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12,401–12,450 of 12,877 reactions from Human-GEM
H+[r] + NADPH[r] + O2[r] + Gliclazide[r] = H2O[r] + NADP+[r] + Methyl-hydroxy-gliclazide[r]
Left to rightBalancedEC 1.14.13.-, 1.14.14.1Drug metabolismHuman-GEM MAR12790
Methyl-hydroxy-gliclazide[c] = Methyl-hydroxy-gliclazide[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12791
H+[r] + NADPH[r] + O2[r] + 2 SAH[r] + rosuvastatin[r] = H2O2[r] + NADP+[r] + 2 SAM[r] + N-desmethyl-rosuvastatin[r]
Left to rightBalancedEC 1.14.13.-Drug metabolismHuman-GEM MAR12792
ATP[c] + H2O[c] + N-desmethyl-rosuvastatin[c] = ADP[c] + H+[c] + Pi[c] + N-desmethyl-rosuvastatin[e]
Left to rightBalancedTransportEC 7.6.2.2Drug metabolismHuman-GEM MAR12793
H+[r] + NADPH[r] + O2[r] + acid metabolite of nifedipine[r] = H2O[r] + NADP+[r] + hydroxy metabolite of nifedipine[r]
Left to rightBalancedEC 1.14.13.-, 1.14.14.1Drug metabolismHuman-GEM MAR12794
acid metabolite of nifedipine[c] = acid metabolite of nifedipine[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12795
SAH[r] + Nitropyridine metabolite of nifedipine[r] = SAM[r] + acid metabolite of nifedipine[r]
Left to rightBalancedDrug metabolismHuman-GEM MAR12796
H+[c] + hydroxy metabolite of nifedipine[c] = H2O[c] + lactone form of nifedipine[c]
ReversibleBalancedDrug metabolismHuman-GEM MAR12797
lactone form of nifedipine[c] = lactone form of nifedipine[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12798
Nitropyridine metabolite of nifedipine[c] = Nitropyridine metabolite of nifedipine[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12799
hydroxy metabolite of nifedipine[c] = hydroxy metabolite of nifedipine[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12800
NADP+[c] + nifedipine[c] = H+[c] + NADPH[c] + Nitropyridine metabolite of nifedipine[c]
Left to rightBalancedDrug metabolismHuman-GEM MAR12801
oxypurinol[c] + udp-ribose[c] = H+[c] + UDP[c] + oxypurinol-1-riboside[c]
Left to rightBalancedDrug metabolismHuman-GEM MAR12802
oxypurinol[c] + udp-ribose[c] = H+[c] + UDP[c] + oxypurinol-7-riboside[c]
Left to rightBalancedDrug metabolismHuman-GEM MAR12803
oxypurinol-1-riboside[c] = oxypurinol-1-riboside[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12804
oxypurinol-7-riboside[c] = oxypurinol-7-riboside[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12805
oxypurinol[e] = oxypurinol[c]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12806
H+[c] + oxypurinol[c] = H+[e] + oxypurinol[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12807
4 CoA[x] + 2 FAD[x] + 2 H2O[x] + 4 NAD+[x] + NADPH[x] + fluvastatin-CoA form[x] = 4 acetyl-CoA[x] + 2 FADH2[x] + 3 H+[x] + 4 NADH[x] + NADP+[x] + des-isoproylpropionic-acid-fluvastatin-CoA[x]
Left to rightBalancedEC 1.3.3.6, 4.2.1.17, 1.1.1.35, 2.3.1.16, 1.14.13.-Drug metabolismHuman-GEM MAR12808
H2O[c] + 2 SAM[c] + des-isoproylpropionic-acid-fluvastatin-CoA[c] = CoA[c] + 2 H+[c] + 2 SAH[c] + des-isoproylpropionic-acid-fluvastatin[c]
Left to rightBalancedDrug metabolismHuman-GEM MAR12809
des-isoproylpropionic-acid-fluvastatin[c] = des-isoproylpropionic-acid-fluvastatin[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12810
ATP[c] + H2O[c] + pitavastatin[c] = ADP[c] + H+[c] + Pi[c] + pitavastatin[e]
Left to rightBalancedTransportEC 7.6.2.2Drug metabolismHuman-GEM MAR12811
2 UDP-glucuronate[r] + pitavastatin[r] = 2 UDP[r] + pitavastatin-glucuronide[r]
Left to rightBalancedEC 2.4.1.17Drug metabolismHuman-GEM MAR12812
pitavastatin-glucuronide[r] = 2 glucuronate[r] + pitavastatin-lactone[r]
Left to rightBalancedDrug metabolismHuman-GEM MAR12813
pitavastatin-lactone[c] = pitavastatin-lactone[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12814
H+[r] + NADPH[r] + 2 O2[r] + pitavastatin[r] = H2O2[r] + NADP+[r] + pitavastatin-M13[r]
Left to rightBalancedEC 1.14.13.-, 1.14.14.1Drug metabolismHuman-GEM MAR12815
ATP[c] + H2O[c] + pitavastatin-M3[c] = ADP[c] + H+[c] + Pi[c] + pitavastatin-M3[e]
Left to rightBalancedTransportEC 7.6.2.2Drug metabolismHuman-GEM MAR12816
O2[r] + pitavastatin[r] = 2 H2O[r] + pitavastatin-M3[r]
Left to rightBalancedEC 1.14.13.-Drug metabolismHuman-GEM MAR12817
2 H2O[r] + pitavastatin-lactone[r] = 2 H+[r] + pitavastatin[r]
Left to rightBalancedEC 3.1.1.2Drug metabolismHuman-GEM MAR12818
pitavastatin[c] = pitavastatin[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12819
HCO3-[c] + pitavastatin[e] = HCO3-[e] + pitavastatin[c]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12820
ATP[c] + H2O[c] + pravastatin[c] = ADP[c] + H+[c] + Pi[c] + pravastatin[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12821
UDP-glucuronate[r] + pravastatin[r] = H+[r] + UDP[r] + pravastatin glucuronide[r]
Left to rightBalancedDrug metabolismHuman-GEM MAR12822
ATP[c] + H2O[c] + pravastatin glucuronide[c] = ADP[c] + H+[c] + Pi[c] + pravastatin glucuronide[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12823
pravastatin glucuronide[c] = pravastatin glucuronide[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12824
H+[e] + pravastatin[e] = H+[c] + pravastatin[c]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12825
HCO3-[c] + pravastatin[e] = HCO3-[e] + pravastatin[c]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12826
pravastatin[c] = pravastatin[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12827
ATP[c] + H2O[c] + rosuvastatin[c] = ADP[c] + H+[c] + Pi[c] + rosuvastatin[e]
Left to rightBalancedTransportEC 7.6.2.2Drug metabolismHuman-GEM MAR12828
2 UDP-glucuronate[r] + rosuvastatin[r] = 2 UDP[r] + rosuvastatin-glucuronide[r]
Left to rightBalancedDrug metabolismHuman-GEM MAR12829
rosuvastatin-glucuronide[r] = 2 glucuronate[r] + rosuvastatin-5S-lactone[r]
Left to rightBalancedDrug metabolismHuman-GEM MAR12830
ATP[c] + H2O[c] + rosuvastatin-5S-lactone[c] = ADP[c] + H+[c] + Pi[c] + rosuvastatin-5S-lactone[e]
Left to rightBalancedTransportEC 7.6.2.2Drug metabolismHuman-GEM MAR12831
2 H2O[c] + rosuvastatin-5S-lactone[c] = 2 H+[c] + rosuvastatin[c]
Left to rightBalancedEC 3.1.1.81Drug metabolismHuman-GEM MAR12832
2 H2O[r] + rosuvastatin-glucuronide[r] = 2 glucuronate[r] + 2 H+[r] + rosuvastatin[r]
Left to rightBalancedDrug metabolismHuman-GEM MAR12833
rosuvastatin[c] = rosuvastatin[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12834
HCO3-[c] + rosuvastatin[e] = HCO3-[e] + rosuvastatin[c]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12835
PAPS[c] + SAH[c] + 3-methoxy-acetaminophen[c] = PAP[c] + SAM[c] + sulphate-conjugate-3-methoxy-acetaminophen[c]
Left to rightBalancedDrug metabolismHuman-GEM MAR12836
ATP[c] + H2O[c] + sulphate-conjugate-3-methoxy-acetaminophen[c] = ADP[c] + H+[c] + Pi[c] + sulphate-conjugate-3-methoxy-acetaminophen[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12837
ATP[c] + H2O[c] + simvastatin dihydroxy acid form[c] = ADP[c] + H+[c] + Pi[c] + simvastatin dihydroxy acid form[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12838
H2O[r] + simvastatin-acyl-glucuronide[r] = glucuronate[r] + H+[r] + simvastatin dihydroxy acid form[r]
Left to rightBalancedEC 3.2.1.31Drug metabolismHuman-GEM MAR12839