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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
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Reactions
Reach

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Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

27,451–27,500 of 31,435, by identifier

4-hydroxy-L-proline(in) + H(+)(in) = 4-hydroxy-L-proline(out) + H(+)(out)
Direction not assertedBalancedTransportRhea 70663
a fatty acyl-[ACP] + L-lysyl-[protein] = N(6)-(fatty acyl)-L-lysyl-[protein] + holo-[ACP] + H(+)
Direction not assertedBalance undeterminableRhea 70667
N-terminal glycyl-L-lysyl-[protein] + tetradecanoyl-CoA = N-terminal glycyl-(N(6)-tetradecanoyl)-L-lysyl-[protein] + CoA + H(+)
Left to rightBalance undeterminableRhea 70671
Met-enkephalin-Arg-Phe + H2O = L-arginyl-L-phenylalanine + Met-enkephalin
Left to rightBalancedRhea 70675
glycine betaine(in) + H(+)(in) = glycine betaine(out) + H(+)(out)
Direction not assertedBalancedTransportRhea 70679
(R)-normetanephrine + S-adenosyl-L-methionine = (R)-metanephrine + S-adenosyl-L-homocysteine + H(+)
Left to rightBalancedRhea 70683

4-aminobutanoate(out) + chloride(out) + 2 Na(+)(out) = 4-aminobutanoate(in) + chloride(in) + 2 Na(+)(in)

ReversibleBalancedTransportRhea 70687

glycine(out) + chloride(out) + 2 Na(+)(out) = glycine(in) + chloride(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 70691

glycine(out) + chloride(out) + 3 Na(+)(out) = glycine(in) + chloride(in) + 3 Na(+)(in)

Direction not assertedBalancedTransportRhea 70695

K(+)(in) + L-glutamate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-glutamate(in) + 3 Na(+)(in) + H(+)(in)

Direction not assertedBalancedTransportRhea 70699

D-cycloserine(in) + H(+)(in) = D-cycloserine(out) + H(+)(out)

Direction not assertedBalancedTransportRhea 70703

6-sulfo-beta-D-quinovose = 6-sulfo-D-rhamnose

Direction not assertedBalancedRhea 70707

D-alanine(in) = D-alanine(out)

Direction not assertedBalancedTransportRhea 70711

glycine(in) = glycine(out)

Direction not assertedBalancedTransportRhea 70715

L-alanine(in) = L-alanine(out)

ReversibleBalancedTransportRhea 70719

sitosterol(out) = sitosterol(in)

Direction not assertedBalancedTransportRhea 70723

3-(6-sulfo-alpha-D-quinovosyl)glycerol + H2O = 6-sulfo-alpha-D-quinovose + glycerol

Direction not assertedBalancedRhea 70727

4-aminobutanoate(out) + chloride(out) + 3 Na(+)(out) = 4-aminobutanoate(in) + chloride(in) + 3 Na(+)(in)

Left to rightBalancedTransportRhea 70731

glycine betaine(out) + chloride(out) + 2 Na(+)(out) = glycine betaine(in) + chloride(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 70735

1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-homocysteine + H(+)

Left to rightBalancedRhea 70739

1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-homocysteine + H(+)

Left to rightBalancedRhea 70743

1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + S-adenosyl-L-homocysteine + H(+)

Left to rightBalancedRhea 70747

1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-homocysteine + H(+)

Left to rightBalancedRhea 70751

1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-homocysteine + H(+)

Left to rightBalancedRhea 70755

1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + S-adenosyl-L-homocysteine + H(+)

Left to rightBalancedRhea 70759

1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-homocysteine + H(+)

Left to rightBalancedRhea 70763

1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-homocysteine + H(+)

Left to rightBalancedRhea 70767

1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + S-adenosyl-L-homocysteine + H(+)

Left to rightBalancedRhea 70771

6-sulfo-D-quinovose + FMNH2 + O2 = 6-dehydro-D-glucose + FMN + sulfite + H2O + 2 H(+)

Direction not assertedBalancedRhea 70775

D-glucose + NADP(+) = 6-dehydro-D-glucose + NADPH + H(+)

Direction not assertedBalancedRhea 70779

L-aspartate(in) + L-glutamate(out) + H(+)(out) = L-aspartate(out) + L-glutamate(in) + H(+)(in)

Direction not assertedBalancedTransportRhea 70783

L-citrulline(in) + L-ornithine(out) + H(+)(in) = L-citrulline(out) + L-ornithine(in) + H(+)(out)

Direction not assertedBalancedTransportRhea 70787

L-ornithine(out) + H(+)(in) = L-ornithine(in) + H(+)(out)

Direction not assertedBalancedTransportRhea 70791

L-lysine(out) + H(+)(in) = L-lysine(in) + H(+)(out)

Direction not assertedBalancedTransportRhea 70795

L-ornithine(out) + L-lysine(in) = L-ornithine(in) + L-lysine(out)

Direction not assertedBalancedTransportRhea 70799

6-deoxy-6-sulfo-D-fructose + D-glyceraldehyde 3-phosphate = 4-deoxy-4-sulfo-D-erythrose + D-xylulose 5-phosphate

Direction not assertedBalancedRhea 70803

4-deoxy-4-sulfo-D-erythrose = 4-deoxy-4-sulfo-D-erythrulose

Direction not assertedBalancedRhea 70807

4-deoxy-4-sulfo-D-erythrulose + D-glyceraldehyde 3-phosphate = sulfoacetaldehyde + D-xylulose 5-phosphate

Direction not assertedBalancedRhea 70811

L-histidine(in) + L-ornithine(out) + H(+)(in) = L-histidine(out) + L-ornithine(in) + H(+)(out)

Direction not assertedBalancedTransportRhea 70815

L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)

Direction not assertedBalancedTransportRhea 70819

L-lysine(out) + L-arginine(in) = L-lysine(in) + L-arginine(out)

Left to rightBalancedTransportRhea 70827

L-leucine(out) + L-arginine(in) + Na(+)(out) = L-leucine(in) + L-arginine(out) + Na(+)(in)

Direction not assertedBalancedTransportRhea 70831

L-arginine(in) + L-glutamine(out) + Na(+)(out) = L-arginine(out) + L-glutamine(in) + Na(+)(in)

Direction not assertedBalancedTransportRhea 70835

L-histidine(out) + L-arginine(in) + Na(+)(out) = L-histidine(in) + L-arginine(out) + Na(+)(in)

Direction not assertedBalancedTransportRhea 70839

L-arginine(in) + L-methionine(out) + Na(+)(out) = L-arginine(out) + L-methionine(in) + Na(+)(in)

Direction not assertedBalancedTransportRhea 70843

L-cysteine(out) + L-arginine(in) + Na(+)(out) = L-cysteine(in) + L-arginine(out) + Na(+)(in)

Direction not assertedBalancedTransportRhea 70847

K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)

Direction not assertedBalancedTransportRhea 70851

L-serine(in) + L-glutamine(out) + Na(+)(out) = L-serine(out) + L-glutamine(in) + Na(+)(in)

Direction not assertedBalancedTransportRhea 70855

L-asparagine(in) + L-glutamine(out) + Na(+)(out) = L-asparagine(out) + L-glutamine(in) + Na(+)(in)

Direction not assertedBalancedTransportRhea 70859

L-threonine(in) + L-glutamine(out) + Na(+)(out) = L-threonine(out) + L-glutamine(in) + Na(+)(in)

Direction not assertedBalancedTransportRhea 70863

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