADH + O2 + 2 H(+) = 3-chlorocatechol + CO2 + NAD(+) + H2O
Direction not assertedBalancedRhea 80711
2-(2-chloro-2,5-dihydro-4-methyl-5-oxofuryl)acetate = (2Z,4E)-4-chloro-2-methylmuconate + H(+)
Direction not assertedBalancedRhea 80715
a di-trans,poly-cis-polyprenol + NAD(+) = a di-trans,poly-cis-polyprenal + NADH + H(+)
Left to rightBalance undeterminableRhea 80719

a di-trans,poly-cis-polyprenol + NADP(+) = a di-trans,poly-cis-polyprenal + NADPH + H(+)

Left to rightBalance undeterminableRhea 80723

a di-trans,poly-cis-dolichal + NADP(+) = a di-trans,poly-cis-polyprenal + NADPH + H(+)

Right to leftBalance undeterminableRhea 80727

a di-trans,poly-cis-dolichol + NADP(+) = a di-trans,poly-cis-dolichal + NADPH + H(+)

Right to leftBalance undeterminableRhea 80731

a di-trans,poly-cis-dolichol + NAD(+) = a di-trans,poly-cis-dolichal + NADH + H(+)

Right to leftBalance undeterminableRhea 80735

2-(2-chloro-2,5-dihydro-4-methyl-5-oxofuryl)acetate = cis-2-methyl-4-carboxylatomethylenebut-2-en-1,4-olide + chloride + H(+)

Direction not assertedBalancedRhea 80739

2-(2-chloro-2,5-dihydro-4-methyl-5-oxofuryl)acetate = trans-2-methyl-4-carboxylatomethylenebut-2-en-1,4-olide + chloride + H(+)

Direction not assertedBalancedRhea 80743

2-(2,4-dichloro-5-oxo-2,5-dihydrofuryl)acetate = trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide + chloride + H(+)

Direction not assertedBalancedRhea 80747

a neolactoside nLc6Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a neolactoside VI(3)-alpha-NeuNAc-nLc6Cer(d18:1(4E)) + CMP + H(+)

Left to rightBalance undeterminableRhea 80751

a neolactoside nLc6Cer + CMP-N-acetyl-beta-neuraminate = a neolactoside VI(3)-alpha-NeuNAc-nLc6Cer + CMP + H(+)

Direction not assertedBalance undeterminableRhea 80755

bis(2-hydroxyethyl) terephthalate + H2O = 4-[(2-hydroxyethoxy)carbonyl]benzoate + ethylene glycol + H(+)

Direction not assertedBalancedRhea 80759

an Ac-O-9-sialoglycoconjugate + H2O = a sialoglycoconjugate + acetate + H(+)

Left to rightBalance undeterminableRhea 80763

an alpha-ketoester + NADPH + H(+) = an (R)-hydroxy ester + NADP(+)

Direction not assertedBalance undeterminableRhea 80767

L-tryptophan + S-adenosyl-L-methionine = N(alpha)-methyl-L-tryptophan + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 80771

(S)-epichlorohydrin + H2O = (S)-3-chloro-1,2-propanediol

Direction not assertedBalancedRhea 80779

(R)-epichlorohydrin + H2O = (R)-3-chloro-1,2-propanediol

Direction not assertedBalancedRhea 80783

1,2-epoxy-9-decene + H2O = dec-9-ene-1,2-diol

Direction not assertedBalancedRhea 80787

(R)-styrene oxide + H2O = (R)-styrene glycol

Direction not assertedBalancedRhea 80791

(S)-styrene oxide + H2O = (S)-styrene glycol

Direction not assertedBalancedRhea 80795

3,4-epoxy-1-cyclohexene + H2O = cyclohex-3-ene-1,2-diol

Direction not assertedBalancedRhea 80799

GDGT-0 + AH2 + 2 S-adenosyl-L-methionine = GMGT-0 + 2 5'-deoxyadenosine + 2 L-methionine + A + 2 H(+)

Direction not assertedBalancedRhea 80803

4-methyl-2-oxopentanoate + S-adenosyl-L-methionine = (3R)-3,4-dimethyl-2-oxopentanoate + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 80807

5-phospho-alpha-D-ribose 1-diphosphate + H2O = alpha-D-ribose 1,5-bisphosphate + phosphate + H(+)

Left to rightBalancedRhea 80811

a medium-chain fatty aldehyde + NADP(+) + H2O = a medium-chain fatty acid + NADPH + 2 H(+)

Left to rightBalance undeterminableRhea 80815

nonanal + NADP(+) + H2O = nonanoate + NADPH + 2 H(+)

Left to rightBalancedRhea 80819

a fatty aldehyde + NADP(+) + H2O = a fatty acid + NADPH + 2 H(+)

Direction not assertedBalance undeterminableRhea 80823

dihydrophloroglucinol + H2O = (S)-3-hydroxy-5-oxohexanoate

Direction not assertedBalancedRhea 80827

(S)-3-hydroxy-5-oxohexanoate = acetone + 3-oxopropanoate

Direction not assertedBalancedRhea 80831

aldehydo-N-acetyl-D-mannosamine 6-phosphate + phosphoenolpyruvate + H2O = N-acetylneuraminate 9-phosphate + phosphate

Left to rightBalancedRhea 80835

N-acetylneuraminate 9-phosphate + H2O = N-acetylneuraminate + phosphate

Left to rightBalancedRhea 80839

N-acetylneuraminate + CTP = CMP-N-acetyl-beta-neuraminate + diphosphate

Direction not assertedBalancedRhea 80843

N(alpha)-methyl-L-tryptophan + S-adenosyl-L-methionine = N(alpha),N(alpha)-dimethyl-L-tryptophan + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 80847

N(alpha),N(alpha)-dimethyl-L-tryptophan + S-adenosyl-L-methionine = N(alpha),N(alpha),N(alpha)-trimethyl-L-tryptophan + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 80851

a 2-hydroxy-fatty acyl-CoA + sphinganine = an N-(2-hydroxyacyl)-sphinganine + CoA + H(+)

Direction not assertedBalance undeterminableRhea 80859

triacetate lactone + (2E,6E,10E)-geranylgeranyl diphosphate = (2E,6E,10E)-geranylgeranyl-triacetate lactone + diphosphate

Direction not assertedBalancedRhea 80863

(2E,6E,10E)-geranylgeranyl-triacetate lactone + AH2 + O2 = (S)-(2E,6E,10E)-epoxygeranylgeranyl-triacetate lactone + A + H2O

Direction not assertedBalancedRhea 80867

(S)-(2E,6E,10E)-epoxygeranylgeranyl-triacetate lactone = sartorypyrone F

Direction not assertedBalancedRhea 80871

(S)-(2E,6E,10E)-epoxygeranylgeranyl-triacetate lactone = sartorypyrone D

Direction not assertedBalancedRhea 80875

sartorypyrone F + acetyl-CoA = sartorypyrone G + CoA

Direction not assertedBalancedRhea 80879

sartorypyrone D + acetyl-CoA = sartorypyrone A + CoA

Direction not assertedBalancedRhea 80883

formate(in) + H(+)(in) = formate(out) + H(+)(out)

Direction not assertedBalancedTransportRhea 80887

O-phospho-L-homoserine + L-cysteine = L,L-cystathionine + phosphate

Direction not assertedBalancedRhea 80891

trans,octa-cis-decaprenylphospho-beta-D-ribofuranose 5-phosphate + H2O = trans,octa-cis-decaprenylphospho-beta-D-ribofuranose + phosphate

Direction not assertedBalancedRhea 80895

17-dehydropreakuammicine + H2O = norfluorocurarine + methanol + CO2

Direction not assertedBalancedRhea 80899

(19E)-cur-19-en-17-al + NADP(+) = norfluorocurarine + NADPH + H(+)

Direction not assertedBalancedRhea 80903

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