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ReactionsRhea and Human-GEM, by subsystem
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Reference

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

26,601–26,650 of 31,435, by identifier

(E)-4-hydroxynon-2-enal + NAD(+) + H2O = (E)-4-hydroxynon-2-enoate + NADH + 2 H(+)
Left to rightBalancedRhea 67248
malonaldehyde + NAD(+) + H2O = 3-oxopropanoate + NADH + 2 H(+)
Left to rightBalancedRhea 67252
propanal + NAD(+) + H2O = propanoate + NADH + 2 H(+)
Left to rightBalancedRhea 67256
(E)-hept-2-enal + NAD(+) + H2O = (E)-hept-2-enoate + NADH + 2 H(+)
Direction not assertedBalancedRhea 67260
(2S,4S)-4-hydroxy-4-methylglutamate + 8 malonyl-CoA + 3 S-adenosyl-L-methionine + ATP + 8 NADPH + 11 H(+) = (2S)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate + AMP + 3 S-adenosyl-L-homocysteine + 8 CO2 + diphosphate + 8 NADP(+) + 8 CoA + 6 H2O
Direction not assertedBalancedRhea 67264
(2S)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate = sch 210972
Direction not asserted

Balanced

Rhea 67268

1'-[1-acyl-2-(9-hydroxy-(10E,12Z)-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1,2-diacyl-sn-glycero-3-phospho]-glycerol + H2O = 9-hydroxy-(10E,12Z)-octadecadienoate + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + H(+)

Left to rightBalance undeterminableRhea 67272

hexanal + NAD(+) + H2O = hexanoate + NADH + 2 H(+)

Left to rightBalancedRhea 67276

(2R,4S,6E,8E,10E)-1-(4-methoxy-5-methylidene-2-oxo-2,5-dihydrofuran-3-yl)-2,4-dimethyldodeca-6,8,10-triene-1,5-dione = (1R,3R,6S,7E,10S,12R)-17-methoxy-3,10,12-trimethyl-16-oxatricyclo[12.2.1.0(1,6)]heptadeca-4,7,14(17)-triene-9,13,15-trione

Direction not assertedBalancedRhea 67280

(2R,4S,6E,8E,10E)-1-(4-hydroxy-5-methylidene-2-oxo-2,5-dihydrofuran-3-yl)-2,4-dimethyldodeca-6,8,10-triene-1,5-dione = (1R,3R,6S,7E,10S,12R)-17-hydroxy-3,10,12-trimethyl-16-oxatricyclo[12.2.1.0(1,6)]heptadeca-4,7,14(17)-triene-9,13,15-trione

Direction not assertedBalancedRhea 67284

L-leucine + 8 malonyl-CoA + 4 S-adenosyl-L-methionine + ATP + 9 NADPH + 12 H(+) = (5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one + AMP + 4 S-adenosyl-L-homocysteine + 8 CO2 + diphosphate + 9 NADP(+) + 8 CoA + 7 H2O

Direction not assertedBalancedRhea 67288

(5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one = (3Z)-3-[(2E,6R,8E,10E,12E)-1-hydroxy-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraen-1-ylidene]-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one

Direction not assertedBalancedRhea 67292

(3Z)-3-[(2E,6R,8E,10E,12E)-1-hydroxy-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraen-1-ylidene]-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one + O2 = (5Z)-5-(2-methylpropylidene)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one + H2O2

Direction not assertedBalancedRhea 67296

(5S)-3-[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-5-(2-methylpropyl)-2,5-dihydro-1H-pyrrol-2-one = 3-{[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl](hydroxy)methylidene}-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one

Direction not assertedBalancedRhea 67300

3-{[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl](hydroxy)methylidene}-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one + O2 = myceliothermophin E + H2O2

Direction not assertedBalancedRhea 67304

(5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one = (5S)-3-[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-5-(2-methylpropyl)-2,5-dihydro-1H-pyrrol-2-one

Direction not assertedBalancedRhea 67308

(5Z)-5-(2-methylpropylidene)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one = myceliothermophin E

Direction not assertedBalancedRhea 67312

(2S,4R)-4-hydroxy-4-methylglutamate + 8 malonyl-CoA + 3 S-adenosyl-L-methionine + ATP + 8 NADPH + 11 H(+) = (2R)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate + AMP + 3 S-adenosyl-L-homocysteine + 8 CO2 + diphosphate + 8 NADP(+) + 8 CoA + 6 H2O

Direction not assertedBalancedRhea 67316

(2R)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate = sch 210971

Direction not assertedBalancedRhea 67320

L-serine + 7 malonyl-CoA + acetyl-CoA + 2 S-adenosyl-L-methionine + ATP + 8 NADPH + 11 H(+) = (5S)-3-[(2E,6R,8E,10E,12E)-2,6-dimethyltetradeca-2,8,10,12-tetraenoyl]-5-(hydroxymethyl)pyrrolidine-2,4-dione + AMP + 2 S-adenosyl-L-homocysteine + 7 CO2 + diphosphate + 8 NADP(+) + 8 CoA + 6 H2O

Direction not assertedBalancedRhea 67324

(5S)-3-[(2E,6R,8E,10E,12E)-2,6-dimethyltetradeca-2,8,10,12-tetraenoyl]-5-(hydroxymethyl)pyrrolidine-2,4-dione = trichosetin

Direction not assertedBalancedRhea 67328

13-cis-retinal + NAD(+) + H2O = 13-cis-retinoate + NADH + 2 H(+)

Left to rightBalancedRhea 67332

kaempferol 3-O-beta-D-glucoside + malonyl-CoA = kaempferol 3-O-(6-O-malonyl-beta-D-glucoside) + CoA

Direction not assertedBalancedRhea 67336

quercetin 3-O-beta-D-glucoside + malonyl-CoA = quercetin 3-O-(6-O-malonyl-beta-D-glucoside) + CoA

Direction not assertedBalancedRhea 67340

kaempferol 7-O-beta-D-glucoside + malonyl-CoA = kaempferol 7-O-(6-O-malonyl-beta-D-glucoside) + CoA

Direction not assertedBalancedRhea 67344

apigenin 7-O-beta-D-glucoside + malonyl-CoA = apigenin 7-O-(6-O-malonyl-beta-D-glucoside) + CoA

Direction not assertedBalancedRhea 67348

rhaponticin + malonyl-CoA = 6-O-malonyl-rhaponticin + CoA

Direction not assertedBalancedRhea 67352

(2S)-naringenin 7-O-beta-D-glucoside + malonyl-CoA = (2S)-naringenin 7-O-(6-O-malonyl-beta-D-glucoside) + CoA

Direction not assertedBalancedRhea 67356

L-threonyl-L-threonine + H2O = 2 L-threonine

Left to rightBalancedRhea 67360

L-threonyl-L-serine + H2O = L-threonine + L-serine

Left to rightBalancedRhea 67364

N-acetyl-L-glutamine + H2O = L-glutamine + acetate

Left to rightBalancedRhea 67368

L-seryl-L-threonine + H2O = L-threonine + L-serine

Left to rightBalancedRhea 67372

glycyl-L-histidine + H2O = L-histidine + glycine

Left to rightBalancedRhea 67376

L-alanyl-L-cysteine + H2O = L-cysteine + L-alanine

Left to rightBalancedRhea 67380

5beta-cholestane-3alpha,7alpha-diol + reduced [NADPH--hemoprotein reductase] + O2 = 5beta-cholestane-3alpha,7alpha,25-triol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 67384

L-cysteinyl-[myelin proteolipid protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[myelin proteolipid protein] + CoA

Direction not assertedBalance undeterminableRhea 67388

2-oxo-ATP + H2O = 2-oxo-AMP + diphosphate + H(+)

Left to rightBalancedRhea 67392

5beta-cholestane-3alpha,7alpha,12alpha-triol + reduced [NADPH--hemoprotein reductase] + O2 = 5beta-cholestane-3alpha,7alpha,12alpha,25-tetrol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 67396

(2E,6E)-farnesyl diphosphate = allo-aromadendrene + diphosphate

Direction not assertedBalancedRhea 67400

gamma-terpinene + 2 reduced [NADPH--hemoprotein reductase] + 2 O2 = carvacrol + 2 oxidized [NADPH--hemoprotein reductase] + 3 H2O + 2 H(+)

Direction not assertedBalance undeterminableRhea 67404

gamma-terpinene + 2 reduced [NADPH--hemoprotein reductase] + 2 O2 = thymol + 2 oxidized [NADPH--hemoprotein reductase] + 3 H2O + 2 H(+)

Direction not assertedBalance undeterminableRhea 67408

alpha-terpinene + 2 reduced [NADPH--hemoprotein reductase] + 2 O2 = carvacrol + 2 oxidized [NADPH--hemoprotein reductase] + 3 H2O + 2 H(+)

Direction not assertedBalance undeterminableRhea 67412

(4R)-limonene + reduced [NADPH--hemoprotein reductase] + O2 = (1R,6S)-isopiperitenol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 67416

a glycerophospholipid + H2O = a 1-acyl-sn-glycero-3-phospholipid + a fatty acid + H(+)

Direction not assertedBalance undeterminableRhea 67420

a glycerophospholipid + H2O = a 2-acyl-sn-glycero-3-phospholipid + a fatty acid + H(+)

Direction not assertedBalance undeterminableRhea 67424

a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 2-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a fatty acid + H(+)

Left to rightBalance undeterminableRhea 67428

1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine

Direction not assertedBalancedRhea 67432

1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-sn-glycero-3-phosphocholine = 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine

Direction not assertedBalancedRhea 67436

N-acetyl-L-methionine + H2O = L-methionine + acetate

Left to rightBalancedRhea 67440

an (R)-2-hydroxy-long-chain-fatty acyl-CoA = a long-chain fatty aldehyde + formyl-CoA

Left to rightBalance undeterminableRhea 67444

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