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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Proteins
Interactions
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Reactions
Reach

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Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

28,251–28,300 of 31,435, by identifier

histamine(out) = histamine(in)
Direction not assertedBalancedTransportRhea 73879
guanidine(out) = guanidine(in)
Direction not assertedBalancedTransportRhea 73883
chloride(out) + Na(+)(out) = chloride(in) + Na(+)(in)
Direction not assertedBalancedTransportRhea 73887
spermidine + L-glutamate + ATP = gamma-L-glutamylspermidine + ADP + phosphate + H(+)
Direction not assertedBalancedRhea 73891
spermine + L-glutamate + ATP = gamma-L-glutamylspermine + ADP + phosphate + H(+)
Direction not assertedBalancedRhea 73895
cadaverine + L-glutamate + ATP = gamma-L-glutamylcadaverine + ADP + phosphate + H(+)
Direction not assertedBalancedRhea 73899
ethanolamine + L-glutamate + ATP = gamma-L-glutamylethanolamide + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 73903

4-hydroxy-N,N,N-trimethyltryptamine + ATP = aeruginascin + ADP + H(+)

Direction not assertedBalancedRhea 73907

psilocin + ATP = psilocybin + ADP + H(+)

Direction not assertedBalancedRhea 73911

6 malonyl-CoA + acetyl-CoA + 4 H(+) = 2-(2,4-dihydroxy-6-oxidobenzoyl)-5-hydroxy-3-methylbenzenolate + 6 CO2 + 7 CoA + H2O

Direction not assertedBalancedRhea 73915

2-(2,4-dihydroxy-6-oxidobenzoyl)-5-hydroxy-3-methylbenzenolate + H(+) = norlichexanthone + H2O

Direction not assertedBalancedRhea 73919

2-(2,4-dihydroxy-6-oxidobenzoyl)-5-hydroxy-3-methylbenzenolate + S-adenosyl-L-methionine = griseophenone D + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 73923

griseophenone D + S-adenosyl-L-methionine = griseophenone C + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 73927

griseophenone C + FADH2 + chloride + O2 = griseophenone B + FAD + 2 H2O + H(+)

Direction not assertedBalancedRhea 73931

griseophenone B + reduced [NADPH--hemoprotein reductase] + O2 + H(+) = desmethyl-dehydrogriseofulvin + oxidized [NADPH--hemoprotein reductase] + 2 H2O

Direction not assertedBalance undeterminableRhea 73935

desmethyl-dehydrogriseofulvin + S-adenosyl-L-methionine = dehydrogriseofulvin + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 73939

dehydrogriseofulvin + NADPH + H(+) = griseofulvin + NADP(+)

Direction not assertedBalancedRhea 73943

(2E)-geranyl diphosphate = (4E,6E)-allo-ocimene + diphosphate

Direction not assertedBalancedRhea 73947

(2E,6E)-farnesyl diphosphate = beta-maaliene + diphosphate

Direction not assertedBalancedRhea 73951

3,4-dihydroxystyrene + NADH + H(+) = 4-ethylcatechol + NAD(+)

Direction not assertedBalancedRhea 73955

2-methoxy-4-vinylphenol + NADH + H(+) = 4-ethyl-2-methoxyphenol + NAD(+)

Direction not assertedBalancedRhea 73959

(2E,6E)-farnesyl diphosphate = aristolene + diphosphate

Direction not assertedBalancedRhea 73963

1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoate + H(+)

Left to rightBalancedRhea 73967

a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + a fatty acid + H(+)

Left to rightBalance undeterminableRhea 73971

a 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+)

Left to rightBalance undeterminableRhea 73975

(2E,6E)-farnesyl diphosphate = calarene + diphosphate

Direction not assertedBalancedRhea 73979

(2E,6E)-farnesyl diphosphate = (-)-beta-barbatene + diphosphate

Direction not assertedBalancedRhea 73983

(2E,6E)-farnesyl diphosphate + H2O = discoidol + diphosphate

Direction not assertedBalancedRhea 73987

geranylgeranyl diphosphate = beta-araneosene + diphosphate

Direction not assertedBalancedRhea 73991

geranylgeranyl diphosphate + H2O = (S)-(+)-nephthenol + diphosphate

Direction not assertedBalancedRhea 73995

quinolinone B + dimethylallyl diphosphate = peniprequinolone + diphosphate

Direction not assertedBalancedRhea 73999

peniprequinolone + A = yaequinolone E + AH2

Direction not assertedBalancedRhea 74003

yaequinolone E + dimethylallyl diphosphate + H2O = [(1'E)-3'-hydroxy-3',7'-dimethylocta-1',6'-dien-1'-yl]-quinolinone B + diphosphate

Direction not assertedBalancedRhea 74007

[(1'E)-3'-hydroxy-3',7'-dimethylocta-1',6'-dien-1'-yl]-quinolinone B + NADPH + O2 + H(+) = [(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B + NADP(+) + H2O

Direction not assertedBalancedRhea 74011

4-hydroxybenzoate + phosphate + H(+) = phenyl phosphate + CO2 + H2O

Direction not assertedBalancedRhea 74015

L-alanine(in) + glycine(out) = L-alanine(out) + glycine(in)

Direction not assertedBalancedTransportRhea 74019

L-serine(out) + L-alanine(in) = L-serine(in) + L-alanine(out)

Direction not assertedBalancedTransportRhea 74023

L-threonine(out) + L-alanine(in) = L-threonine(in) + L-alanine(out)

Direction not assertedBalancedTransportRhea 74027

L-cysteine(out) + L-alanine(in) = L-cysteine(in) + L-alanine(out)

Direction not assertedBalancedTransportRhea 74031

D-serine(out) + L-alanine(in) = D-serine(in) + L-alanine(out)

Direction not assertedBalancedTransportRhea 74035

D-alanine(out) + L-alanine(in) = D-alanine(in) + L-alanine(out)

Direction not assertedBalancedTransportRhea 74039

L-methionine(out) + L-alanine(in) = L-methionine(in) + L-alanine(out)

Direction not assertedBalancedTransportRhea 74043

L-valine(out) + L-alanine(in) = L-valine(in) + L-alanine(out)

Direction not assertedBalancedTransportRhea 74047

D-threonine(out) + L-alanine(in) = D-threonine(in) + L-alanine(out)

Direction not assertedBalancedTransportRhea 74051

D-cysteine(out) + L-alanine(in) = D-cysteine(in) + L-alanine(out)

Direction not assertedBalancedTransportRhea 74055

beta-alanine(out) + L-alanine(in) = beta-alanine(in) + L-alanine(out)

Direction not assertedBalancedTransportRhea 74059

2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)

Direction not assertedBalancedTransportRhea 74063

an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + ADP-L-glycero-beta-D-manno-heptose = an L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ADP + H(+)

Direction not assertedBalance undeterminableRhea 74067

an L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ADP-L-glycero-beta-D-manno-heptose = an L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ADP + H(+)

Direction not assertedBalance undeterminableRhea 74071

phylloquinone + NADH + H(+) = phylloquinol + NAD(+)

Left to rightBalancedRhea 74075

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