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ProteinsTransporters and enzymes
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ReactionsRhea and Human-GEM, by subsystem
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Reference

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

21,401–21,450 of 31,435, by identifier

cholesterol + reduced [NADPH--hemoprotein reductase] + O2 = 4beta-hydroxycholesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Left to rightBalance undeterminableRhea 46128
cholesterol + NADPH + O2 + H(+) = 25-hydroxycholesterol + NADP(+) + H2O
Left to rightBalancedRhea 46132
aminopyrrolnitrin + NADPH + 2 O2 + H(+) = pyrrolnitrin + NADP(+) + 2 H2O
Direction not assertedBalancedRhea 46136
cholesterol + reduced [NADPH--hemoprotein reductase] + O2 = (22R)-hydroxycholesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Left to rightBalance undeterminableRhea 46140
cholesterol + reduced [NADPH--hemoprotein reductase] + O2 = (24R)-hydroxycholesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Left to rightBalance undeterminableRhea 46144
a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-deoxyribonucleoside + triphosphate + H(+)
Left to rightBalance undeterminableRhea

46148

a plastoquinone + 15-cis-phytoene = 15,9'-di-cis-phytofluene + a plastoquinol

Direction not assertedBalance undeterminableRhea 46152

15,9'-di-cis-phytofluene + a plastoquinone = 9,9',15-tri-cis-zeta-carotene + a plastoquinol

Direction not assertedBalance undeterminableRhea 46156

a quinone + NADH + H(+) = a quinol + NAD(+)

Left to rightBalance undeterminableRhea 46160

a quinone + NADPH + H(+) = a quinol + NADP(+)

Left to rightBalance undeterminableRhea 46164

pentanoate + ATP + CoA = pentanoyl-CoA + AMP + diphosphate

Direction not assertedBalancedRhea 46168

butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate

Left to rightBalancedRhea 46172

2-methylpropanoate + ATP + CoA = 2-methylpropanoyl-CoA + AMP + diphosphate

Left to rightBalancedRhea 46176

2-methylbutanoate + ATP + CoA = 2-methylbutanoyl-CoA + AMP + diphosphate

Left to rightBalancedRhea 46180

3-methylbutanoate + ATP + CoA = 3-methylbutanoyl-CoA + AMP + diphosphate

Direction not assertedBalancedRhea 46184

an aliphatic nitrile + 2 H2O = a carboxylate + NH4(+)

Direction not assertedBalance undeterminableRhea 46188

3beta-hydroxyandrost-5-en-17-one + reduced [NADPH--hemoprotein reductase] + O2 = 3beta,7alpha-dihydroxyandrost-5-en-17-one + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 46192

pregnenolone + reduced [NADPH--hemoprotein reductase] + O2 = 7alpha-hydroxypregnenolone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 46196

5alpha-androstane-3beta,17beta-diol + reduced [NADPH--hemoprotein reductase] + O2 = 5alpha-androstane-3beta,6alpha,17beta-triol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 46200

androst-5-en-3beta,17beta-diol + reduced [NADPH--hemoprotein reductase] + O2 = androst-5-en-3beta,7alpha,17beta-triol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 46204

eicosanoate + ATP + CoA = eicosanoyl-CoA + AMP + diphosphate

Left to rightBalancedRhea 46208

N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine + H2O = 4-amino-5-aminomethyl-2-methylpyrimidine + formate

Direction not assertedBalancedRhea 46212

progesterone + NADPH + H(+) = 3beta-hydroxypregn-4-ene-20-one + NADP(+)

Left to rightBalancedRhea 46216

androst-5-en-3beta,17beta-diol + NAD(+) = 3beta-hydroxyandrost-5-en-17-one + NADH + H(+)

Direction not assertedBalancedRhea 46220

(E)-feruloyl-CoA + H2O = (E)-ferulate + CoA + H(+)

Direction not assertedBalancedRhea 46224

apo-[peptidyl-carrier protein] + CoA = holo-[peptidyl-carrier protein] + adenosine 3',5'-bisphosphate + H(+)

Direction not assertedBalance undeterminableRhea 46228

(9Z,12Z)-hexadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z,12Z,15Z)-hexadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O

Direction not assertedBalance undeterminableRhea 46232

a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = a (5Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O

Direction not assertedBalance undeterminableRhea 46236

a (9Z)-hexadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = a (9Z,12E)-hexadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O

Direction not assertedBalance undeterminableRhea 46240

hexadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (14E)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O

Direction not assertedBalance undeterminableRhea 46244

hexadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (14Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O

Direction not assertedBalance undeterminableRhea 46248

a (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O

Direction not assertedBalance undeterminableRhea 46252

a (7Z,10Z,13Z,16Z)-docosatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = a (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O

Direction not assertedBalance undeterminableRhea 46256

an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O

Direction not assertedBalance undeterminableRhea 46260

an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = a (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O

Direction not assertedBalance undeterminableRhea 46264

an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = a (4R,8E)-4-hydroxysphingenine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O

Direction not assertedBalance undeterminableRhea 46268

an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = a (4R,8Z)-4-hydroxysphing-8-enine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O

Direction not assertedBalance undeterminableRhea 46272

(S)-malate + H(+) = (S)-lactate + CO2

Direction not assertedBalancedRhea 46276

an N-acylsphing-4-enine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O

Direction not assertedBalance undeterminableRhea 46280

a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O

Direction not assertedBalance undeterminableRhea 46284

(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O

Direction not assertedBalance undeterminableRhea 46288

a 5'-end triphospho-(purine-ribonucleoside) in mRNA + GDP + H(+) = a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + diphosphate

Direction not assertedBalance undeterminableRhea 46292

testosterone + reduced [NADPH--hemoprotein reductase] + O2 = 6beta,17beta-dihydroxyandrost-4-en-3-one + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 46296

testosterone + reduced [NADPH--hemoprotein reductase] + O2 = 2-hydroxytestosterone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 46300

testosterone + reduced [NADPH--hemoprotein reductase] + O2 = 16beta,17beta-dihydroxyandrost-4-en-3-one + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 46304

progesterone + reduced [NADPH--hemoprotein reductase] + O2 = 17alpha-hydroxyprogesterone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 46308

3-oxochol-4-en-22-oyl-CoA + acetyl-CoA = 3,22-dioxochol-4-en-24-oyl-CoA + CoA

Direction not assertedBalancedRhea 46312

GDP-N,N'-diacetylbacillosamine + H2O = 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + GDP + H(+)

Direction not assertedBalancedRhea 46316

3beta-hydroxy-chol-5-ene-24-oyl-CoA + A = 3beta-hydroxy-chol-5,22-dien-24-oyl-CoA + AH2

Direction not assertedBalancedRhea 46320

3-oxochol-4-en-22-oyl-CoA + A = 3-oxochola-4,17-dien-22-oyl-CoA + AH2

Direction not assertedBalancedRhea 46324

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