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12,051–12,100 of 12,877 reactions from Human-GEM
H2O[c] + 6'-exomethylene-lovastatin lactone form[c] = H+[c] + 6'-exomethylene-lovastatin-acid form[c]
Left to rightBalancedEC 3.1.1.2Drug metabolismHuman-GEM MAR12440
ATP[c] + H2O[c] + 6'-exomethylene-lovastatin-acid form[c] = ADP[c] + H+[c] + Pi[c] + 6'-exomethylene-lovastatin-acid form[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12441
6'-exomethylene-lovastatin lactone form[e] = 6'-exomethylene-lovastatin lactone form[c]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12442
H+[r] + NADPH[r] + O2[r] + simvastatin lactone form[r] = 2 H2O[r] + NADP+[r] + 6'-exomethylene-simvastatin-lactone form[r]
Left to rightBalancedEC 1.14.13.-, 1.14.14.1Drug metabolism
UDP-glucuronate[r] + 5-hydroxy-fluvastatin[r] = H+[r] + UDP[r] + 6-hydroxy-fluvastatin-glucuronide[r]
Left to rightBalancedDrug metabolismHuman-GEM MAR12444
6-hydroxy-fluvastatin-glucuronide[c] = 6-hydroxy-fluvastatin-glucuronide[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12445
H+[r] + NADPH[r] + O2[r] + fluvastatin[r] = H2O[r] + NADP+[r] + 6-hydroxy-fluvastatin[r]
Left to rightBalancedEC 1.14.13.-Drug metabolismHuman-GEM MAR12446
ATP[c] + H2O[c] + 6-hydroxy-fluvastatin[c] = ADP[c] + H+[c] + Pi[c] + 6-hydroxy-fluvastatin[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12447
ATP[c] + H2O[c] + 7-alpha-OH-gliclazide[c] = ADP[c] + H+[c] + Pi[c] + 7-alpha-OH-gliclazide[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12448
H+[r] + NADPH[r] + O2[r] + Gliclazide[r] = H2O[r] + NADP+[r] + 7-alpha-OH-gliclazide[r]
Left to rightBalancedDrug metabolismHuman-GEM MAR12449
7-alpha-OH-gliclazide[c] = 7-alpha-OH-gliclazide[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12450
ATP[c] + H2O[c] + 7-beta-OH-gliclazide[c] = ADP[c] + H+[c] + Pi[c] + 7-beta-OH-gliclazide[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12451
ATP[c] + H2O[c] + 7-beta-OH-gliclazide-glucuronide[c] = ADP[c] + H+[c] + Pi[c] + 7-beta-OH-gliclazide-glucuronide[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12452
UDP-glucuronate[r] + 7-beta-OH-gliclazide[r] = H+[r] + UDP[r] + 7-beta-OH-gliclazide-glucuronide[r]
Left to rightBalancedDrug metabolismHuman-GEM MAR12453
7-beta-OH-gliclazide-glucuronide[c] = 7-beta-OH-gliclazide-glucuronide[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12454
H+[r] + NADPH[r] + O2[r] + Gliclazide[r] = H2O[r] + NADP+[r] + 7-beta-OH-gliclazide[r]
Left to rightBalancedEC 1.14.13.-, 1.14.14.1Drug metabolismHuman-GEM MAR12455
7-beta-OH-gliclazide[c] = 7-beta-OH-gliclazide[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12456
H+[r] + NADPH[r] + O2[r] + 3-alpha-iso-pravastatin[r] = H2O[r] + NADP+[r] + 7-hydroxy-3-alpha-iso-pravastatin[r]
Left to rightBalancedEC 1.14.13.-Drug metabolismHuman-GEM MAR12457
ATP[c] + H2O[c] + 7-hydroxy-3-alpha-iso-pravastatin[c] = ADP[c] + H+[c] + Pi[c] + 7-hydroxy-3-alpha-iso-pravastatin[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12458
7-hydroxy-3-alpha-iso-pravastatin[c] = 7-hydroxy-3-alpha-iso-pravastatin[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12459
H+[e] + allopurinol[e] = H+[c] + allopurinol[c]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12460
ATP[c] + H2O[c] + acetaminophen/paracetamol[c] = ADP[c] + H+[c] + Pi[c] + acetaminophen/paracetamol[e]
Left to rightBalancedTransportEC 7.6.2.2Drug metabolismHuman-GEM MAR12461
UDP-glucuronate[r] + acetaminophen/paracetamol[r] = H+[r] + UDP[r] + Acetaminophen glucuronide[r]
Left to rightBalancedEC 2.4.1.17Drug metabolismHuman-GEM MAR12462
acetaminophen-glutathione-conjugate[e] = acetaminophen-glutathione-conjugate[c]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12463
ATP[c] + H2O[c] + acetaminophen-glutathione-conjugate[c] = ADP[c] + H+[c] + Pi[c] + acetaminophen-glutathione-conjugate[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12464
ATP[c] + H2O[c] + acetaminophen-glutathione-conjugate[e] = ADP[c] + H+[c] + Pi[c] + acetaminophen-glutathione-conjugate[c]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12465
ATP[c] + H2O[c] + Acetaminophen glucuronide[c] = ADP[c] + H+[c] + Pi[c] + Acetaminophen glucuronide[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12466
ATP[c] + H2O[c] + Acetaminophen glucuronide[e] = ADP[c] + H+[c] + Pi[c] + Acetaminophen glucuronide[c]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12467
PAPS[c] + acetaminophen/paracetamol[c] = H+[c] + PAP[c] + sulphate-conjugate-acetaminophen[c]
Left to rightBalancedEC 2.8.2.1Drug metabolismHuman-GEM MAR12468
acetaminophen/paracetamol[e] = acetaminophen/paracetamol[c]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12469
ATP[c] + H2O[c] + acetaminophen/paracetamol[e] = ADP[c] + H+[c] + Pi[c] + acetaminophen/paracetamol[c]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12470
Na+[e] + allopurinol[e] = Na+[c] + allopurinol[c]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12471
H2O[c] + O2[c] + allopurinol[c] = H2O2[c] + oxypurinol[c]
Left to rightBalancedEC 1.17.3.2, 1.2.3.1Drug metabolismHuman-GEM MAR12472
allopurinol[e] = allopurinol[c]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12473
H+[r] + NADPH[r] + O2[r] + AM1 (cyclosporine)[r] = H2O[r] + NADP+[r] + AM19 (cyclosporine)[r]
Left to rightBalancedEC 1.14.13.-, 1.14.14.1Drug metabolismHuman-GEM MAR12474
H+[r] + NADPH[r] + O2[r] + AM9 (cyclosporine)[r] = H2O[r] + NADP+[r] + AM19 (cyclosporine)[r]
Left to rightBalancedDrug metabolismHuman-GEM MAR12475
ATP[c] + H2O[c] + AM19 (cyclosporine)[c] = ADP[c] + H+[c] + Pi[c] + AM19 (cyclosporine)[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12476
H+[c] + SAH[c] + AM1A (cyclosporine)[c] = SAM[c] + AM1A4N (cyclosporine)[c]
Left to rightBalancedDrug metabolismHuman-GEM MAR12477
ATP[c] + H2O[c] + AM1A4N (cyclosporine)[c] = ADP[c] + H+[c] + Pi[c] + AM1A4N (cyclosporine)[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12478
O2[r] + AM1c (cyclosporine)[r] = H+[r] + H2O[r] + AM1Ac (cyclosporine)[r]
Left to rightBalancedDrug metabolismHuman-GEM MAR12479
AM1Ac (cyclosporine)[c] = AM1Ac (cyclosporine)[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12480
NADPH[r] + O2[r] + AM1AL (cyclosporine)[r] = H2O[r] + NADP+[r] + AM1A (cyclosporine)[r]
Left to rightBalancedDrug metabolismHuman-GEM MAR12481
ATP[c] + H2O[c] + AM1A (cyclosporine)[c] = ADP[c] + H+[c] + Pi[c] + AM1A (cyclosporine)[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12482
AM1A (cyclosporine)[c] = AM1A (cyclosporine)[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12483
NADP+[c] + AM1 (cyclosporine)[c] = H+[c] + NADPH[c] + AM1AL (cyclosporine)[c]
Left to rightBalancedDrug metabolismHuman-GEM MAR12484
ATP[c] + H2O[c] + AM1AL (cyclosporine)[c] = ADP[c] + H+[c] + Pi[c] + AM1AL (cyclosporine)[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12485
AM1AL (cyclosporine)[c] = AM1AL (cyclosporine)[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12486
H+[c] + SAH[c] + AM1c9 (cyclosporine)[c] = SAM[c] + AM1c4N9 (cyclosporine)[c]
Left to rightBalancedDrug metabolismHuman-GEM MAR12487
ATP[c] + H2O[c] + AM1c4N9 (cyclosporine)[c] = ADP[c] + H+[c] + Pi[c] + AM1c4N9 (cyclosporine)[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12488
H+[r] + NADPH[r] + O2[r] + AM1c (cyclosporine)[r] = H2O[r] + NADP+[r] + AM1c9 (cyclosporine)[r]
Left to rightBalancedDrug metabolismHuman-GEM MAR12489