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CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Reactions
Reach

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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

16,451–16,500 of 18,558 reactions from Rhea

D-methionine + O2 + H2O = 4-methylsulfanyl-2-oxobutanoate + H2O2 + NH4(+)
Left to rightBalancedRhea 78207
D-leucine + O2 + H2O = 4-methyl-2-oxopentanoate + H2O2 + NH4(+)
Left to rightBalancedRhea 78211
D-glutamine + O2 + H2O = 2-oxoglutaramate + H2O2 + NH4(+)
Direction not assertedBalancedRhea 78215
D-arginine + O2 + H2O = 5-guanidino-2-oxopentanoate + H2O2 + NH4(+)
Direction not assertedBalancedRhea 78219
D-allo-isoleucine + O2 + H2O = (S)-3-methyl-2-oxopentanoate + H2O2 + NH4(+)
Direction not assertedBalancedRhea 78223
D-histidine + O2 + H2O = 3-(imidazol-5-yl)pyruvate + H2O2 + NH4(+)
Direction not assertedBalancedRhea 78227
queuosine(34) in tRNA(Tyr) + UDP-alpha-D-galactose = O-5''-beta-D-galactosylqueuosine(34) in tRNA(Tyr) + UDP + H(+)

Left to rightBalancedRhea 78231

D-isoleucine + O2 + H2O = (R)-3-methyl-2-oxopentanoate + H2O2 + NH4(+)

Direction not assertedBalancedRhea 78235

D-allo-threonine + O2 + H2O = (R)-3-hydroxy-2-oxobutanoate + H2O2 + NH4(+)

Direction not assertedBalancedRhea 78239

D-asparagine + O2 + H2O = 2-oxosuccinamate + H2O2 + NH4(+)

Direction not assertedBalancedRhea 78243

D-tryptophan + O2 + H2O = indole-3-pyruvate + H2O2 + NH4(+)

Left to rightBalancedRhea 78247

D-threonine + O2 + H2O = (S)-3-hydroxy-2-oxobutanoate + H2O2 + NH4(+)

Direction not assertedBalancedRhea 78251

D-ornithine + O2 + H2O = 5-amino-2-oxopentanoate + H2O2 + NH4(+)

Direction not assertedBalancedRhea 78255

D-proline + O2 = 1-pyrroline-2-carboxylate + H2O2

Left to rightBalancedRhea 78259

9-cis-retinol + a fatty acyl-CoA = 9-cis-retinyl ester + CoA

Left to rightBalance undeterminableRhea 78263

omega-dicarboxyl-CoA + H2O = a dicarboxylate + CoA + H(+)

Direction not assertedBalance undeterminableRhea 78267

(2E,6E)-farnesyl diphosphate + H2O = (+)-delta-cadinol + diphosphate

Direction not assertedBalancedRhea 78271

(2E,6E,10E)-geranylgeranyl diphosphate = delta-araneosene + diphosphate

Direction not assertedBalancedRhea 78275

(2E,6E,10E,14E)-geranylfarnesyl diphosphate = somaliensene A + diphosphate

Direction not assertedBalancedRhea 78279

(2E,6E,10E,14E)-geranylfarnesyl diphosphate = (-)-somaliensene B + diphosphate

Direction not assertedBalancedRhea 78283

(2E,6E,10E)-geranylgeranyl diphosphate = variediene + diphosphate

Direction not assertedBalancedRhea 78287

(2E,6E,10E,14E)-geranylfarnesyl diphosphate = (R,2E)-alpha-cericerene + diphosphate

Direction not assertedBalancedRhea 78291

[2-(trimethylamino)ethyl]phosphonate + 2-oxoglutarate + O2 = 2-(trimethylamino)-vinylphosphonate + succinate + CO2 + H2O

Direction not assertedBalancedRhea 78295

guanosine(34) in tRNA(Tyr) + queuine = queuosine(34) in tRNA(Tyr) + guanine

Direction not assertedBalancedRhea 78299

guanosine(34) in tRNA(Asp) + queuine = queuosine(34) in tRNA(Asp) + guanine

Direction not assertedBalancedRhea 78303

2-(trimethylamino)-vinylphosphonate + 2-oxoglutarate + O2 = methyldehydrofosmidomycin + formaldehyde + succinate + CO2

Direction not assertedBalancedRhea 78307

dAMP + dATP = 2 dADP

Direction not assertedBalancedRhea 78311

ADP + ATP = adenosine 5'-tetraphosphate + AMP

Direction not assertedBalancedRhea 78315

a III(4)-a-Fuc-Lc4Cer(d18:1(4E)) + GDP-beta-L-fucose = a lactoside IV(2),III(4)-a-[Fuc]2-Lc4Cer(d18:1(4E)) + GDP + H(+)

Direction not assertedBalance undeterminableRhea 78319

glyoxylate + L-glutamine = 2-oxoglutaramate + glycine

Direction not assertedBalancedRhea 78323

L-erythrulose + D-erythrose 4-phosphate = glycolaldehyde + beta-D-fructose 6-phosphate

Direction not assertedBalancedRhea 78327

UTP + UMP = 2 UDP

Direction not assertedBalancedRhea 78331

UTP + ATP = 2',3'-cUAMP + 2 diphosphate

Direction not assertedBalancedRhea 78335

2',3'-cGAMP + H2O = 5'-pGpA(2'-5') + H(+)

Left to rightBalancedRhea 78339

5'-pGpA(2'-5') + H2O = 5'-GpA(2'-5') + phosphate

Left to rightBalancedRhea 78343

N-acyl-1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)

Direction not assertedBalance undeterminableRhea 78347

a 1,2-diacyl-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phospho-L-serine

Left to rightBalance undeterminableRhea 78351

a 1,2-diacyl-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine = a 2-acyl-sn-glycero-3-phospho-L-serine + 1-O-acyl-N-(acetyl)-sphing-4-enine

Left to rightBalance undeterminableRhea 78355

a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine = 2-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-O-acyl-N-(acetyl)-sphing-4-enine

Left to rightBalance undeterminableRhea 78359

a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine = 1-O-acyl-N-(acetyl)-sphing-4-enine + 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)

Left to rightBalance undeterminableRhea 78363

N(tau)-methylhistamine + O2 + H2O = 1-methylimidazole-4-acetaldehyde + H2O2 + NH4(+)

Left to rightBalancedRhea 78367

S-nitrosoglutathione + NADH + H(+) = S-(hydroxysulfenamide)glutathione + NAD(+)

Left to rightBalancedRhea 78371

S-nitroso-CoA + NADPH + H(+) = sulfinamide-CoA + NADP(+)

Left to rightBalancedRhea 78375

S-nitroso-CoA + L-cysteinyl-[protein] = S-nitroso-L-cysteinyl-[protein] + CoA

Left to rightBalance undeterminableRhea 78379

L-cysteinyl-[SCAN] + S-nitroso-CoA = S-nitroso-L-cysteinyl-[SCAN] + CoA

Left to rightBalance undeterminableRhea 78383

S-nitroso-L-cysteinyl-[SCAN] + L-cysteinyl-[protein] = L-cysteinyl-[SCAN] + S-nitroso-L-cysteinyl-[protein]

Left to rightBalance undeterminableRhea 78387

D-mannose(out) = D-mannose(in)

Direction not assertedBalancedTransportRhea 78391

bilirubin IXbeta + NADP(+) = biliverdin IXbeta + NADPH + H(+)

Right to leftBalancedRhea 78395

(2E,6E,10E,14E)-geranylfarnesyl diphosphate = astellifadiene + diphosphate

Direction not assertedBalancedRhea 78399

(2E,6E,10E)-geranylgeranyl diphosphate + H2O = (+)-penichrysol + diphosphate

Direction not assertedBalancedRhea 78403

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