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CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Reactions
Reach

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

2,601–2,650 of 18,558 reactions from Rhea

a [peptide]-C-terminal (2S)-2-hydroxyglycine = a [peptide]-C-terminal amide + glyoxylate
Direction not assertedBalance undeterminableRhea 20924
[DsbA protein]-dithiol + a quinone = [DsbA protein]-disulfide + a quinol
Direction not assertedBalance undeterminableRhea 20928
L-erythrulose 1-phosphate = dihydroxyacetone phosphate + formaldehyde
Direction not assertedBalancedRhea 20932
2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O
Direction not assertedBalancedRhea 20936
1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+)
ReversibleBalancedRhea 20940
theobromine + S-adenosyl-L-methionine = caffeine + S-adenosyl-L-homocysteine + H(+)
Direction not assertedBalancedRhea 20944
3-sulfopyruvate + H(+) = sulfoacetaldehyde + CO2

Direction not assertedBalancedRhea 20948

N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose = beta-D-glucosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + UDP + H(+)

Direction not assertedBalancedRhea 20952

2-phenylacetate + ATP + CoA = phenylacetyl-CoA + AMP + diphosphate

Direction not assertedBalancedRhea 20956

1D-myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,3,5,6-pentakisphosphate + phosphate

Left to rightBalancedRhea 20960

L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate

Direction not assertedBalancedRhea 20964

L-arabinonate = 2-dehydro-3-deoxy-L-arabinonate + H2O

Direction not assertedBalancedRhea 20968

a 1-O-alkyl-sn-glycero-3-phosphoethanolamine + a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine = a 1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + a 1-O-alkyl-sn-glycero-3-phosphocholine

Direction not assertedBalance undeterminableRhea 20972

a primary nitroalkane + O2 + H2O = an aldehyde + nitrite + H2O2 + H(+)

Direction not assertedBalance undeterminableRhea 20976

2 (4Z,15Z)-bilirubin IXalpha + O2 = 2 biliverdin IXalpha + 2 H2O

Direction not assertedBalancedRhea 20980

a sphingomyelin + H2O = an N-acylsphing-4-enine 1-phosphate + choline + H(+)

Direction not assertedBalance undeterminableRhea 20984

ATP + 2 H2O = AMP + 2 phosphate + 2 H(+)

Left to rightBalancedRhea 20988

16-hydroxytabersonine + S-adenosyl-L-methionine = 16-methoxytabersonine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 20992

(2Z,4E)-2-aminomuconate + H2O = (3E)-2-oxohex-3-enedioate + NH4(+)

Direction not assertedBalancedRhea 20996

1,2,3,5-tetrahydroxybenzene + 1,2,3-trihydroxybenzene = 1,2,3,5-tetrahydroxybenzene + 1,3,5-trihydroxybenzene

Direction not assertedBalancedRhea 21000

(R)-pantolactone + A = 2-dehydropantolactone + AH2

Direction not assertedBalancedRhea 21004

diethyl (2R,3R)-2-methyl-3-hydroxysuccinate + NADP(+) = diethyl 2-methyl-3-oxosuccinate + NADPH + H(+)

Direction not assertedBalancedRhea 21008

4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine = 4-O-([2-N-acetyl-alpha-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP + n H(+)

Direction not assertedBalance undeterminableRhea 21012

L-asparagine + H2O = L-aspartate + NH4(+)

Left to rightBalancedRhea 21016

5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate

Direction not assertedBalancedRhea 21020

glyoxylate + NADP(+) + CoA = oxalyl-CoA + NADPH + H(+)

Direction not assertedBalancedRhea 21024

an N-terminal L-alpha-aminoacyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-alpha-aminoacyl-[protein] + CoA + H(+)

Direction not assertedBalance undeterminableRhea 21028

glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)

Left to rightBalance undeterminableRhea 21032

2 acetyl-CoA = acetoacetyl-CoA + CoA

ReversibleBalancedRhea 21036

CO + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O = 2 reduced [2Fe-2S]-[ferredoxin] + CO2 + 2 H(+)

Direction not assertedBalance undeterminableRhea 21040

24-methylidenelophenol + S-adenosyl-L-methionine = (Z)-24-ethylidenelophenol + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 21044

isopropylamine + L-glutamate + ATP = gamma-L-glutamyl-isopropylamide + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 21048

(S)-2-hydroxypropyl-coenzyme M + NAD(+) = 2-oxopropyl-coenzyme M + NADH + H(+)

Direction not assertedBalancedRhea 21052

3,4-dichloroaniline + malonyl-CoA = N-(3,4-dichlorophenyl)malonamate + CoA

Direction not assertedBalancedRhea 21060

[protein]-disulfide + 2 glutathione = [protein]-dithiol + glutathione disulfide

ReversibleBalance undeterminableRhea 21064

nitrite + A + H2O = nitrate + AH2

Direction not assertedBalancedRhea 21068

2'-deoxyuridine + 2-oxoglutarate + O2 = uridine + succinate + CO2

Direction not assertedBalancedRhea 21076

L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate

Direction not assertedBalancedRhea 21080

chondroitin 4'-sulfate = dermatan 4'-sulfate

Direction not assertedBalance undeterminableRhea 21084

a (2R,3R)-dihydroflavonol + 2-oxoglutarate + O2 = a flavonol + succinate + CO2 + H2O

Direction not assertedBalance undeterminableRhea 21088

12-hydroxydihydrochelirubine + S-adenosyl-L-methionine = dihydromacarpine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 21092

3-dehydroquinate = 3-dehydroshikimate + H2O

Direction not assertedBalancedRhea 21096

cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O

Left to rightBalancedRhea 21104

(S)-3-methyl-2-oxopentanoate + H(+) = 2-methylbutanal + CO2

Direction not assertedBalancedRhea 21108

a globoside Gb3Cer (d18:1(4E)) + H2O = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + D-galactose

Left to rightBalance undeterminableRhea 21112

D-maltose + phosphate = beta-D-glucose 1-phosphate + D-glucose

Direction not assertedBalancedRhea 21116

cytidine(72) in tRNA(Thr) + S-adenosyl-L-methionine = 5-methylcytidine(72) in tRNA(Thr) + S-adenosyl-L-homocysteine + H(+)

Left to rightBalancedRhea 21124

zymosterol + S-adenosyl-L-methionine = fecosterol + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 21128

xanthine + O2 + H2O = urate + H2O2

Direction not assertedBalancedRhea 21132

(R)-carnitine + acetyl-CoA = O-acetyl-(R)-carnitine + CoA

Left to rightBalancedRhea 21136

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