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Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
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Reactions
Reach

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Processes
Anatomy
Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

18,701–18,750 of 31,435, by identifier

(2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one + H2O = (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol
Direction not assertedBalancedRhea 35159
minocycline(in) + H(+)(out) = minocycline(out) + H(+)(in)
Direction not assertedBalancedTransportRhea 35163
minocycline(in) = minocycline(out)
Direction not assertedBalancedTransportRhea 35167
novobiocin(in) + H(+)(out) = novobiocin(out) + H(+)(in)
Direction not assertedBalancedTransportRhea 35171
novobiocin(in) = novobiocin(out)
Direction not assertedBalancedTransportRhea 35175
hexanoyl-[ACP] + 7 malonyl-CoA + 6 H(+) = noranthrone + holo-[ACP] + 7 CO2 + 7 CoA + 2 H2O
Direction not assertedBalance undeterminableRhea 35179
5-hydroxythiophene-2-carbonyl-CoA + H2O = 4-carboxy-2-thioxobutanoyl-CoA

Direction not assertedBalancedRhea 35183

noranthrone + O2 = norsolorinic acid + H2O

Direction not assertedBalancedRhea 35191

L-quinate(in) = L-quinate(out)

Direction not assertedBalancedTransportRhea 35195

(S,S)-tartrate(out) = (S,S)-tartrate(in)

Direction not assertedBalancedTransportRhea 35199

IDP + H2O = IMP + phosphate + H(+)

Left to rightBalancedRhea 35207

dIDP + H2O = dIMP + phosphate + H(+)

Left to rightBalancedRhea 35211

XDP + H2O = XMP + phosphate + H(+)

Direction not assertedBalancedRhea 35215

8-oxo-dADP + H2O = 8-oxo-dAMP + phosphate + H(+)

Left to rightBalancedRhea 35219

2-oxo-dADP + H2O = 2-oxo-dAMP + phosphate + H(+)

Left to rightBalancedRhea 35223

rifampicin(in) + H(+)(out) = rifampicin(out) + H(+)(in)

Direction not assertedBalancedTransportRhea 35227

rifampicin(in) = rifampicin(out)

Direction not assertedBalancedTransportRhea 35231

tetracycline(in) + H(+)(out) = tetracycline(out) + H(+)(in)

Direction not assertedBalancedTransportRhea 35235

tetracycline(in) = tetracycline(out)

Direction not assertedBalancedTransportRhea 35239

thiamine diphosphate + ADP + H(+) = adenosine thiamine triphosphate + phosphate

Direction not assertedBalancedRhea 35243

alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli)(in) + ATP + H2O = alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli)(out) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 35247

alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli)(in) + ATP + H2O = alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli)(out) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 35251

lipid A-core(in) + ATP + H2O = lipid A-core(out) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 35255

7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(in) + ATP + H2O = 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(out) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 35259

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + a fatty acid + H(+)

Left to rightBalance undeterminableRhea 35263

ethanol(in) = ethanol(out)

Direction not assertedBalancedTransportRhea 35267

a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA

Direction not assertedBalance undeterminableRhea 35271

3-hydroxyoctadecanoyl-CoA + NAD(+) = 3-oxooctadecanoyl-CoA + NADH + H(+)

Direction not assertedBalancedRhea 35275

hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA

Right to leftBalancedRhea 35279

chloramphenicol(in) + ATP + H2O = chloramphenicol(out) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 35287

11-methyldodecanoyl-CoA + malonyl-CoA + H(+) = 3-oxoisopentadecanoyl-CoA + CO2 + CoA

Direction not assertedBalancedRhea 35291

adenylyl-molybdopterin + tungstate = W-molybdopterin cofactor + AMP + H(+)

Direction not assertedBalancedRhea 35295

3-hydroxyoctadecanoyl-CoA + NADP(+) = 3-oxooctadecanoyl-CoA + NADPH + H(+)

Direction not assertedBalancedRhea 35299

3-hydroxyisopentadecanoyl-CoA + NADP(+) = 3-oxoisopentadecanoyl-CoA + NADPH + H(+)

Direction not assertedBalancedRhea 35303

salicylate + NADH + O2 + H(+) = 2,5-dihydroxybenzoate + NAD(+) + H2O

Direction not assertedBalancedRhea 35307

3-hydroxyisoheptadecanoyl-CoA + NADP(+) = 3-oxoisoheptadecanoyl-CoA + NADPH + H(+)

Direction not assertedBalancedRhea 35311

hexadecanoyl-CoA + malonyl-CoA + H(+) = 3-oxooctadecanoyl-CoA + CO2 + CoA

Left to rightBalancedRhea 35315

octadecanoyl-CoA + malonyl-CoA + H(+) = 3-oxoeicosanoyl-CoA + CO2 + CoA

Left to rightBalancedRhea 35319

(S)-2,3,4,5-tetrahydrodipicolinate + NAD(+) + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADH + H(+)

Direction not assertedBalancedRhea 35323

eicosanoyl-CoA + malonyl-CoA + H(+) = 3-oxodocosanoyl-CoA + CO2 + CoA

Left to rightBalancedRhea 35327

(S)-2,3,4,5-tetrahydrodipicolinate + NADP(+) + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADPH + H(+)

Direction not assertedBalancedRhea 35331

isopentadecanoyl-CoA + malonyl-CoA + H(+) = 3-oxoisoheptadecanoyl-CoA + CO2 + CoA

Direction not assertedBalancedRhea 35335

3-hydroxyicosanoyl-CoA + NADP(+) = 3-oxoeicosanoyl-CoA + NADPH + H(+)

Direction not assertedBalancedRhea 35339

3-hydroxydocosanoyl-CoA + NADP(+) = 3-oxodocosanoyl-CoA + NADPH + H(+)

Direction not assertedBalancedRhea 35343

3-hydroxyoctadecanoyl-CoA = (2E)-octadecenoyl-CoA + H2O

Direction not assertedBalancedRhea 35347

octadecanoyl-CoA + NADP(+) = (2E)-octadecenoyl-CoA + NADPH + H(+)

Right to leftBalancedRhea 35351

3-hydroxyisopentadecanoyl-CoA = (2E)-13-methyltetradecenoyl-CoA + H2O

Direction not assertedBalancedRhea 35355

3-hydroxyisoheptadecanoyl-CoA = (2E)-15-methylhexadecenoyl-CoA + H2O

Direction not assertedBalancedRhea 35359

(2E)-13-methyltetradecenoyl-CoA + NADPH + H(+) = isopentadecanoyl-CoA + NADP(+)

Direction not assertedBalancedRhea 35363

(2E)-15-methylhexadecenoyl-CoA + NADPH + H(+) = isoheptadecanoyl-coA + NADP(+)

Direction not assertedBalancedRhea 35367

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