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ReactionsRhea and Human-GEM, by subsystem
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Reference

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

25,901–25,950 of 31,435, by identifier

glycylglycyl-L-isoleucine(out) + H(+)(out) = glycylglycyl-L-isoleucine(in) + H(+)(in)
Left to rightBalancedTransportRhea 64436
glycylglycyl-L-proline(out) + H(+)(out) = glycylglycyl-L-proline(in) + H(+)(in)
Left to rightBalancedTransportRhea 64440
L-lysyl(9)-[histone H3] + 2 S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 S-adenosyl-L-homocysteine + 2 H(+)
Left to rightBalance undeterminableRhea 64444
L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-homocysteine + 2 H(+)
Direction not assertedBalance undeterminableRhea 64448
L-lysyl(27)-[histone H3] + 2 S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + 2 S-adenosyl-L-homocysteine + 2 H(+)
Direction not assertedBalance undeterminableRhea 64452
L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-homocysteine + 3 H(+)
Direction not asserted

?

Balance undeterminable

Rhea 64456

acetyl phosphate + L-lysyl-[protein] = N(6)-acetyl-L-lysyl-[protein] + phosphate + H(+)

Direction not assertedBalance undeterminableRhea 64460

L-tyrosyl-[protein] + 2 O2 = L-topaquinyl-[protein] + H2O2 + H(+)

Direction not assertedBalance undeterminableRhea 64464

(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NADP(+) = 4-methylsulfanyl-2-oxobutanoate + NADPH + H(+)

Direction not assertedBalancedRhea 64468

(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + S-adenosyl-L-methionine = (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 64472

4-[(2E,7S,8E,10E,13R,14R,16E,18E)-14-ethyl-7,13-dihydroxy-2,16,18-trimethylicosa-2,8,10,16,18-pentaenoyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate = 4-[(1R,2R,4aS,5S,8aR)-2-[(2R,3R,5E,7E)-3-ethyl-2-hydroxy-5,7-dimethylnona-5,7-dien-1-yl]-5-hydroxy-1-methyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate

Direction not assertedBalancedRhea 64476

4-[(1R,2R,4aS,5S,8aR)-2-[(2R,3R,5E,7E)-3-ethyl-2-hydroxy-5,7-dimethylnona-5,7-dien-1-yl]-5-hydroxy-1-methyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate = (1S,3R,6R,8R,9R,11R,14S,15S,19R,20R)-8-ethyl-9,15-dihydroxy-3,4,6,20-tetramethyl-21,23-dioxo-24-azapentacyclo[20.2.1.0(1,6).0(11,20).0(14,19)]pentacosa-4,12,22(25)-trien-25-olate

Direction not assertedBalancedRhea 64480

holo-[ACP] + 6 malonyl-CoA + acetyl-CoA + 6 H(+) = 3,5,7,9,11,13-hexaoxotetradecanoyl-[ACP] + 6 CO2 + 7 CoA

Direction not assertedBalance undeterminableRhea 64484

holo-[ACP] + 5 malonyl-CoA + acetyl-CoA + 5 H(+) = 3,5,7,9,11-pentaoxododecanoyl-[ACP] + 5 CO2 + 6 CoA

Direction not assertedBalance undeterminableRhea 64488

3,5,7,9,11,13-hexaoxotetradecanoyl-[ACP] = dehydrocitreoisocoumarin + holo-[ACP] + H2O

Direction not assertedBalance undeterminableRhea 64492

3,5,7,9,11-pentaoxododecanoyl-[ACP] = 6,8-dihydroxy-3-(2-oxopropyl)-isocoumarin + holo-[ACP] + H2O

Direction not assertedBalance undeterminableRhea 64496

3 malonyl-CoA + acetyl-CoA + S-adenosyl-L-methionine + H(+) = 3-methylorsellinate + S-adenosyl-L-homocysteine + 3 CO2 + 4 CoA

Direction not assertedBalancedRhea 64500

propanoyl-CoA + 3 malonyl-CoA + AH2 + 2 S-adenosyl-L-methionine + H(+) = 2-ethyl-4,6-dihydroxy-3,5-dimethylbenzaldehyde + A + 2 S-adenosyl-L-homocysteine + 3 CO2 + 4 CoA + H2O

Direction not assertedBalancedRhea 64504

4 malonyl-CoA + acetyl-CoA + AH2 + S-adenosyl-L-methionine + 3 H(+) = 2,4-dihydroxy-3-methyl-6-(2-oxopropyl)benzaldehyde + A + S-adenosyl-L-homocysteine + 4 CO2 + 5 CoA + H2O

Direction not assertedBalancedRhea 64508

(3E,5E,7S)-5,7-dimethyl-2-oxonona-3,5-dienyl-[ACP] + 4 malonyl-CoA + AH2 + S-adenosyl-L-methionine + 3 H(+) = 6-[(3E,5E,7S)-5,7-dimethyl-2-oxonona-3,5-dienyl]-2,4-dihydroxy-3-methylbenzaldehyde + holo-[ACP] + A + S-adenosyl-L-homocysteine + 4 CO2 + 4 CoA + H2O

Direction not assertedBalance undeterminableRhea 64512

2-hydroxyethane-1-sulfonate + NAD(+) = sulfoacetaldehyde + NADH + H(+)

Direction not assertedBalancedRhea 64516

3 malonyl-CoA + acetyl-CoA + AH2 + 3 H(+) = orsellinaldehyde + A + 3 CO2 + 4 CoA + H2O

Direction not assertedBalancedRhea 64520

(2E,4E,6E)-octa-2,4,6-trienyl-[ACP] + 4 malonyl-CoA + AH2 + 3 H(+) = 2,4-dihydroxy-6-[(3E,5E,7E)-2-oxonona-3,5,7-trienyl]benzaldehyde + holo-[ACP] + A + 4 CO2 + 4 CoA + H2O

Direction not assertedBalance undeterminableRhea 64524

decanoyl-[ACP] + 4 malonyl-CoA + AH2 + S-adenosyl-L-methionine + 3 H(+) = 2,4-dihydroxy-3-methyl-6-(2-oxoundecyl)benzaldehyde + holo-[ACP] + A + S-adenosyl-L-homocysteine + 4 CO2 + 4 CoA + H2O

Direction not assertedBalance undeterminableRhea 64528

an N-(1,2 saturated very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = an N-(2R-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + 2 Fe(III)-[cytochrome b5] + H2O

Direction not assertedBalance undeterminableRhea 64532

an N-(2R-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) = a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + a 1,2-diacyl-sn-glycerol

Direction not assertedBalance undeterminableRhea 64536

an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) = an alpha-D-mannosyl-6-(1D-myo-inositol phospho)-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + a 1,2-diacyl-sn-glycerol

Direction not assertedBalance undeterminableRhea 64540

L-tyrosine + holo-[ACP] + 7 malonyl-CoA + acetyl-CoA + 8 AH2 + 2 S-adenosyl-L-methionine + ATP + 4 H(+) = N-[(4E,6E,10S,12Z,14E)-6,10-dimethyl-3-oxohexadeca-4,6,12,14-tetraenoyl]-L-tyrosyl-[ACP] + 8 A + AMP + 2 S-adenosyl-L-homocysteine + 7 CO2 + diphosphate + 8 CoA + 6 H2O

Direction not assertedBalance undeterminableRhea 64544

N-[(4E,6E,10S,12Z,14E)-6,10-dimethyl-3-oxohexadeca-4,6,12,14-tetraenoyl]-L-tyrosyl-[ACP] = (3E,5S)-3-[(2E,4E,8S,10E,12Z)-1-hydroxy-4,8-dimethyltetradeca-2,4,10,12-tetraen-1-ylidene]-5-[(4-hydroxyphenyl)methyl]pyrrolidine-2,4-dione + holo-[ACP] + H(+)

Direction not assertedBalance undeterminableRhea 64548

(3E,5S)-3-[(2E,4E,8S,10E,12Z)-1-hydroxy-4,8-dimethyltetradeca-2,4,10,12-tetraen-1-ylidene]-5-[(4-hydroxyphenyl)methyl]pyrrolidine-2,4-dione + reduced [NADPH--hemoprotein reductase] + O2 = 3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one + oxidized [NADPH--hemoprotein reductase] + 2 H2O

Direction not assertedBalance undeterminableRhea 64552

3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one = 8-epi-ilicicolin H

Direction not assertedBalancedRhea 64556

butan-2-ol + NAD(+) = butan-2-one + NADH + H(+)

Direction not assertedBalancedRhea 64560

8-epi-ilicicolin H = ilicicolin H

Direction not assertedBalancedRhea 64564

3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one = ilicicolin H

Direction not assertedBalancedRhea 64568

neryl diphosphate + isopentenyl diphosphate = (2Z,6Z)-farnesyl diphosphate + diphosphate

Direction not assertedBalancedRhea 64572

2 Fe(III)-[cytochrome b5] + NADPH = 2 Fe(II)-[cytochrome b5] + NADP(+) + H(+)

Direction not assertedBalance undeterminableRhea 64576

(2Z,6Z)-farnesyl diphosphate + isopentenyl diphosphate = nerylneryl diphosphate + diphosphate

Direction not assertedBalancedRhea 64580

2-hydroxyethane-1-sulfonate(out) + Na(+)(out) = 2-hydroxyethane-1-sulfonate(in) + Na(+)(in)

Direction not assertedBalancedTransportRhea 64584

an N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) = an inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-4R-hydroxysphingoid base + a 1,2-diacyl-sn-glycerol

Direction not assertedBalance undeterminableRhea 64592

a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP-alpha-D-mannose = an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP + H(+)

Direction not assertedBalance undeterminableRhea 64596

an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) = an alpha-D-mannosyl-6-(1D-myo-inositol phospho)-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + a 1,2-diacyl-sn-glycerol

Direction not assertedBalance undeterminableRhea 64600

L-seryl-[protein] + UTP = O-(5'-uridylyl)-L-seryl-[protein] + diphosphate

Direction not assertedBalance undeterminableRhea 64604

L-threonyl-[protein] + UTP = uridylyl-L-threonyl-[protein] + diphosphate

Direction not assertedBalance undeterminableRhea 64608

tRNA(Gln) + L-glutamate + ATP = L-glutamyl-tRNA(Gln) + AMP + diphosphate

Left to rightBalancedRhea 64612

(E)-coniferol + acetyl-CoA = (E)-coniferyl acetate + CoA

Direction not assertedBalancedRhea 64616

(E)-sinapyl alcohol + acetyl-CoA = (E)-sinapoyl actetate + CoA

Direction not assertedBalancedRhea 64620

(2E)-geraniol + acetyl-CoA = (2E)-geranyl acetate + CoA

Direction not assertedBalancedRhea 64624

octan-1-ol + acetyl-CoA = octyl acetate + CoA

Direction not assertedBalancedRhea 64628

butan-1-ol + acetyl-CoA = butyl acetate + CoA

Direction not assertedBalancedRhea 64632

butan-1-ol + benzoyl-CoA = butyl benzoate + CoA

Direction not assertedBalancedRhea 64636

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