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12,151–12,200 of 12,877 reactions from Human-GEM
H2O[r] + cerivastatin-M1-glucuronide[r] = glucuronate[r] + cerivastatin-M1[r]
Left to rightBalancedEC 3.2.1.31Drug metabolismHuman-GEM MAR12540
ATP[c] + H2O[c] + cerivastatin-M1[c] = ADP[c] + H+[c] + Pi[c] + cerivastatin-M1[e]
Left to rightBalancedTransportEC 7.6.2.2Drug metabolismHuman-GEM MAR12541
SAM[r] + cerivastatin-M1-glucuronide[r] = glucuronate[r] + H+[r] + SAH[r] + cerivastatin-M22[r]
Left to rightBalancedDrug metabolismHuman-GEM MAR12542
H+[r] + NADPH[r] + O2[r] + cerivastatin[r] = H2O[r] + NADP+[r] + cerivastatin-M23[r]
Left to rightBalancedEC 1.14.14.1Drug metabolismHuman-GEM MAR12543
H2O[r] + cerivastatin-M23-glucuronide[r] = glucuronate[r] + cerivastatin-M23[r]
Left to rightBalancedEC 3.2.1.31Drug metabolismHuman-GEM MAR12544
ATP[c] + H2O[c] + cerivastatin-M23[c] = ADP[c] + H+[c] + Pi[c] + cerivastatin-M23[e]
Left to rightBalancedTransportEC 7.6.2.2Drug metabolismHuman-GEM MAR12545
cerivastatin-M23[c] = cerivastatin-M23[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12546
ATP[c] + H2O[c] + cerivastatin-M24[c] = ADP[c] + H+[c] + Pi[c] + cerivastatin-M24[e]
Left to rightBalancedTransportEC 7.6.2.2Drug metabolismHuman-GEM MAR12547
cerivastatin-M24[c] = cerivastatin-M24[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12548
SAM[r] + cerivastatin-M23-glucuronide[r] = glucuronate[r] + H+[r] + SAH[r] + cerivastatin-M31[r]
Left to rightBalancedDrug metabolismHuman-GEM MAR12549
cerivastatin[e] = cerivastatin[c]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12550
HCO3-[c] + cerivastatin[e] = HCO3-[e] + cerivastatin[c]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12551
PAPS[c] + cyclosporine[c] = H+[c] + PAP[c] + cyclosporine-sulphate[c]
Left to rightBalancedDrug metabolismHuman-GEM MAR12552
ATP[c] + H2O[c] + cyclosporine-sulphate[c] = ADP[c] + H+[c] + Pi[c] + cyclosporine-sulphate[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12553
cyclosporine-sulphate[c] = cyclosporine-sulphate[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12554
cyclosporine[e] = cyclosporine[c]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12555
ATP[c] + H2O[c] + cyclosporine[c] = ADP[c] + H+[c] + Pi[c] + cyclosporine[e]
Left to rightBalancedTransportEC 7.6.2.2Drug metabolismHuman-GEM MAR12556
UDP-glucuronate[r] + cerivastatin-M1[r] = H+[r] + UDP[r] + cerivastatin-M1-glucuronide[r]
Left to rightBalancedEC 2.4.1.17Drug metabolismHuman-GEM MAR12557
UDP-glucuronate[r] + cerivastatin-M23[r] = H+[r] + UDP[r] + cerivastatin-M23-glucuronide[r]
Left to rightBalancedEC 2.4.1.17Drug metabolismHuman-GEM MAR12558
acetyl-CoA[c] + cysteine-conjugate-acetaminophen[c] = CoA[c] + H+[c] + acetaminophen-mercapturate-conjugate/N-acetyl-cysteine-acetaminophen[c]
Left to rightBalancedDrug metabolismHuman-GEM MAR12559
ATP[c] + H2O[c] + cysteine-conjugate-acetaminophen[c] = ADP[c] + H+[c] + Pi[c] + cysteine-conjugate-acetaminophen[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12560
H+[c] + H2O[c] + SAH[c] + cerivastatin-M31[c] = SAM[c] + cerivastatin-M23[c]
Left to rightBalancedDrug metabolismHuman-GEM MAR12561
CoA[x] + H2O[x] + NAD+[x] + fluvastatin[x] = acetyl-CoA[x] + H+[x] + H2O2[x] + NADH[x] + deoxy-fluvastatin-dinor[x]
Left to rightBalancedEC 1.3.3.6, 4.2.1.17, 1.1.1.35, 2.3.1.16Drug metabolismHuman-GEM MAR12562
deoxy-fluvastatin-dinor[c] = deoxy-fluvastatin-dinor[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12563
4 H+[r] + NADPH[r] + O2[r] + 3 SAH[r] + fluvastatin[r] = H2O2[r] + NADP+[r] + 3 SAM[r] + N-desisopropyl-fluvastatin[r]
Left to rightBalancedEC 1.14.13.-Drug metabolismHuman-GEM MAR12564
ATP[c] + H2O[c] + N-desisopropyl-fluvastatin[c] = ADP[c] + H+[c] + Pi[c] + N-desisopropyl-fluvastatin[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12565
ATP[c] + H2O[c] + dehydro-gliclazide[c] = ADP[c] + H+[c] + Pi[c] + dehydro-gliclazide[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12566
NADP+[c] + Gliclazide[c] = H+[c] + NADPH[c] + dehydro-gliclazide[c]
Left to rightBalancedDrug metabolismHuman-GEM MAR12567
dehydro-gliclazide[c] = dehydro-gliclazide[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12568
6 H+[r] + NADPH[r] + 5 SAH[r] + pravastatin[r] = 2 H2O[r] + NADP+[r] + 5 SAM[r] + desacyl dehydro-pravastatin[r]
Left to rightBalancedEC 1.14.13.-Drug metabolismHuman-GEM MAR12569
ATP[c] + H2O[c] + desacyl dehydro-pravastatin[c] = ADP[c] + H+[c] + Pi[c] + desacyl dehydro-pravastatin[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12570
desacyl dehydro-pravastatin[c] = desacyl dehydro-pravastatin[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12571
3 H+[r] + O2[r] + 3 SAH[r] + Tacrolimus[r] = 3 SAM[r] + 31-O-Desmethyl,19-Hydroxy,37, 39-Epoxy-tacrolimus[r]
Left to rightBalancedDrug metabolismHuman-GEM MAR12572
ATP[c] + H2O[c] + 31-O-Desmethyl,19-Hydroxy,37, 39-Epoxy-tacrolimus[c] = ADP[c] + H+[c] + Pi[c] + 31-O-Desmethyl,19-Hydroxy,37, 39-Epoxy-tacrolimus[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12573
31-O-Desmethyl,19-Hydroxy,37, 39-Epoxy-tacrolimus[c] = 31-O-Desmethyl,19-Hydroxy,37, 39-Epoxy-tacrolimus[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12574
12-HT or M-VI, 12-hydroxy tacrolimus[e] =
ReversibleBalance undeterminableExchange/demand reactionsHuman-GEM MAR12575
13,31-O-Didesmethyl-tacrolimus[e] =
ReversibleBalance undeterminableExchange/demand reactionsHuman-GEM MAR12576
13-O-desmethyl tacrolimus, 13-DMT or M-I[e] =
ReversibleBalance undeterminableExchange/demand reactionsHuman-GEM MAR12577
1,4-Dihydroxy-midazolam[e] =
ReversibleBalance undeterminableExchange/demand reactionsHuman-GEM MAR12578
13,15-O-didesmethyl tacrolimus[e] =
ReversibleBalance undeterminableExchange/demand reactionsHuman-GEM MAR12579
15,31-O-Didesmethyl-tacrolimus[e] =
ReversibleBalance undeterminableExchange/demand reactionsHuman-GEM MAR12580
15-DMT or M-III, 15-O-desmethyl tacrolimus[e] =
ReversibleBalance undeterminableExchange/demand reactionsHuman-GEM MAR12581
1-hydroxy S-ibuprofen[e] =
ReversibleBalance undeterminableExchange/demand reactionsHuman-GEM MAR12582
1-hydroxy S-ibuprofen-glucuronide[e] =
ReversibleBalance undeterminableExchange/demand reactionsHuman-GEM MAR12583
1'-OH-midazolam-glucuronide[e] =
ReversibleBalance undeterminableExchange/demand reactionsHuman-GEM MAR12584
1'-OH-midazolam[e] =
ReversibleBalance undeterminableExchange/demand reactionsHuman-GEM MAR12585
2-hydroxy-atorvastatin-acid / ortho-hydroxy-atorvastatin acid[e] =
ReversibleBalance undeterminableExchange/demand reactionsHuman-GEM MAR12586
2-hydroxy-atorvastatin-acyl-glucuronide[e] =
ReversibleBalance undeterminableExchange/demand reactionsHuman-GEM MAR12587
2-hydroxy-atorvastatin-lactone / ortho-hydroxy-atorvastatin lactone[e] =
ReversibleBalance undeterminableExchange/demand reactionsHuman-GEM MAR12588
2-hydroxy-atorvastatin-lactone-glucuronide[e] =
ReversibleBalance undeterminableExchange/demand reactionsHuman-GEM MAR12589