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CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
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AssessmentsRegulatory determinations, transcribed
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Reference

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

24,901–24,950 of 31,435, by identifier

D-glucose(out) = D-glucose(in)
Direction not assertedBalancedTransportRhea 60376
L-dehydroascorbate(out) = L-dehydroascorbate(in)
Direction not assertedBalancedTransportRhea 60380
enterobactin + H2O = N-(2,3-dihydroxybenzoyl)-L-serine trimer
Direction not assertedBalancedRhea 60384
Fe(III)-di(C-5-deoxy-beta-D-glucosyl)-enterobactin + H2O = Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+)
Direction not assertedBalancedRhea 60388
Fe(III)-C-5-deoxy-beta-D-glucosyl-enterobactin + H2O = Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H(+)
Direction not assertedBalancedRhea 60392
Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H2O + H(+) = Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine

? Direction not asserted

Balanced

Rhea 60396

Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H2O + H(+) = Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine

Direction not assertedBalancedRhea 60400

Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H2O + H(+) = Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + N-(2,3-dihydroxybenzoyl)-L-serine

Direction not assertedBalancedRhea 60404

Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 + H2O + H(+) = Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine] + N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine

Direction not assertedBalancedRhea 60408

monoglucosyl-enterobactin + H2O = [N-(2,3-dihydroxybenzoyl)-L-seryl]2-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine + H(+)

Direction not assertedBalancedRhea 60412

diglucosyl-enterobactin + H2O = N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 + H(+)

Direction not assertedBalancedRhea 60416

triglucosyl-enterobactin + H2O = [N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]3 + H(+)

Direction not assertedBalancedRhea 60420

(2E,6E)-farnesyl diphosphate + H2O = valerianol + diphosphate

Direction not assertedBalancedRhea 60424

(indol-3-yl)acetyl-L-aspartate + H2O = (indol-3-yl)acetate + L-aspartate

Direction not assertedBalancedRhea 60428

cannabigerolate + A = cannabichromenate + AH2

Direction not assertedBalancedRhea 60432

3-methylbutyl acetate + H2O = 3-methylbutan-1-ol + acetate + H(+)

Direction not assertedBalancedRhea 60436

methyl acetate + H2O = methanol + acetate + H(+)

Direction not assertedBalancedRhea 60440

an S-substituted L-cysteinylglycine + H2O = an S-substituted L-cysteine + glycine

Left to rightBalance undeterminableRhea 60444

an S-substituted glutathione + H2O = S-substituted gamma-glutamyl-L-cysteine + glycine

Direction not assertedBalance undeterminableRhea 60448

2-hydroxyethane-1-sulfonate = acetaldehyde + sulfite + H(+)

Direction not assertedBalancedRhea 60452

UTP + ATP = 3',3'-cUAMP + 2 diphosphate

Direction not assertedBalancedRhea 60456

5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) + (6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out) + (6S)-5-methyl-5,6,7,8-tetrahydrofolate(in)

Left to rightBalancedTransportRhea 60460

2',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) = 2',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)

Left to rightBalancedTransportRhea 60464

3',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) = 3',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)

Left to rightBalancedTransportRhea 60468

(6S)-5-formyl-5,6,7,8-tetrahydrofolate(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) = (6S)-5-formyl-5,6,7,8-tetrahydrofolate(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)

Direction not assertedBalancedTransportRhea 60472

GTP + 2 ATP = 3',3',3'-cAAG + 3 diphosphate

Direction not assertedBalancedRhea 60476

2 UTP = c-di-UMP + 2 diphosphate

Direction not assertedBalancedRhea 60480

UTP + CTP = cyclic CMP-UMP + 2 diphosphate

Direction not assertedBalancedRhea 60484

a 2-acyl-6-(alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl)-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = a 2-acyl-6-[alpha-D-mannosyl-(1->6)-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol + a di-trans,poly-cis-dolichyl phosphate + H(+)

Left to rightBalance undeterminableRhea 60488

a 2-acyl-6-alpha-D-glucosaminyl-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + a 1-radyl-2-acyl-sn-glycerolipid = a 2-acyl-6-alpha-D-glucosaminyl-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol + a 1,2-diacyl-sn-glycerolipid

Direction not assertedBalance undeterminableRhea 60492

a 6-(alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + a fatty acyl-CoA = a 2-acyl-6-alpha-D-glucosaminyl-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + CoA

Left to rightBalance undeterminableRhea 60496

a 2-acyl-6-alpha-D-glucosaminyl-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = a 2-acyl-6-(alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl)-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol + a di-trans,poly-cis-dolichyl phosphate + H(+)

Left to rightBalance undeterminableRhea 60500

a CDP-1,2-diacyl-sn-glycerol + 1D-myo-inositol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)

Direction not assertedBalance undeterminableRhea 60504

a guanosine in mRNA + S-adenosyl-L-methionine = an N(7)-methylguanosine in mRNA + S-adenosyl-L-homocysteine

Left to rightBalance undeterminableRhea 60508

a guanosine in miRNA + S-adenosyl-L-methionine = an N(7)-methylguanosine in miRNA + S-adenosyl-L-homocysteine

Left to rightBalance undeterminableRhea 60512

L-tryptophan = D-tryptophan

Direction not assertedBalancedRhea 60516

L-cystine-bis-glycine + 2 H2O = L-cystine + 2 glycine

Direction not assertedBalancedRhea 60520

5-hydroxyuridine(34) in tRNA + S-adenosyl-L-methionine = 5-methoxyuridine(34) in tRNA + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 60524

a 2-acyl-6-[6-phosphoethanolamine-alpha-D-mannosyl-(1->2)-6-phosphoethanolamine-alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol + [protein]-C-terminal L-amino acid = [protein]-C-terminal carboxyl phosphoethanolamide-GPI(H8) + H2O

Left to rightBalance undeterminableRhea 60544

uridine(35) in tRNA(Tyr) = pseudouridine(35) in tRNA(Tyr)

Direction not assertedBalancedRhea 60556

L-methionyl-[protein] + S-adenosyl-L-methionine = S-methyl-L-methionyl-[protein] + S-adenosyl-L-homocysteine

Direction not assertedBalance undeterminableRhea 60560

2-deoxy-D-glucose + ATP = 2-deoxy-D-glucose 6-phosphate + ADP + H(+)

Direction not assertedBalancedRhea 60564

N-acetyl-L-tryptophan = N-acetyl-D-tryptophan

Direction not assertedBalancedRhea 60568

(2E)-glutaconyl-CoA + H(+) = (2E)-butenoyl-CoA + CO2

Direction not assertedBalancedRhea 60572

methyl-Co(III)-[tetramethylammonium-specific corrinoid protein] + coenzyme M = Co(I)-[tetramethylammonium-specific corrinoid protein] + methyl-coenzyme M + H(+)

Direction not assertedBalance undeterminableRhea 60576

(9Z,12Z)-octadecadienoate + reduced [NADPH--hemoprotein reductase] + O2 = 18-hydroxy-(9Z,12Z)-octadecadienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 60580

1-tetradecanoyl-sn-glycero-3-phosphocholine = 1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + choline

Direction not assertedBalancedRhea 60604

1-tetradecanoyl-sn-glycero-3-phosphoethanolamine = 1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + ethanolamine

Direction not assertedBalancedRhea 60608

1-octanoyl-sn-glycero-3-phosphocholine = 1-octanoyl-sn-glycero-2,3-cyclic phosphate + choline

Direction not assertedBalancedRhea 60612

N-dodecanoyl-heptadecasphing-4-enine-1-phosphoethanolamine = N-dodecanoyl-heptadecasphing-4-enine-1,3-cyclic phosphate + ethanolamine

Direction not assertedBalancedRhea 60616

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