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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
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Reactions
Reach

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Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

24,651–24,700 of 31,435, by identifier

4-amino-4-deoxychorismate = 4-amino-4-deoxyprephenate
Direction not assertedBalancedRhea 59376
4-amino-4-deoxyprephenate + NAD(+) = 3-(4-aminophenyl)pyruvate + CO2 + NADH + H(+)
Direction not assertedBalancedRhea 59380
4-amino-L-phenylalanine + 2-oxoglutarate = 3-(4-aminophenyl)pyruvate + L-glutamate
Direction not assertedBalancedRhea 59384
a fatty acid ester + H2O = an aliphatic alcohol + a fatty acid + H(+)
Direction not assertedBalance undeterminableRhea 59388
L-seryl-[protein] + acetyl-CoA = O-acetyl-L-seryl-[protein] + CoA
Left to rightBalance undeterminableRhea 59392
L-leucine = D-leucine
Direction not assertedBalancedRhea 59396
L-2-aminohexanoate = D-2-aminohexanoate

? Direction not asserted

Balanced

Rhea 59400

L-homoserine = D-homoserine

Direction not assertedBalancedRhea 59404

N-acetyl-L-aspartate + H2O = L-aspartate + acetate

Left to rightBalancedRhea 59408

2-oxosuccinamate + H2O = oxaloacetate + NH4(+)

Left to rightBalancedRhea 59412

tryptamine + O2 + H2O = indole-3-acetaldehyde + H2O2 + NH4(+)

Left to rightBalancedRhea 59416

methylamine + O2 + H2O = formaldehyde + H2O2 + NH4(+)

Left to rightBalancedRhea 59420

benzylamine + O2 + H2O = benzaldehyde + H2O2 + NH4(+)

Left to rightBalancedRhea 59424

3-hydroxypropanal + NADP(+) + H2O = 3-hydroxypropanoate + NADPH + 2 H(+)

Direction not assertedBalancedRhea 59428

3-hydroxypropanal + NAD(+) + H2O = 3-hydroxypropanoate + NADH + 2 H(+)

Direction not assertedBalancedRhea 59432

4-amino-L-phenylalanine + holo-[peptidyl-carrier protein] + ATP = 4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AMP + diphosphate

Direction not assertedBalance undeterminableRhea 59436

(-)-dehydrodiconiferyl alcohol + NADPH + H(+) = (S)-isodihydrodehydrodiconiferyl alcohol + NADP(+)

Direction not assertedBalancedRhea 59440

1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene + A = 1,1'-dihydroxy-3,4-didehydro-1,2-dihydrolycopene + AH2

Direction not assertedBalancedRhea 59444

dodecan-1-ol + NADP(+) = dodecanal + NADPH + H(+)

Direction not assertedBalancedRhea 59448

a long-chain primary fatty alcohol + NADP(+) = a long-chain fatty aldehyde + NADPH + H(+)

Direction not assertedBalance undeterminableRhea 59452

tetradecan-1-ol + NADP(+) = tetradecanal + NADPH + H(+)

Direction not assertedBalancedRhea 59456

hexadecan-1-ol + NADP(+) = hexadecanal + NADPH + H(+)

Direction not assertedBalancedRhea 59460

octadecan-1-ol + NADP(+) = octadecanal + NADPH + H(+)

Direction not assertedBalancedRhea 59464

an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate

Left to rightBalance undeterminableRhea 59468

2',3'-cGAMP + H2O = Gp(2'-5')Ap(3') + H(+)

Direction not assertedBalancedRhea 59472

benzoate + L-phenylalanine + 2 AH2 + 2 ATP = N-benzoyl-L-phenylalaninol + 2 A + 2 AMP + 2 diphosphate + H(+)

Direction not assertedBalancedRhea 59476

schleiferon A + O2 = schleiferon B + H2O2 + H(+)

Direction not assertedBalancedRhea 59480

arsenite + 2 Fe(III)-[cytochrome c] + H2O = arsenate + 2 Fe(II)-[cytochrome c] + 3 H(+)

Direction not assertedBalance undeterminableRhea 59484

beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + ATP = beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + ADP

Direction not assertedBalancedRhea 59488

L-tryptophyl-[protein] + (2E)-geranyl diphosphate = (2S,3R)-3-geranyl-2,3-dihydro-2,N(alpha)-cyclo-L-tryptophyl-[protein] + diphosphate

Direction not assertedBalance undeterminableRhea 59492

(20S)-20-O-(beta-D-glucosyl)-3-hydroxydammarene + reduced [NADPH--hemoprotein reductase] + O2 = (20S)-ginsenoside C-K + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 59496

5-diphospho-1D-myo-inositol 1,3,4,6-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + phosphate + H(+)

Left to rightBalancedRhea 59500

glycyl-L-cysteinyl-[protein] + cholesterol + H(+) = [protein]-C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl-[protein]

Left to rightBalance undeterminableRhea 59504

L-cysteinyl-[protein] + fumarate = S-(2-succinyl)-L-cysteinyl-[protein]

Direction not assertedBalance undeterminableRhea 59508

acetylsalicylate + L-seryl-[protein] = O-acetyl-L-seryl-[protein] + salicylate

Direction not assertedBalance undeterminableRhea 59512

acetylsalicylate + L-lysyl-[protein] = N(6)-acetyl-L-lysyl-[protein] + salicylate + H(+)

Direction not assertedBalance undeterminableRhea 59516

butanoyl-CoA + hydrogencarbonate + ATP = (2S)-ethylmalonyl-CoA + ADP + phosphate + H(+)

Left to rightBalancedRhea 59520

9S,10-epoxy-(10,12Z)-octadecadienoate + L-aspartyl-[protein] + H(+) = 9-O-10-oxo-(12Z)-octadecenoate L-aspartatyl ester-[protein]

Direction not assertedBalance undeterminableRhea 59524

N-terminal L-cysteinyl-[protein] + hexadecanoyl-CoA = N-terminal N-hexadecanoyl-L-cysteinyl-[protein] + CoA + H(+)

Left to rightBalance undeterminableRhea 59528

(S)-reticuline + S-adenosyl-L-methionine = (S)-codamine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 59532

butanoyl-CoA + hydrogencarbonate + ATP = (2R)-ethylmalonyl-CoA + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 59536

(2R)-ethylmalonyl-CoA + H(+) = butanoyl-CoA + CO2

Left to rightBalancedRhea 59540

N,N'-diacetylchitobiose + O2 = N,N'-diacetylchitobiono-1,5-lactone + H2O2

Direction not assertedBalancedRhea 59544

N,N',N''-triacetylchitotriose + O2 = N,N',N''-triacetylchitotriono-1,5-lactone + H2O2

Direction not assertedBalancedRhea 59548

N,N',N'',N'''-tetraacetylchitotetraose + O2 = N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone + H2O2

Direction not assertedBalancedRhea 59552

N,N'-diacetylchitobiono-1,5-lactone + H2O = N,N'-diacetylchitobionate + H(+)

Direction not assertedBalancedRhea 59556

N,N',N''-triacetylchitotriono-1,5-lactone + H2O = N,N',N''-triacetylchitotrionate + H(+)

Direction not assertedBalancedRhea 59560

N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone + H2O = N,N',N'',N'''-tetraacetylchitotetraonate + H(+)

Direction not assertedBalancedRhea 59564

4-aminobutanoate + L-histidine + ATP = L-homocarnosine + ADP + phosphate + H(+)

Left to rightBalancedRhea 59568

L-homocarnosine + H2O = 4-aminobutanoate + L-histidine

Left to rightBalancedRhea 59572

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