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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
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Reactions
Reach

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Organisms
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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

24,801–24,850 of 31,435, by identifier

2-phenylacetate + H(+) = toluene + CO2
Direction not assertedBalancedRhea 59976
8-oxo-dGTP + H2O = 8-oxo-dGDP + phosphate + H(+)
Left to rightBalancedRhea 59980
an N(2)-acyl-L-glutamine + H2O = a carboxylate + L-glutamine
Direction not assertedBalance undeterminableRhea 59984
cyclohexane-1-carbonyl-CoA + NADP(+) = cyclohex-1-ene-1-carbonyl-CoA + NADPH + H(+)
Direction not assertedBalancedRhea 59988
phloretate + oxidized [electron-transfer flavoprotein] + H(+) = (E)-4-coumarate + reduced [electron-transfer flavoprotein]
Direction not assertedBalance undeterminableRhea 59992
3-phenylpropanoate + oxidized [electron-transfer flavoprotein] + H(+) = (E)-cinnamate + reduced [electron-transfer flavoprotein]
Direction not assertedBalance undeterminableRhea 59996
hydroxymethylphosphonate + O2 = formate + phosphate + 2 H(+)

Direction not assertedBalancedRhea 60000

(L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + H2O = (L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + L-glutamate

Left to rightBalance undeterminableRhea 60004

a tRNA precursor + 2 CTP = a tRNA with a 3' CC end + 2 diphosphate

Direction not assertedBalance undeterminableRhea 60008

a tRNA with a 3' CC end + ATP = a tRNA with a 3' CCA end + diphosphate

Direction not assertedBalance undeterminableRhea 60012

(2E,6E)-farnesyl diphosphate = sesquisabinene B + diphosphate

Direction not assertedBalancedRhea 60016

(2E,6E)-farnesyl diphosphate = sesquisabinene A + diphosphate

Direction not assertedBalancedRhea 60020

(R,R)-chrysanthemyl diphosphate + H2O = (R,R)-chrysanthemol + diphosphate

Direction not assertedBalancedRhea 60024

(2E)-geranyl diphosphate + H2O = 4-terpineol + diphosphate

Direction not assertedBalancedRhea 60028

8-oxo-GTP + H2O = 8-oxo-GDP + phosphate + H(+)

Direction not assertedBalancedRhea 60032

N(2)-(3-hydroxy-3-methylhexanoyl)-L-glutaminate + H2O = 3-hydroxy-3-methylhexanoate + L-glutamine

Direction not assertedBalancedRhea 60036

N(2)-[(2E)-3-methylhex-2-enoyl]-L-glutaminate + H2O = (2E)-3-methylhex-2-enoate + L-glutamine

Direction not assertedBalancedRhea 60040

a beta-D-Gal-(1<->1')-ceramide + UDP-alpha-D-galactose = alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer + UDP + H(+)

Left to rightBalance undeterminableRhea 60044

a 3beta-hydroxy-4,4-dimethylsteroid + 3 NADH + 3 O2 + 2 H(+) = a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + 3 NAD(+) + 4 H2O

Direction not assertedBalance undeterminableRhea 60048

a 3beta-hydroxy-4,4-dimethylsteroid + NADH + O2 + H(+) = a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + NAD(+) + H2O

Direction not assertedBalance undeterminableRhea 60052

a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + NADH + O2 + H(+) = a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + NAD(+) + 2 H2O

Direction not assertedBalance undeterminableRhea 60056

a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose = alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer(d18:1(4E)) + UDP + H(+)

Direction not assertedBalance undeterminableRhea 60060

a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + NADH + O2 = a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NAD(+) + H2O

Direction not assertedBalance undeterminableRhea 60064

4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 3 NADH + 3 O2 + 2 H(+) = 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 3 NAD(+) + 4 H2O

Direction not assertedBalancedRhea 60068

4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADH + O2 + H(+) = 4beta-hydroxymethyl-4alpha-methylzymosterol + NAD(+) + H2O

Direction not assertedBalancedRhea 60072

4beta-hydroxymethyl-4alpha-methylzymosterol + NADH + O2 + H(+) = 4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NAD(+) + 2 H2O

Direction not assertedBalancedRhea 60076

4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADH + O2 = 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NAD(+) + H2O

Direction not assertedBalancedRhea 60080

a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NAD(+) = a 4alpha-methyl-3-oxosteroid + CO2 + NADH

Direction not assertedBalance undeterminableRhea 60084

a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NADP(+) = a 4alpha-methyl-3-oxosteroid + CO2 + NADPH

Direction not assertedBalance undeterminableRhea 60088

4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NAD(+) = 3-dehydro-4alpha-methylzymosterol + CO2 + NADH

Direction not assertedBalancedRhea 60092

4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) = 3-dehydro-4alpha-methylzymosterol + CO2 + NADPH

Direction not assertedBalancedRhea 60096

cyanidin + UDP-alpha-D-glucose = cyanidin 3-O-beta-D-glucoside + UDP + H(+)

Direction not assertedBalancedRhea 60100

indole-3-propanoate + oxidized [electron-transfer flavoprotein] + H(+) = (E)-3-(indol-3-yl)acrylate + reduced [electron-transfer flavoprotein]

Direction not assertedBalance undeterminableRhea 60104

(R)-3-(4-hydroxyphenyl)lactoyl-CoA = (E)-4-coumaroyl-CoA + H2O

Direction not assertedBalancedRhea 60108

(R)-3-(indol-3-yl)lactoyl-CoA = (E)-3-(indol-3-yl)acryloyl-CoA + H2O

Direction not assertedBalancedRhea 60112

methylphosphonate + 2-oxoglutarate + O2 = hydroxymethylphosphonate + succinate + CO2

Direction not assertedBalancedRhea 60116

(2E,6E)-farnesyl diphosphate + S-adenosyl-L-methionine = pre-sodorifen diphosphate + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 60120

pre-sodorifen diphosphate = sodorifen + diphosphate

Direction not assertedBalancedRhea 60124

17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + phosphate + H(+)

Left to rightBalancedTransportRhea 60128

a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2 = a (8S,9S)-5-glyceryl-2'-deoxycytidine in DNA + glyoxylate + CO2

Direction not assertedBalance undeterminableRhea 60132

a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2 = a (8S,9R)-5-glyceryl-2'-deoxycytidine in DNA + glyoxylate + CO2

Direction not assertedBalance undeterminableRhea 60136

dodecanoyl-CoA + malonyl-CoA + H(+) = 3-oxotetradecanoyl-CoA + CO2 + CoA

Left to rightBalancedRhea 60140

L-glutamyl-[protein] + L-glutamate + ATP = gamma-L-glutamyl-L-glutamyl-[protein] + ADP + phosphate + H(+)

Left to rightBalance undeterminableRhea 60144

(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + L-glutamate + ATP = (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + ADP + phosphate + H(+)

Left to rightBalance undeterminableRhea 60148

gamma-L-glutamyl-L-glutamyl-[protein] + H2O = L-glutamyl-[protein] + L-glutamate

Left to rightBalance undeterminableRhea 60152

D-galactose(out) + ATP + H2O = D-galactose(in) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 60156

vincristine(in) + ATP + H2O = vincristine(out) + ADP + phosphate + H(+)

Left to rightBalancedTransportRhea 60160

a guanosine in RNA + S-adenosyl-L-methionine = an N(7)-methylguanosine in RNA + S-adenosyl-L-homocysteine

Direction not assertedBalance undeterminableRhea 60164

a fatty acid + ATP = a fatty acyl phosphate + ADP

Direction not assertedBalance undeterminableRhea 60168

5-methylaminomethyl-S-(2E)-geranyl-thiouridine(34) in tRNA + selenophosphate + H(+) = 5-methylaminomethyl-2-(Se-phospho)selenouridine(34) in tRNA + (2E)-thiogeraniol

Direction not assertedBalancedRhea 60172

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