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CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

14,951–15,000 of 18,558 reactions from Rhea

5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(out) + glutarate(in) = 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(in) + glutarate(out)
Direction not assertedBalancedTransportRhea 72175
tauro-beta-muricholate(out) + 2 Na(+)(out) = tauro-beta-muricholate(in) + 2 Na(+)(in)
Direction not assertedBalancedTransportRhea 72179
creatinine(in) + H(+)(out) = creatinine(out) + H(+)(in)
Direction not assertedBalancedTransportRhea 72183
sucrose(out) + H(+)(out) = sucrose(in) + H(+)(in)
Direction not assertedBalancedTransportRhea 72187
cholesterol + 2 reduced [NADPH--hemoprotein reductase] + 2 O2 = (16S,22S)-dihydroxycholesterol + 2 oxidized [NADPH--hemoprotein reductase] + 2 H2O + 2 H(+)
Direction not assertedBalance undeterminableRhea 72191
citrate(out) + 3 Na(+)(out) = citrate(in) + 3 Na(+)(in)
Direction not asserted

Balanced

Transport

Rhea 72195

Ca(2+)(in) + 2 H(+)(out) = Ca(2+)(out) + 2 H(+)(in)

Direction not assertedBalancedTransportRhea 72199

hydrogencarbonate(in) + 2 chloride(out) = hydrogencarbonate(out) + 2 chloride(in)

Direction not assertedBalancedTransportRhea 72203

2 hydrogencarbonate(in) + chloride(out) = 2 hydrogencarbonate(out) + chloride(in)

Direction not assertedBalancedTransportRhea 72207

(+)-isoborneol + NAD(+) = (1S,4S)-camphor + NADH + H(+)

Direction not assertedBalancedRhea 72211

2 hydrogencarbonate(out) + Na(+)(out) = 2 hydrogencarbonate(in) + Na(+)(in)

Direction not assertedBalancedTransportRhea 72215

3 hydrogencarbonate(out) + Na(+)(out) = 3 hydrogencarbonate(in) + Na(+)(in)

Direction not assertedBalancedTransportRhea 72219

4-hydroxy-L-proline(out) + chloride(out) + 2 Na(+)(out) = 4-hydroxy-L-proline(in) + chloride(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 72223

sarcosine(out) + chloride(out) + 2 Na(+)(out) = sarcosine(in) + chloride(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 72227

N-methyl-L-proline(out) + chloride(out) + 2 Na(+)(out) = N-methyl-L-proline(in) + chloride(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 72231

2-methyl-2-(methylamino)propanoate(out) + chloride(out) + 2 Na(+)(out) = 2-methyl-2-(methylamino)propanoate(in) + chloride(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 72235

estrone 3-sulfate(out) + L-glutamate(in) = estrone 3-sulfate(in) + L-glutamate(out)

Left to rightBalancedTransportRhea 72239

catechol + S-adenosyl-L-methionine = guaiacol + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 72243

(R)-noradrenaline + S-adenosyl-L-methionine = (R)-normetanephrine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 72247

(R)-adrenaline + S-adenosyl-L-methionine = (R)-metanephrine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 72251

dopamine + S-adenosyl-L-methionine = 3-methoxytyramine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 72255

L-dopa + S-adenosyl-L-methionine = 3-O-methyl-L-dopa + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 72259

oxalate(in) + chloride(out) = oxalate(out) + chloride(in)

Direction not assertedBalancedTransportRhea 72263

formate(in) + chloride(out) = formate(out) + chloride(in)

Direction not assertedBalancedTransportRhea 72267

oxalate(in) + formate(out) = oxalate(out) + formate(in)

Direction not assertedBalancedTransportRhea 72271

oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in)

Direction not assertedBalancedTransportRhea 72275

5-carboxymethylaminomethyl-2-thiouridine(34) in tRNA + A + H2O = 5-aminomethyl-2-thiouridine(34) in tRNA + glyoxylate + AH2

Direction not assertedBalancedRhea 72279

a methoxylated aromatic compound + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) = a phenol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]

Direction not assertedBalance undeterminableRhea 72283

2,2-dimethylsuccinate(out) + 3 Na(+)(out) = 2,2-dimethylsuccinate(in) + 3 Na(+)(in)

Direction not assertedBalancedTransportRhea 72287

2,3-dimethylsuccinate(out) + 3 Na(+)(out) = 2,3-dimethylsuccinate(in) + 3 Na(+)(in)

Direction not assertedBalancedTransportRhea 72291

malate(out) + 3 Na(+)(out) = malate(in) + 3 Na(+)(in)

Direction not assertedBalancedTransportRhea 72295

3,3',5-triiodo-L-thyronine(out) + L-glutamate(in) = 3,3',5-triiodo-L-thyronine(in) + L-glutamate(out)

Left to rightBalancedTransportRhea 72299

L-thyroxine(out) + L-glutamate(in) = L-thyroxine(in) + L-glutamate(out)

Left to rightBalancedTransportRhea 72303

taurocholate(out) + L-glutamate(in) = taurocholate(in) + L-glutamate(out)

Left to rightBalancedTransportRhea 72307

taurocholate(out) + glutathione(in) = taurocholate(in) + glutathione(out)

Direction not assertedBalancedTransportRhea 72311

leukotriene C4(out) + glutathione(in) = leukotriene C4(in) + glutathione(out)

Direction not assertedBalancedTransportRhea 72315

urate(out) + n chloride(in) = urate(in) + n chloride(out)

Direction not assertedBalance undeterminableTransportRhea 72319

thiosulfate(out) + 3 Na(+)(out) = thiosulfate(in) + 3 Na(+)(in)

Direction not assertedBalancedTransportRhea 72323

Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + vanillate + H(+) = methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] + 3,4-dihydroxybenzoate

Direction not assertedBalance undeterminableRhea 72327

3-hydroxy-4-methoxybenzoate + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) = methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] + 3,4-dihydroxybenzoate

Direction not assertedBalance undeterminableRhea 72331

syringate + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) = 3-O-methylgallate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]

Direction not assertedBalance undeterminableRhea 72335

guaiacol + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) = methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] + catechol

Direction not assertedBalance undeterminableRhea 72339

3-methoxyphenol + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) = resorcinol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]

Direction not assertedBalance undeterminableRhea 72343

veratrole + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) = 3-methoxyphenol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]

Direction not assertedBalance undeterminableRhea 72347

glycocholate(out) + glutarate(in) = glycocholate(in) + glutarate(out)

Direction not assertedBalancedTransportRhea 72351

dehydroepiandrosterone 3-sulfate(out) + glutarate(in) = dehydroepiandrosterone 3-sulfate(in) + glutarate(out)

Direction not assertedBalancedTransportRhea 72355

glutarate(in) + succinate(out) = glutarate(out) + succinate(in)

Direction not assertedBalancedTransportRhea 72359

hydrogencarbonate(in) + chloride(out) = hydrogencarbonate(out) + chloride(in)

Direction not assertedBalancedTransportRhea 72363

estrone 3-sulfate(out) + succinate(in) = estrone 3-sulfate(in) + succinate(out)

Direction not assertedBalancedTransportRhea 72367

dehydroepiandrosterone 3-sulfate(out) + succinate(in) = dehydroepiandrosterone 3-sulfate(in) + succinate(out)

Direction not assertedBalancedTransportRhea 72371

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