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12,451–12,500 of 12,877 reactions from Human-GEM
simvastatin dihydroxy acid form[c] = simvastatin dihydroxy acid form[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12840
ATP[c] + H2O[c] + simvastatin lactone form[c] = ADP[c] + H+[c] + Pi[c] + simvastatin lactone form[e]
Left to rightBalancedTransportEC 7.6.2.2Drug metabolismHuman-GEM MAR12841
simvastatin-acyl-glucuronide[r] = glucuronate[r] + simvastatin lactone form[r]
Left to rightBalancedDrug metabolismHuman-GEM MAR12842
UDP-glucuronate[r] + simvastatin dihydroxy acid form[r] = UDP[r] + simvastatin-acyl-glucuronide[r]
Left to rightBalancedEC 2.4.1.17Drug metabolismHuman-GEM MAR12843
H2O[c] + simvastatin lactone form[c] = H+[c] + simvastatin dihydroxy acid form[c]
Left to rightBalancedEC 3.1.1.2Drug metabolismHuman-GEM MAR12844
ATP[c] + simvastatin dihydroxy acid form[c] = AMP[c] + PPi[c] + simvastatin lactone form[c]
Left to rightBalancedDrug metabolismHuman-GEM MAR12845
simvastatin lactone form[e] = simvastatin lactone form[c]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12846
HCO3-[c] + simvastatin lactone form[e] = HCO3-[e] + simvastatin lactone form[c]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12847
PAPS[c] + thiomethyl-conjugate-acetaminophen[c] = H+[c] + PAP[c] + sulphate-conjugate of thiomethyl-acetaminophen[c]
Left to rightBalancedDrug metabolismHuman-GEM MAR12848
ATP[c] + H2O[c] + sulphate-conjugate of thiomethyl-acetaminophen[c] = ADP[c] + H+[c] + Pi[c] + sulphate-conjugate of thiomethyl-acetaminophen[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12849
ATP[c] + H2O[c] + sulphate-conjugate-acetaminophen[c] = ADP[c] + H+[c] + Pi[c] + sulphate-conjugate-acetaminophen[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12850
Tacrolimus[e] = Tacrolimus[c]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12851
ATP[c] + H2O[c] + Tacrolimus[c] = ADP[c] + H+[c] + Pi[c] + Tacrolimus[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12852
taurine conjugate of S-ibuprofen[c] = taurine conjugate of S-ibuprofen[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12853
fluvastatin[c] = threo-isomer of fluvastain[c]
Left to rightBalancedDrug metabolismHuman-GEM MAR12854
threo-isomer of fluvastain[c] = threo-isomer of fluvastain[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12855
H+[r] + NADPH[r] + O2[r] + thiomethyl-conjugate-acetaminophen[r] = H2O[r] + NADP+[r] + thiomethyl-sulphoxide-conjugate-acetaminophen[r]
Left to rightBalancedDrug metabolismHuman-GEM MAR12856
fluvstatin-glucuronide[r] = glucuronate[r] + trans-lactone-fluvastatin[r]
Left to rightBalancedDrug metabolismHuman-GEM MAR12857
trans-lactone-fluvastatin[c] = trans-lactone-fluvastatin[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12858
chloride[e] + Torasemide-M1[c] = chloride[c] + Torasemide-M1[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12859
H+[r] + NADPH[r] + O2[r] + Torasemide[r] = H2O[r] + NADP+[r] + Torasemide-M1[r]
Left to rightBalancedEC 1.14.13.-Drug metabolismHuman-GEM MAR12860
chloride[e] + Torasemide-M3[c] = chloride[c] + Torasemide-M3[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12861
H+[r] + NADPH[r] + O2[r] + Torasemide[r] = H2O[r] + NADP+[r] + Torasemide-M3[r]
Left to rightBalancedDrug metabolismHuman-GEM MAR12862
chloride[e] + Torasemide-M5[c] = chloride[c] + Torasemide-M5[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12863
O2[r] + Torasemide-M1[r] = H+[r] + H2O[r] + Torasemide-M5[r]
Left to rightBalancedEC 1.14.13.-Drug metabolismHuman-GEM MAR12864
HCO3-[c] + Torasemide[e] = HCO3-[e] + Torasemide[c]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12865
chloride[e] + Torasemide[c] = chloride[c] + Torasemide[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12866
AKG[c] + Na+[e] + Torasemide[e] = AKG[e] + Na+[c] + Torasemide[c]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12867
Torasemide[e] = Torasemide[c]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12868
2 H+[r] + 2 NADPH[r] + 2 O2[r] + pravastatin[r] = H2O2[r] + 2 NADP+[r] + triol metabolite of pravastatin[r]
Left to rightBalancedEC 1.14.13.-Drug metabolismHuman-GEM MAR12869
ATP[c] + H2O[c] + triol metabolite of pravastatin[c] = ADP[c] + H+[c] + Pi[c] + triol metabolite of pravastatin[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12870
triol metabolite of pravastatin[c] = triol metabolite of pravastatin[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12871
ATP[c] + H2O[c] + thiomethyl-sulphoxide-acetaminophen-glucuronide[c] = ADP[c] + H+[c] + Pi[c] + thiomethyl-sulphoxide-acetaminophen-glucuronide[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12872
UDP-glucuronate[r] + thiomethyl-sulphoxide-conjugate-acetaminophen[r] = H+[r] + UDP[r] + thiomethyl-sulphoxide-acetaminophen-glucuronide[r]
Left to rightBalancedDrug metabolismHuman-GEM MAR12873
PAPS[c] + thiomethyl-sulphoxide-conjugate-acetaminophen[c] = H+[c] + PAP[c] + thiomethyl-sulphoxide-acetaminophen-sulphate[c]
Left to rightBalancedDrug metabolismHuman-GEM MAR12874
ATP[c] + H2O[c] + thiomethyl-sulphoxide-acetaminophen-sulphate[c] = ADP[c] + H+[c] + Pi[c] + thiomethyl-sulphoxide-acetaminophen-sulphate[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12875
12-HT or M-VI, 12-hydroxy tacrolimus[r] = 12-HT or M-VI, 12-hydroxy tacrolimus[c]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12876
13,31-O-Didesmethyl-tacrolimus[r] = 13,31-O-Didesmethyl-tacrolimus[c]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12877
1,4-Dihydroxy-midazolam[r] = 1,4-Dihydroxy-midazolam[c]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12878
13,15-O-didesmethyl tacrolimus[r] = 13,15-O-didesmethyl tacrolimus[c]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12879
15,31-O-Didesmethyl-tacrolimus[r] = 15,31-O-Didesmethyl-tacrolimus[c]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12880
1-hydroxy S-ibuprofen[r] = 1-hydroxy S-ibuprofen[c]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12881
1-hydroxy S-ibuprofen-glucuronide[r] = 1-hydroxy S-ibuprofen-glucuronide[c]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12882
1'-OH-midazolam-glucuronide[r] = 1'-OH-midazolam-glucuronide[c]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12883
2-hydroxy-atorvastatin-acyl-glucuronide[r] = 2-hydroxy-atorvastatin-acyl-glucuronide[c]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12884
2-hydroxy-atorvastatin-lactone-glucuronide[r] = 2-hydroxy-atorvastatin-lactone-glucuronide[c]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12885
2-hydroxy-R-ibuprofen[r] = 2-hydroxy-R-ibuprofen[c]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12886
2-hydroxy-S-ibuprofen[r] = 2-hydroxy-S-ibuprofen[c]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12887
2-hydroxy S-ibuprofen-glucuronide[r] = 2-hydroxy S-ibuprofen-glucuronide[c]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12888
3'-alpha,5'beta-dihydroxy-pravastatin / 3'-alpha5'beta6'beta-trihydroxy pravastatin[r] = 3'-alpha,5'beta-dihydroxy-pravastatin / 3'-alpha5'beta6'beta-trihydroxy pravastatin[c]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12889