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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Reactions
Reach

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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

25,951–26,000 of 31,435, by identifier

N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-D-glucose + H2O = lactose + N-acetylneuraminate
Left to rightBalancedRhea 64640
butan-1-ol + propanoyl-CoA = butyl propanoate + CoA
Direction not assertedBalancedRhea 64644
(E)-coniferaldehyde + NADP(+) + CoA = (E)-feruloyl-CoA + NADPH + H(+)
Direction not assertedBalancedRhea 64648
(E)-4-coumaraldehyde + NADP(+) + CoA = (E)-4-coumaroyl-CoA + NADPH + H(+)
Direction not assertedBalancedRhea 64652
(E)-sinapaldehyde + NADP(+) + CoA = (E)-sinapoyl-CoA + NADPH + H(+)
Direction not assertedBalancedRhea 64656
holo-[(phenol)carboxyphthiodiolenone synthase] + a long-chain fatty acid + ATP = a long-chain fatty acyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate
Direction not assertedBalance undeterminableRhea 64660

a long-chain fatty acyl-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] = a long-chain fatty acyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)

Direction not assertedBalance undeterminableRhea 64664

(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate

Left to rightBalancedRhea 64668

2-(methylsulfanyl)acetyl-CoA + butan-1-ol = butyl 2-(methylsulfanyl)acetate + CoA

Direction not assertedBalancedRhea 64672

3-(methylsulfanyl)propanoyl-CoA + butan-1-ol = butyl 3-(methylsulfanyl)propanoate + CoA

Direction not assertedBalancedRhea 64676

ethanol + benzoyl-CoA = ethyl benzoate + CoA

Direction not assertedBalancedRhea 64680

L-threonyl-[protein] + UDP-alpha-D-glucose = 3-O-(alpha-D-glucosyl)-L-threonyl-[protein] + UDP + H(+)

Direction not assertedBalance undeterminableRhea 64684

L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-alpha-D-glucosaminyl)-L-threonyl-[protein] + UDP + H(+)

Direction not assertedBalance undeterminableRhea 64688

isobutanol + NAD(+) = 2-methylpropanal + NADH + H(+)

Direction not assertedBalancedRhea 64692

benzyl alcohol + NAD(+) = benzaldehyde + NADH + H(+)

Direction not assertedBalancedRhea 64696

1-phenylethanol + NAD(+) = acetophenone + NADH + H(+)

Direction not assertedBalancedRhea 64700

diphenylmethanol + NAD(+) = benzophenone + NADH + H(+)

Direction not assertedBalancedRhea 64704

butan-1-ol + NADP(+) = butanal + NADPH + H(+)

Direction not assertedBalancedRhea 64708

1-propanol + NADP(+) = propanal + NADPH + H(+)

Direction not assertedBalancedRhea 64712

propanal + NADP(+) = acrolein + NADPH + H(+)

Direction not assertedBalancedRhea 64716

pyruvate(out) + H(+)(out) = pyruvate(in) + H(+)(in)

ReversibleBalancedTransportRhea 64720

(7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (7S,14S)-dihydroperoxy-(4Z,8E,10Z,12E,16Z,19Z)-docosahexaenoate

Left to rightBalancedRhea 64724

(7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (7S,17S)-dihydroperoxy-(4Z,8E,10Z,13Z,15E,19Z)-docosahexaenoate

Left to rightBalancedRhea 64728

(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (11S)-hydroperoxy-(4Z,7Z,9E,13Z,16Z,19Z)-docosahexaenoate

Left to rightBalancedRhea 64732

4-hydroxynonanal + NADP(+) = (E)-4-hydroxynon-2-enal + NADPH + H(+)

Right to leftBalancedRhea 64736

S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine + H2O = 3-methyl-3-sulfanylhexan-1-ol + pyruvate + NH4(+)

Direction not assertedBalancedRhea 64740

S-3-(hexan-1-ol)-L-cysteine + H2O = 3-sulfanyl-1-hexanol + pyruvate + NH4(+)

Direction not assertedBalancedRhea 64744

S-(4-hydroxy-3-methylbutan-2-yl)-L-cysteine + H2O = 2-methyl-3-sulfanylbutan-1-ol + pyruvate + NH4(+)

Direction not assertedBalancedRhea 64748

3-sulfanylpentan-1-ol-L-cysteine + H2O = 3-sulfanyl-1-pentanol + pyruvate + NH4(+)

Direction not assertedBalancedRhea 64752

S-benzyl-L-cysteine + H2O = benzylthiol + pyruvate + NH4(+)

Direction not assertedBalancedRhea 64756

S-ethyl-L-cysteine + H2O = ethanethiol + pyruvate + NH4(+)

Direction not assertedBalancedRhea 64760

S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine = 3-methyl-3-sulfanylhexan-1-ol + 2-aminoprop-2-enoate

Direction not assertedBalancedRhea 64764

S-3-(hexan-1-ol)-L-cysteine = 3-sulfanyl-1-hexanol + 2-aminoprop-2-enoate

Direction not assertedBalancedRhea 64768

S-(4-hydroxy-3-methylbutan-2-yl)-L-cysteine = 2-methyl-3-sulfanylbutan-1-ol + 2-aminoprop-2-enoate

Direction not assertedBalancedRhea 64772

3-sulfanylpentan-1-ol-L-cysteine = 3-sulfanyl-1-pentanol + 2-aminoprop-2-enoate

Direction not assertedBalancedRhea 64776

S-benzyl-L-cysteine = benzylthiol + 2-aminoprop-2-enoate

Direction not assertedBalancedRhea 64780

S-ethyl-L-cysteine = ethanethiol + 2-aminoprop-2-enoate

Direction not assertedBalancedRhea 64784

(E)-cinnamate + ATP + CoA = (E)-cinnamoyl-CoA + AMP + diphosphate

Direction not assertedBalancedRhea 64788

L-lysine + NADP(+) = L-1-piperideine-6-carboxylate + NH4(+) + NADPH + 2 H(+)

Direction not assertedBalancedRhea 64792

L-lysine + NADP(+) + H2O = (S)-2-amino-6-oxohexanoate + NH4(+) + NADPH + H(+)

Direction not assertedBalancedRhea 64796

S-(2-aminoethyl)-L-cysteine + NAD(+) = (4S)-5,6-dihydro-4H-1,3-thiazine-4-carboxylate + NH4(+) + NADH + 2 H(+)

Direction not assertedBalancedRhea 64800

S-(2-aminoethyl)-L-cysteine + acetyl-CoA = S-(2-acetamidoethyl)-L-cysteine + CoA + H(+)

Left to rightBalancedRhea 64804

O-(2-aminoethyl)-L-serine + acetyl-CoA = O-(2-acetamidoethyl)-L-serine + CoA + H(+)

Direction not assertedBalancedRhea 64808

S-(2-aminoethyl)-homocysteine + acetyl-CoA = S-(2-acetamidoethyl)-homocysteine + CoA + H(+)

Direction not assertedBalancedRhea 64812

5-aminolevulinate(in) = 5-aminolevulinate(out)

Direction not assertedBalancedTransportRhea 64816

2-phenylacetamide + H2O = 2-phenylacetate + NH4(+)

Direction not assertedBalancedRhea 64820

1-naphthaleneacetamide + H2O = 1-naphthaleneacetate + NH4(+)

Direction not assertedBalancedRhea 64824

3-hydroxybenzyl alcohol + acetyl-CoA = 3-hydroxy-benzyl acetate + CoA

Direction not assertedBalancedRhea 64828

3-hydroxybenzyl alcohol + benzoyl-CoA = 3-hydroxy-benzyl benzoate + CoA

Direction not assertedBalancedRhea 64832

2-phenylethanol + acetyl-CoA = phenethyl acetate + CoA

Direction not assertedBalancedRhea 64836

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