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ProteinsTransporters and enzymes
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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Reference

Evidence

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Reach

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Cell types
Organisms
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

12,751–12,800 of 12,877 reactions from Human-GEM

H2O[c] + NAD+[c] + heptanal[c] = 2 H+[c] + heptylic acid[c] + NADH[c]
Left to rightBalancedEC 1.2.1.3, 1.2.1.5Fatty acid metabolismHuman-GEM MAR20063
2-trans,6-trans-farnesal[r] + H2O[r] + NAD+[r] = 2 H+[r] + NADH[r] + (2E,6E)-farnesoate[r]
Left to rightBalancedEC 1.2.1.94Insect hormone biosynthesisHuman-GEM MAR20064
2-trans,6-trans-farnesal[c] + H2O[c] + NAD+[c] = 2 H+[c] + NADH[c] + (2E,6E)-farnesoate[c]
Left to rightBalancedEC 1.2.1.94Insect hormone biosynthesisHuman-GEM MAR20065
NAD+[c] + all-trans-4-hydroxyretinol[c] = H+[c] + NADH[c] + all-trans-4-hydroxyretinal[c]
Left to rightBalancedEC 1.1.1.1Fatty acid metabolismHuman-GEM MAR20067
4-oxoretinol[c] + NAD+[c] = H+[c] + NADH[c] + all-trans-4-oxoretinal[c]
Left to rightBalancedEC 1.1.1.-

Fatty acid degradation

Human-GEM MAR20068

2-(alpha-hydroxyethyl)thiamine-diphosphate[m] + lipoamide[m] = S-acetyldihydrolipoamide[m] + thiamin-PP[m]

Left to rightBalancedGlycolysis / GluconeogenesisHuman-GEM MAR20069

H2O[c] + sedoheptulose-1,7-bisphosphate[c] = Pi[c] + sedoheptulose-7-phosphate[c]

Left to rightBalancedEC 3.1.3.11Pentose phosphate pathwayHuman-GEM MAR20070

epsilon-(gamma-L-Glutamyl)-L-lysine[c] = 5-oxoproline[c] + lysine[c]

Left to rightBalancedEC 4.3.2.8Alanine, aspartate and glutamate metabolismHuman-GEM MAR20071

epsilon-(gamma-L-Glutamyl)-L-lysine[n] = 5-oxoproline[n] + lysine[n]

Left to rightBalancedEC 4.3.2.8Alanine, aspartate and glutamate metabolismHuman-GEM MAR20072

H2O[r] + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphinganine[r] = arachidonate[r] + sphinganine[r]

Left to rightBalancedEC 3.5.1.23Fatty acid metabolismHuman-GEM MAR20073

H2O[g] + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphinganine[g] = arachidonate[g] + sphinganine[g]

Left to rightBalancedEC 3.5.1.23Fatty acid metabolismHuman-GEM MAR20074

H2O[r] + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-(4R)-hydroxysphinganine[r] = arachidonate[r] + phytosphingosine[r]

Left to rightBalancedEC 3.5.1.23Fatty acid metabolismHuman-GEM MAR20075

H2O[g] + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-(4R)-hydroxysphinganine[g] = arachidonate[g] + phytosphingosine[g]

Left to rightBalancedEC 3.5.1.23Fatty acid metabolismHuman-GEM MAR20076

H2O[r] + N-(11Z-eicosenoyl)-sphing-4-enine[r] = cis-gondoic acid[r] + sphingosine[r]

Left to rightBalancedEC 3.5.1.23Fatty acid metabolismHuman-GEM MAR20077

H2O[g] + N-(11Z-eicosenoyl)-sphing-4-enine[g] = cis-gondoic acid[g] + sphingosine[g]

Left to rightBalancedEC 3.5.1.23Fatty acid metabolismHuman-GEM MAR20078

H2O[r] + N-(11Z-eicosenoyl)-sphinganine[r] = cis-gondoic acid[r] + sphinganine[r]

Left to rightBalancedEC 3.5.1.23Fatty acid metabolismHuman-GEM MAR20079

H2O[g] + N-(11Z-eicosenoyl)-sphinganine[g] = cis-gondoic acid[g] + sphinganine[g]

Left to rightBalancedEC 3.5.1.23Fatty acid metabolismHuman-GEM MAR20080

H2O[r] + N-(11Z-eicosenoyl)-(4R)-hydroxysphinganine[r] = cis-gondoic acid[r] + phytosphingosine[r]

Left to rightBalancedEC 3.5.1.23Fatty acid metabolismHuman-GEM MAR20081

H2O[g] + N-(11Z-eicosenoyl)-(4R)-hydroxysphinganine[g] = cis-gondoic acid[g] + phytosphingosine[g]

Left to rightBalancedEC 3.5.1.23Fatty acid metabolismHuman-GEM MAR20082

H2O[r] + N-(9Z-octadecenoyl)-sphing-4-enine[r] = oleate[r] + sphingosine[r]

Left to rightBalancedEC 3.5.1.23Fatty acid metabolismHuman-GEM MAR20083

H2O[g] + N-(9Z-octadecenoyl)-sphing-4-enine[g] = elaidate[g] + sphingosine[g]

Left to rightBalancedEC 3.5.1.23Fatty acid metabolismHuman-GEM MAR20084

H2O[r] + N-(9Z-octadecenoyl)-sphinganine[r] = oleate[r] + sphinganine[r]

Left to rightBalancedEC 3.5.1.23Fatty acid metabolismHuman-GEM MAR20085

H2O[g] + N-(9Z-octadecenoyl)-sphinganine[g] = elaidate[g] + sphinganine[g]

Left to rightBalancedEC 3.5.1.23Fatty acid metabolismHuman-GEM MAR20086

H2O[r] + N-(9Z-octadecenoyl)-(4R)-hydroxysphinganine[r] = oleate[r] + phytosphingosine[r]

Left to rightBalancedEC 3.5.1.23Fatty acid metabolismHuman-GEM MAR20087

H2O[g] + N-(9Z-octadecenoyl)-(4R)-hydroxysphinganine[g] = elaidate[g] + phytosphingosine[g]

Left to rightBalancedEC 3.5.1.23Fatty acid metabolismHuman-GEM MAR20088

farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]

Left to rightBalancedEC 2.5.1.-, 2.5.1.141Porphyrin metabolismHuman-GEM MAR20090

farnesyl-PP[c] + H2O[c] + heme[c] = PPi[c] + Fe(II)-heme o[c]

Left to rightBalancedEC 2.5.1.-, 2.5.1.141Porphyrin metabolismHuman-GEM MAR20091

farnesyl-PP[n] + H2O[n] + heme[n] = PPi[n] + Fe(II)-heme o[n]

Left to rightBalancedEC 2.5.1.-, 2.5.1.141Porphyrin metabolismHuman-GEM MAR20092

H2O[c] + Hexadecenoyl Ethanolamide, C16:1-Ethanolamide (Delta 9)[c] = ethanolamine[c] + palmitate[c]

Left to rightBalancedEC 3.5.1.60, 3.5.1.99Fatty acid metabolismHuman-GEM MAR20093

H2O[c] + C12:0-Ethanolamide, Didecanoyl Ethanolamide[c] = ethanolamine[c] + lauric acid[c]

Left to rightBalancedEC 3.5.1.99Fatty acid metabolismHuman-GEM MAR20094

H2O[c] + C14:0-Ethanolamide, Tetradecanoyl Ethanolamide[c] = ethanolamine[c] + myristic acid[c]

Left to rightBalancedEC 3.5.1.99Fatty acid metabolismHuman-GEM MAR20095

H2O[c] + N-hexadecanoylsphing-4-enine[c] = palmitate[c] + sphingosine[c]

Left to rightBalancedEC 3.5.1.23Fatty acid metabolismHuman-GEM MAR20096

H2O[c] + N-dodecanoylsphing-4-enine[c] = lauric acid[c] + sphingosine[c]

Left to rightBalancedEC 3.5.1.23Fatty acid metabolismHuman-GEM MAR20097

farnesyl-PP[r] + 5 isopentenyl-pPP[r] = dehydrodolichol-diphosphate[r] + 5 PPi[r]

Left to rightBalancedEC 2.5.1.87Terpenoid backbone biosynthesisHuman-GEM MAR20098

H2O[n] + 2-O-acetyl-ADP-D-ribose[n] = acetate[n] + ADP-ribose[n] + H+[n]

Left to rightBalancedEC 3.1.1.106IsolatedHuman-GEM MAR20099

H2O[n] + alpha-NAD(+)[n] = ADP-ribose[n] + H+[n] + nicotinamide[n]

Left to rightBalancedEC 3.1.1.106IsolatedHuman-GEM MAR20100

H2O[n] + 3-O-acetyl-ADP-D-ribose[n] = acetate[n] + ADP-ribose[n] + H+[n]

Left to rightBalancedEC 3.1.1.106, 3.1.1.yIsolatedHuman-GEM MAR20101

2-Trans,6-Trans,10-Trans-Geranylgeranyl Diphosphate[c] + menadiol[c] = PPi[c] + menaquinol-4[c]

Left to rightBalancedEC 2.5.1.M22IsolatedHuman-GEM MAR20102

2-Trans,6-Trans,10-Trans-Geranylgeranyl Diphosphate[r] + menadiol[r] = PPi[r] + menaquinol-4[r]

Left to rightBalancedEC 2.5.1.M22IsolatedHuman-GEM MAR20103

2-Trans,6-Trans,10-Trans-Geranylgeranyl Diphosphate[g] + menadiol[g] = PPi[g] + menaquinol-4[g]

Left to rightBalancedEC 2.5.1.M22IsolatedHuman-GEM MAR20104

2-Trans,6-Trans,10-Trans-Geranylgeranyl Diphosphate[n] + menadiol[n] = PPi[n] + menaquinol-4[n]

Left to rightBalancedEC 2.5.1.M22IsolatedHuman-GEM MAR20105

4-hydroxybenzoate[c] + all-trans-decaprenyl-diphosphate[c] = 3-decaprenyl-4-hydroxybenzoate[c] + PPi[c]

Left to rightBalancedEC 2.5.1.39Ubiquinone and other terpenoid-quinone biosynthesisHuman-GEM MAR20106

4-hydroxybenzoate[r] + all-trans-decaprenyl-diphosphate[r] = 3-decaprenyl-4-hydroxybenzoate[r] + PPi[r]

Left to rightBalancedEC 2.5.1.39Ubiquinone and other terpenoid-quinone biosynthesisHuman-GEM MAR20107

4-hydroxybenzoate[g] + all-trans-decaprenyl-diphosphate[g] = 3-decaprenyl-4-hydroxybenzoate[g] + PPi[g]

Left to rightBalancedEC 2.5.1.39Ubiquinone and other terpenoid-quinone biosynthesisHuman-GEM MAR20108

4-hydroxybenzoate[n] + all-trans-decaprenyl-diphosphate[n] = 3-decaprenyl-4-hydroxybenzoate[n] + PPi[n]

Left to rightBalancedEC 2.5.1.39Ubiquinone and other terpenoid-quinone biosynthesisHuman-GEM MAR20109

H+[m] + OAA[m] = CO2[m] + pyruvate[m]

Left to rightBalancedEC 4.1.1.112MiscellaneousHuman-GEM MAR20110

acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]

Left to rightBalancedEC 2.3.3.9MiscellaneousHuman-GEM MAR20111

apoC-lys_btn[m] + ATP[m] + HCO3-[m] = ADP[m] + carboxybiotin-carboxyl-carrier[m] + H+[m] + Pi[m]

Left to rightBalance undeterminableEC 6.4.1.2Fatty acid biosynthesis (even-chain)Human-GEM MAR20112

[apocarboxylase][c] = [apocarboxylase][m]

ReversibleBalance undeterminableTransportTransport reactionsHuman-GEM MAR20113

FADH2[x] + O2[x] = FAD[x] + H2O2[x]

Left to rightBalancedMiscellaneousHuman-GEM MAR20114

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