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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Proteins
Interactions
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Reactions
Reach

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Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

17,051–17,100 of 31,435, by identifier

wogonin 7-O-beta-D-glucuronate + H2O = wogonin + D-glucuronate + H(+)
Direction not assertedBalancedRhea 28326
ITP + H2O = IDP + phosphate + H(+)
Left to rightBalancedRhea 28330
dATP + H2O = dAMP + diphosphate + H(+)
Direction not assertedBalancedRhea 28334
(R)-carnitinyl-CoA = crotonobetainyl-CoA + H2O
Direction not assertedBalancedRhea 28338
dITP + H2O = dIMP + diphosphate + H(+)
Left to rightBalancedRhea 28342
7,8-dihydroneopterin 3'-triphosphate = 7,8-dihydromonapterin 3'-triphosphate
Direction not assertedBalancedRhea 28346
UDP-beta-L-arabinofuranose = UDP-beta-L-arabinopyranose
Direction not asserted

?

Balanced

Rhea 28350

decanoyl-CoA + FAD + H(+) = (2E)-decenoyl-CoA + FADH2

Direction not assertedBalancedRhea 28354

tetradecanoyl-CoA + FAD + H(+) = (2E)-tetradecenoyl-CoA + FADH2

Direction not assertedBalancedRhea 28358

dGTP + H2O = dGMP + diphosphate + H(+)

Left to rightBalancedRhea 28362

UDP-N-acetyl-alpha-D-mannosaminouronate + N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate = beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + UDP + H(+)

Direction not assertedBalancedRhea 28366

oxaloacetate + phosphate = phosphoenolpyruvate + hydrogencarbonate

Direction not assertedBalancedRhea 28370

D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimelate + ATP = UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 28374

N(6)-(D-fructosyl)-L-lysine + ATP = N(6)-(6-phospho-D-fructosyl)-L-lysine + ADP + H(+)

Direction not assertedBalancedRhea 28378

N(6)-(6-phospho-D-fructosyl)-L-lysine + H2O = D-glucose 6-phosphate + L-lysine

Direction not assertedBalancedRhea 28382

UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + di-trans,octa-cis-undecaprenyl phosphate = di-trans,octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP

Direction not assertedBalancedRhea 28386

N(6)-(D-psicosyl)-L-lysine = N(6)-(D-fructosyl)-L-lysine

Direction not assertedBalancedRhea 28390

L-alanyl-L-glutamate = L-alanyl-D-glutamate

Direction not assertedBalancedRhea 28394

L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimelate + H2O = L-alanyl-D-glutamate + meso-2,6-diaminopimelate

Direction not assertedBalancedRhea 28398

alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) + ADP-L-glycero-beta-D-manno-heptose = L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) + ADP + H(+)

Direction not assertedBalancedRhea 28402

XTP + H2O = XDP + phosphate + H(+)

Direction not assertedBalancedRhea 28406

4-(gamma-L-glutamylamino)butanal + NADP(+) + H2O = 4-(gamma-L-glutamylamino)butanoate + NADPH + 2 H(+)

Direction not assertedBalancedRhea 28410

gamma-L-glutamylputrescine + O2 + H2O = 4-(gamma-L-glutamylamino)butanal + H2O2 + NH4(+)

Direction not assertedBalancedRhea 28414

4-(trimethylamino)butanoyl-CoA + (R)-carnitine = (R)-carnitinyl-CoA + 4-(trimethylamino)butanoate

Direction not assertedBalancedRhea 28418

(1E,2S)-2-methylbutanal oxime + reduced [NADPH--hemoprotein reductase] + O2 = 2-hydroxy-2-methylbutanenitrile + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)

Direction not assertedBalance undeterminableRhea 28422

D-allulose 6-phosphate = keto-D-fructose 6-phosphate

Direction not assertedBalancedRhea 28426

D-allose 6-phosphate = D-allulose 6-phosphate

Direction not assertedBalancedRhea 28430

(9Z)-hexadecenoyl-(Kdo)2-lipid IVA (E. coli) + tetradecanoyl-[ACP] = ((9Z)-hexadecenoyl-tetradecanoyl)-(Kdo)2-lipid A + holo-[ACP]

Direction not assertedBalance undeterminableRhea 28434

alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(dodecanoyl)-lipid IVA (E. coli) + tetradecanoyl-[ACP] = alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) + holo-[ACP]

Direction not assertedBalance undeterminableRhea 28438

dodecanoyl-[ACP] + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) = alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(dodecanoyl)-lipid IVA (E. coli) + holo-[ACP]

Direction not assertedBalance undeterminableRhea 28442

1-deoxy-D-xylulose(in) = 1-deoxy-D-xylulose(out)

Direction not assertedBalancedTransportRhea 28446

N(6)-(D-psicosyl)-L-lysine(in) = N(6)-(D-psicosyl)-L-lysine(out)

Direction not assertedBalancedTransportRhea 28450

N(6)-(D-fructosyl)-L-lysine(in) = N(6)-(D-fructosyl)-L-lysine(out)

Direction not assertedBalancedTransportRhea 28454

biotin(in) = biotin(out)

Direction not assertedBalancedTransportRhea 28458

pyridoxal(in) = pyridoxal(out)

Direction not assertedBalancedTransportRhea 28462

pyridoxamine(in) = pyridoxamine(out)

Direction not assertedBalancedTransportRhea 28466

pyridoxine(in) = pyridoxine(out)

Direction not assertedBalancedTransportRhea 28470

D-glucarate(in) + H(+)(in) = D-glucarate(out) + H(+)(out)

Direction not assertedBalancedTransportRhea 28474

galactarate(in) + H(+)(in) = galactarate(out) + H(+)(out)

Direction not assertedBalancedTransportRhea 28478

Fe(2+)(in) = Fe(2+)(out)

Direction not assertedBalancedTransportRhea 28486

K(+)(in) + H(+)(in) = K(+)(out) + H(+)(out)

Direction not assertedBalancedTransportRhea 28490

dimethyl sulfide + a menaquinone + H2O = dimethyl sulfoxide + a menaquinol

Direction not assertedBalance undeterminableRhea 28494

mycothiol + formaldehyde = S-(hydroxymethyl)mycothiol

Direction not assertedBalancedRhea 28498

S-(hydroxymethyl)mycothiol + NAD(+) = S-formylmycothiol + NADH + H(+)

Direction not assertedBalancedRhea 28502

alpha-Kdo-(2->6)-lipid IVA (E. coli) + ATP = 4-O-phospho-alpha-Kdo-(2->6)-lipid IVA (E. coli) + ADP + H(+)

Direction not assertedBalancedRhea 28506

arbutin 6-phosphate + H2O = beta-D-glucose 6-phosphate + hydroquinone

Direction not assertedBalancedRhea 28510

(R)-carnitine + ATP + CoA = (R)-carnitinyl-CoA + AMP + diphosphate

Direction not assertedBalancedRhea 28514

D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O = D-glycero-beta-D-manno-heptose 1-phosphate + phosphate

Direction not assertedBalancedRhea 28518

D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H2O = D-glycero-alpha-D-manno-heptose 1-phosphate + phosphate

Direction not assertedBalancedRhea 28522

crotonobetainyl-CoA + (R)-carnitine = crotonobetaine + (R)-carnitinyl-CoA

Direction not assertedBalancedRhea 28526

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