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Subsystem: Porphyrin metabolism Remove
28 reactions in Porphyrin metabolism
Fe2+[m] + protoporphyrin[m] = 2 H+[m] + heme[m]
Left to rightBalancedEC 4.98.1.1Human-GEM MAR01044
3 O2[m] + 2 protoporphyrinogen IX[m] = 6 H2O[m] + 2 protoporphyrin[m]
Left to rightBalancedEC 1.3.3.4Human-GEM MAR01643
4 Fe2+[e] + 4 H+[e] + O2[e] = 4 Fe3+[e] + 2 H2O[e]
Left to rightBalancedEC 1.16.3.1Human-GEM MAR03991
2-amino-3-oxoadipate[m] + H+[m] = 5-aminolevulinate[m] + CO2[m]
Left to rightBalancedEC 2.3.1.37Human-GEM MAR04657
2 5-aminolevulinate[c] = H+[c] + 2 H2O[c] + porphobilinogen[c]
Left to rightBalancedEC 4.2.1.24Human-GEM MAR04744
H2O[c] + 4 porphobilinogen[c] = 4 H+[c] + hydroxymethylbilane[c] + 4 NH3[c]
Left to rightBalancedEC 2.5.1.61Human-GEM MAR04746
hydroxymethylbilane[c] = H2O[c] + uroporphyrinogen III[c]
Left to rightBalancedEC 4.2.1.75Human-GEM MAR04748
4 H+[c] + uroporphyrinogen III[c] = 4 CO2[c] + coproporphyrinogen III[c]
Left to rightBalancedEC 4.1.1.37Human-GEM MAR04750
coproporphyrinogen III[c] + 2 H+[c] + O2[c] = 2 CO2[c] + 2 H2O[c] + protoporphyrinogen IX[c]
Left to rightBalancedEC 1.3.3.3Human-GEM MAR04752
3 O2[m] + protoporphyrinogen IX[m] = 3 H2O2[m] + protoporphyrin[m]
Left to rightBalancedEC 1.3.3.4Human-GEM MAR04755
3 O2[c] + protoporphyrinogen IX[c] = 3 H2O2[c] + protoporphyrin[c]
Left to rightBalancedEC 1.3.3.4Human-GEM MAR04757
apocytochrome-C[m] + heme[m] = cytochrome-C[m]
Left to rightBalancedEC 4.4.1.17Human-GEM MAR04762
3 FADH2[c] + 2 H+[c] + hemoglobin[c] + 3 O2[c] = biliverdin[c] + CO[c] + 3 FAD[c] + Fe3+[c] + globin[c] + 3 H2O[c]
Left to rightUnbalancedEC 1.14.14.18Human-GEM MAR04763
biliverdin[c] + H+[c] + NADH[c] = bilirubin[c] + NAD+[c]
Left to rightBalancedEC 1.3.1.24Human-GEM MAR04764
6 H+[c] + uroporphyrin III[c] = uroporphyrinogen III[c]
ReversibleUnbalancedHuman-GEM MAR04768
6 H+[c] + uroporphyrin I[c] = uroporphyrinogen III[c]
ReversibleUnbalancedHuman-GEM MAR04769
coproporphyrin III[c] + 6 H+[c] = coproporphyrinogen III[c]
ReversibleUnbalancedHuman-GEM MAR04770
H2O[c] + uroporphyrinogen I[c] = hydroxymethylbilane[c]
ReversibleBalancedHuman-GEM MAR04771
4 H+[c] + uroporphyrinogen I[c] = 4 CO2[c] + coproporphyrinogen I[c]
Left to rightBalancedEC 4.1.1.37Human-GEM MAR04772
coproporphyrin I[c] + 6 H+[c] = coproporphyrinogen I[c]
ReversibleUnbalancedHuman-GEM MAR04773
ascorbate[e] + 2 Fe3+[e] = dehydroascorbic acid[e] + 2 Fe2+[e] + 2 H+[e]
Left to rightBalancedEC 1.-.-.-Human-GEM MAR06395
biliverdin[c] + H+[c] + NADPH[c] = bilirubin[c] + NADP+[c]
Left to rightBalancedEC 1.5.1.30, 1.3.1.24Human-GEM MAR08634
globin[c] + heme[c] = hemoglobin[c]
Left to rightBalancedHuman-GEM MAR09717
1.5 O2[c] + protoporphyrinogen IX[c] = 3 H2O[c] + protoporphyrin[c]
Left to rightBalancedHuman-GEM MAR11316
Fe2+[c] + protoporphyrin[c] = 2 H+[c] + heme[c]
Left to rightBalancedHuman-GEM MAR11406
Left to rightBalancedEC 2.5.1.-, 2.5.1.141Human-GEM MAR20090
Left to rightBalancedEC 2.5.1.-, 2.5.1.141Human-GEM MAR20091
Left to rightBalancedEC 2.5.1.-, 2.5.1.141Human-GEM MAR20092