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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Reactions
Reach

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

20,501–20,550 of 31,435, by identifier

3'-N-debenzoyl-2'-deoxytaxol + reduced [NADPH--hemoprotein reductase] + O2 = 3'-N-debenzoyltaxol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Direction not assertedBalance undeterminableRhea 42492
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+) = 6-lactoyl-5,6,7,8-tetrahydropterin + NADPH + H(+)
Direction not assertedBalancedRhea 42500
N(6)-acetyl-L-lysine + 2-oxoglutarate = 6-acetamido-2-oxohexanoate + L-glutamate
Direction not assertedBalancedRhea 42504
6-acetamido-2-oxohexanoate + NAD(+) + H2O = 5-acetamidopentanoate + CO2 + NADH + H(+)
Direction not assertedBalancedRhea 42508
5-acetamidopentanoate + H2O = 5-aminopentanoate + acetate
Direction not assertedBalancedRhea 42512
L-gulono-1,4-lactone + H2O = L-gulonate + H(+)
Direction not assertedBalancedRhea 42516

uridine(2605) in 23S rRNA = pseudouridine(2605) in 23S rRNA

Direction not assertedBalancedRhea 42520

uridine(1911/1915/1917) in 23S rRNA = pseudouridine(1911/1915/1917) in 23S rRNA

Direction not assertedBalancedRhea 42524

uridine(955/2504/2580) in 23S rRNA = pseudouridine(955/2504/2580) in 23S rRNA

Direction not assertedBalancedRhea 42528

uridine(55) in tRNA = pseudouridine(55) in tRNA

Left to rightBalancedRhea 42532

uridine(65) in tRNA = pseudouridine(65) in tRNA

Direction not assertedBalancedRhea 42536

uridine(13) in tRNA = pseudouridine(13) in tRNA

Direction not assertedBalancedRhea 42540

uridine(32) in tRNA = pseudouridine(32) in tRNA

Direction not assertedBalancedRhea 42544

uridine(746) in 23S rRNA = pseudouridine(746) in 23S rRNA

Direction not assertedBalancedRhea 42548

uridine(31) in tRNA = pseudouridine(31) in tRNA

Direction not assertedBalancedRhea 42552

uridine(2819) in 21S rRNA = pseudouridine(2819) in 21S rRNA

Direction not assertedBalancedRhea 42556

uridine(27/28) in mitochondrial tRNA = pseudouridine(27/28) in mitochondrial tRNA

Direction not assertedBalancedRhea 42560

uridine(38/39) in tRNA = pseudouridine(38/39) in tRNA

Direction not assertedBalancedRhea 42564

2,3-dihydroxy-p-cumate + O2 = 3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+)

Direction not assertedBalancedRhea 42568

3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+) = 2-hydroxy-7-methyl-6-oxo-(2E,4E)-octadienoate + CO2

Direction not assertedBalancedRhea 42572

2-hydroxy-7-methyl-6-oxo-(2E,4E)-octadienoate + H2O = 2-oxopent-4-enoate + 2-methylpropanoate + H(+)

Direction not assertedBalancedRhea 42576

tRNA(Sec) + L-serine + ATP = L-seryl-tRNA(Sec) + AMP + diphosphate + H(+)

Direction not assertedBalancedRhea 42580

1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = 1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate

Left to rightBalancedRhea 42584

1-octadecanoyl-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA

Left to rightBalancedRhea 42588

1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA

Left to rightBalancedRhea 42592

(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = prostaglandin G2

Left to rightBalancedRhea 42596

prostaglandin G2 + AH2 = prostaglandin H2 + A + H2O

Left to rightBalancedRhea 42600

2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = 3-(9Z-octadecenoyl)-sn-glycerol + (9Z)-octadecenoate + H(+)

Left to rightBalancedRhea 42604

a plastoquinone + NADH + (n+1) H(+)(in) = a plastoquinol + NAD(+) + n H(+)(out)

Direction not assertedBalance undeterminableRhea 42608

a plastoquinone + NADPH + (n+1) H(+)(in) = a plastoquinol + NADP(+) + n H(+)(out)

Direction not assertedBalance undeterminableRhea 42612

(Z)-2-methylureidoacrylate + H2O + H(+) = (Z)-2-methylaminoacrylate + NH4(+) + CO2

Direction not assertedBalancedRhea 42620

(Z)-3-ureidoacrylate + H2O + H(+) = (Z)-3-aminoacrylate + NH4(+) + CO2

Direction not assertedBalancedRhea 42624

uridine(747) in 23S rRNA + S-adenosyl-L-methionine = 5-methyluridine(747) in 23S rRNA + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 42628

adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 8-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine

Direction not assertedBalance undeterminableRhea 42632

Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

Direction not assertedBalancedRhea 42636

a 2-demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalance undeterminableRhea 42640

apo-[malonate decarboxylase ACP] + 2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA = holo-[malonate decarboxylase ACP] + diphosphate

Direction not assertedBalance undeterminableRhea 42644

(2,5-ethylene furandicarboxylate)(n) + 2 H2O = (2,5-ethylene furandicarboxylate)(n-1) + 2,5-dicarboxyfuran + ethylene glycol + 2 H(+)

Direction not assertedBalance undeterminableRhea 42648

2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 4 S-adenosyl-L-homocysteine + 3 H(+)

Direction not assertedBalance undeterminableRhea 42652

diphthine methyl ester-[translation elongation factor 2] + H2O = diphthine-[translation elongation factor 2] + methanol + H(+)

Direction not assertedBalance undeterminableRhea 42656

UDP-N-acetyl-alpha-D-glucosamine + NAD(+) = UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose + NADH + H(+)

Direction not assertedBalancedRhea 42660

alpha-L-arabinopyanose + NADP(+) = L-arabinono-1,4-lactone + NADPH + H(+)

Direction not assertedBalancedRhea 42664

L-rhamnofuranose + NADP(+) = L-rhamnono-1,4-lactone + NADPH + H(+)

Direction not assertedBalancedRhea 42668

gamma-L-glutamyl-L-cysteine + hercynine + O2 = gamma-L-glutamyl-hercynylcysteine S-oxide + H2O

Direction not assertedBalancedRhea 42672

L-histidine + L-cysteine + O2 = L-alanin-3-yl L-histidin-5-yl sulfoxide + H2O

Direction not assertedBalancedRhea 42676

gamma-L-glutamyl-hercynylcysteine S-oxide + H2O = S-(hercyn-2-yl)-L-cysteine S-oxide + L-glutamate

Direction not assertedBalancedRhea 42684

S-(hercyn-2-yl)-L-cysteine S-oxide + AH2 + H(+) = ergothioneine + pyruvate + A + NH4(+)

Direction not assertedBalancedRhea 42688

alpha-maltose 1-phosphate + [(1->4)-alpha-D-glucosyl](n) = [(1->4)-alpha-D-glucosyl](n+2) + phosphate

Direction not assertedBalance undeterminableRhea 42692

6-carboxyhexanoyl-[ACP] methyl ester + H2O = 6-carboxyhexanoyl-[ACP] + methanol + H(+)

Direction not assertedBalance undeterminableRhea 42700

hercynine + L-cysteine + O2 = S-(hercyn-2-yl)-L-cysteine S-oxide + H2O

Direction not assertedBalancedRhea 42704

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