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12,101–12,150 of 12,877 reactions from Human-GEM
ATP[c] + H2O[c] + AM1c9 (cyclosporine)[c] = ADP[c] + H+[c] + Pi[c] + AM1c9 (cyclosporine)[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12490
AM1c9 (cyclosporine)[c] = AM1c9 (cyclosporine)[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12491
H+[r] + NADPH[r] + O2[r] + cyclosporine[r] = H2O[r] + NADP+[r] + AM1c (cyclosporine)[r]
Left to rightBalancedDrug metabolismHuman-GEM MAR12492
ATP[c] + H2O[c] + AM1c (cyclosporine)[c] = ADP[c] + H+[c] + Pi[c] + AM1c (cyclosporine)[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12493
AM1c (cyclosporine)[c] = AM1c (cyclosporine)[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12494
UDP-glucuronate[r] + AM1c (cyclosporine)[r] = H+[r] + UDP[r] + AM1c-glucuronide (cyclosporine)[r]
Left to rightBalancedDrug metabolismHuman-GEM MAR12495
ATP[c] + H2O[c] + AM1c-glucuronide (cyclosporine)[c] = ADP[c] + H+[c] + Pi[c] + AM1c-glucuronide (cyclosporine)[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12496
H+[r] + NADPH[r] + O2[r] + cyclosporine[r] = H2O[r] + NADP+[r] + AM1 (cyclosporine)[r]
Left to rightBalancedEC 1.14.13.-, 1.14.14.1Drug metabolismHuman-GEM MAR12497
AM1 (cyclosporine)[c] = AM1 (cyclosporine)[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12498
H+[c] + SAH[c] + AM9 (cyclosporine)[c] = SAM[c] + AM4N9 (cyclosporine)[c]
Left to rightBalancedDrug metabolismHuman-GEM MAR12499
H+[r] + NADPH[r] + O2[r] + AM4N (cyclosporine)[r] = H2O[r] + NADP+[r] + AM4N9 (cyclosporine)[r]
Left to rightBalancedDrug metabolismHuman-GEM MAR12500
AM4N9 (cyclosporine)[c] = AM4N9 (cyclosporine)[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12501
ATP[c] + H2O[c] + AM4N9 (cyclosporine)[c] = ADP[c] + H+[c] + Pi[c] + AM4N9 (cyclosporine)[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12502
H+[c] + SAH[c] + cyclosporine[c] = SAM[c] + AM4N (cyclosporine)[c]
Left to rightBalancedDrug metabolismHuman-GEM MAR12503
ATP[c] + H2O[c] + AM4N (cyclosporine)[c] = ADP[c] + H+[c] + Pi[c] + AM4N (cyclosporine)[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12504
AM4N (cyclosporine)[c] = AM4N (cyclosporine)[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12505
H+[r] + NADPH[r] + O2[r] + cyclosporine[r] = H2O[r] + NADP+[r] + AM9 (cyclosporine)[r]
Left to rightBalancedEC 1.14.13.-, 1.14.14.1Drug metabolismHuman-GEM MAR12506
ATP[c] + H2O[c] + AM9 (cyclosporine)[c] = ADP[c] + H+[c] + Pi[c] + AM9 (cyclosporine)[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12507
AM9 (cyclosporine)[c] = AM9 (cyclosporine)[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12508
H+[e] + atorvastatin-acid[e] = H+[c] + atorvastatin-acid[c]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12509
HCO3-[c] + atorvastatin-acid[e] = HCO3-[e] + atorvastatin-acid[c]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12510
H2O[c] + atorvastatin-lactone[c] = H+[c] + atorvastatin-acid[c]
Left to rightBalancedEC 3.1.1.2Drug metabolismHuman-GEM MAR12511
2 H2O[r] + atorvastatin-ether-glucuronide -G1[r] = 2 glucuronate[r] + atorvastatin-acid[r]
Left to rightBalancedDrug metabolismHuman-GEM MAR12512
atorvastatin-acid[e] = atorvastatin-acid[c]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12513
ATP[c] + H2O[c] + atorvastatin-acid[c] = ADP[c] + H+[c] + Pi[c] + atorvastatin-acid[e]
Left to rightBalancedTransportEC 7.6.2.2Drug metabolismHuman-GEM MAR12514
UDP-glucuronate[r] + atorvastatin-acid[r] = UDP[r] + atorvastatin-acyl-glucuronide / G2[r]
Left to rightBalancedEC 2.4.1.17Drug metabolismHuman-GEM MAR12515
2 UDP-glucuronate[r] + atorvastatin-acid[r] = 2 H+[r] + 2 UDP[r] + atorvastatin-ether-glucuronide -G1[r]
Left to rightBalancedEC 2.4.1.17Drug metabolismHuman-GEM MAR12516
UDP-glucuronate[r] + atorvastatin-lactone[r] = H+[r] + UDP[r] + atorvastatin-lactone-ether-glucuronide / G3[r]
Left to rightBalancedEC 2.4.1.17Drug metabolismHuman-GEM MAR12517
HCO3-[c] + atorvastatin-lactone[e] = HCO3-[e] + atorvastatin-lactone[c]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12518
atorvastatin-acyl-glucuronide / G2[r] = glucuronate[r] + atorvastatin-lactone[r]
Left to rightBalancedDrug metabolismHuman-GEM MAR12519
ATP[c] + atorvastatin-acid[c] = AMP[c] + PPi[c] + atorvastatin-lactone[c]
Left to rightBalancedDrug metabolismHuman-GEM MAR12520
H2O[r] + atorvastatin-lactone-ether-glucuronide / G3[r] = glucuronate[r] + atorvastatin-lactone[r]
Left to rightBalancedDrug metabolismHuman-GEM MAR12521
atorvastatin-lactone[e] = atorvastatin-lactone[c]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12522
ATP[c] + H2O[c] + atorvastatin-lactone[c] = ADP[c] + H+[c] + Pi[c] + atorvastatin-lactone[e]
Left to rightBalancedTransportEC 7.6.2.2Drug metabolismHuman-GEM MAR12523
AM19 (cyclosporine)[c] = AM19 (cyclosporine)[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12524
ATP[c] + H2O[c] + AM1 (cyclosporine)[c] = ADP[c] + H+[c] + Pi[c] + AM1 (cyclosporine)[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12525
S-carboxy ibuprofen glucuronide[c] = S-carboxy ibuprofen glucuronide[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12526
R-carboxy ibuprofen[c] = R-carboxy ibuprofen[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12527
UDP-glucuronate[r] + S-carboxy ibuprofen[r] = UDP[r] + S-carboxy ibuprofen glucuronide[r]
Left to rightBalancedEC 2.4.1.17Drug metabolismHuman-GEM MAR12528
S-carboxy ibuprofen[c] = S-carboxy ibuprofen[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12529
ATP[c] + H2O[c] + carboxy-gliclazide[c] = ADP[c] + H+[c] + Pi[c] + carboxy-gliclazide[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12530
O2[r] + Methyl-hydroxy-gliclazide[r] = H+[r] + H2O[r] + carboxy-gliclazide[r]
Left to rightBalancedDrug metabolismHuman-GEM MAR12531
carboxy-gliclazide[c] = carboxy-gliclazide[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12532
H+[r] + NADPH[r] + O2[r] + cerivastatin-M1[r] = H2O[r] + NADP+[r] + cerivastatin-M24[r]
Left to rightBalancedEC 1.14.14.1, 1.14.13.-Drug metabolismHuman-GEM MAR12533
cerivastatin-M1[c] = cerivastatin-M1[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12534
2 H+[r] + NADPH[r] + O2[r] + SAH[r] + cerivastatin-M23[r] = H2O2[r] + NADP+[r] + SAM[r] + cerivastatin-M24[r]
Left to rightBalancedEC 1.14.14.1, 1.14.13.-Drug metabolismHuman-GEM MAR12535
ATP[c] + H2O[c] + cerivastatin[e] = ADP[c] + H+[c] + Pi[c] + cerivastatin[c]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12536
ATP[c] + H2O[c] + cerivastatin[c] = ADP[c] + H+[c] + Pi[c] + cerivastatin[e]
Left to rightBalancedTransportEC 7.6.2.2Drug metabolismHuman-GEM MAR12537
H+[c] + H2O[c] + SAH[c] + cerivastatin-M22[c] = SAM[c] + cerivastatin-M1[c]
Left to rightBalancedDrug metabolismHuman-GEM MAR12538
2 H+[r] + NADPH[r] + O2[r] + SAH[r] + cerivastatin[r] = H2O2[r] + NADP+[r] + SAM[r] + cerivastatin-M1[r]
Left to rightBalancedEC 1.14.14.1, 1.14.13.-Drug metabolismHuman-GEM MAR12539