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12,001–12,050 of 12,877 reactions from Human-GEM
H+[r] + NADPH[r] + O2[r] + Gliclazide[r] = H2O[r] + NADP+[r] + 4-beta-OH-gliclazide[r]
Left to rightBalancedDrug metabolismHuman-GEM MAR12390
4-beta-OH-gliclazide[c] = 4-beta-OH-gliclazide[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12391
H+[r] + NADPH[r] + O2[r] + atorvastatin-acid[r] = H2O[r] + NADP+[r] + 4-hydroxy-atorvastatin-acid / para-hydroxy-atorvastatin acid[r]
Left to rightBalancedEC 1.14.13.-, 1.14.14.1Drug metabolismHuman-GEM MAR12392
H2O[c] + 4-hydroxy-atorvastatin-lactone / para-hydroxy-atorvastatin lactone[c] = H+[c] + 4-hydroxy-atorvastatin-acid / para-hydroxy-atorvastatin acid[c]
Left to rightBalancedEC 3.1.1.2Drug metabolism
ATP[c] + H2O[c] + 4-hydroxy-atorvastatin-acid / para-hydroxy-atorvastatin acid[c] = ADP[c] + H+[c] + Pi[c] + 4-hydroxy-atorvastatin-acid / para-hydroxy-atorvastatin acid[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12394
4-hydroxy-atorvastatin-acid / para-hydroxy-atorvastatin acid[c] = 4-hydroxy-atorvastatin-acid / para-hydroxy-atorvastatin acid[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12395
HCO3-[c] + 4-hydroxy-atorvastatin-acid / para-hydroxy-atorvastatin acid[e] = HCO3-[e] + 4-hydroxy-atorvastatin-acid / para-hydroxy-atorvastatin acid[c]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12396
H+[r] + NADPH[r] + O2[r] + atorvastatin-lactone[r] = H2O[r] + NADP+[r] + 4-hydroxy-atorvastatin-lactone / para-hydroxy-atorvastatin lactone[r]
Left to rightBalancedEC 1.14.13.-, 1.14.14.1Drug metabolismHuman-GEM MAR12397
ATP[c] + 4-hydroxy-atorvastatin-acid / para-hydroxy-atorvastatin acid[c] = AMP[c] + PPi[c] + 4-hydroxy-atorvastatin-lactone / para-hydroxy-atorvastatin lactone[c]
Left to rightBalancedDrug metabolismHuman-GEM MAR12398
ATP[c] + H2O[c] + 4-hydroxy-atorvastatin-lactone / para-hydroxy-atorvastatin lactone[c] = ADP[c] + H+[c] + Pi[c] + 4-hydroxy-atorvastatin-lactone / para-hydroxy-atorvastatin lactone[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12399
4-hydroxy-atorvastatin-lactone / para-hydroxy-atorvastatin lactone[c] = 4-hydroxy-atorvastatin-lactone / para-hydroxy-atorvastatin lactone[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12400
HCO3-[c] + 4-hydroxy-atorvastatin-lactone / para-hydroxy-atorvastatin lactone[e] = HCO3-[e] + 4-hydroxy-atorvastatin-lactone / para-hydroxy-atorvastatin lactone[c]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12401
4-OH-midazolam-glucuronide[c] = 4-OH-midazolam-glucuronide[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12402
UDP-glucuronate[r] + 4-OH-midazolam[r] = H+[r] + UDP[r] + 4-OH-midazolam-glucuronide[r]
Left to rightBalancedEC 2.4.1.17Drug metabolismHuman-GEM MAR12403
H+[r] + NADPH[r] + O2[r] + Midazolam[r] = H2O[r] + NADP+[r] + 4-OH-midazolam[r]
Left to rightBalancedEC 1.14.13.-, 1.14.14.1Drug metabolismHuman-GEM MAR12404
4-OH-midazolam[c] = 4-OH-midazolam[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12405
H+[r] + NADPH[r] + O2[r] + triol metabolite of pravastatin[r] = 2 H2O[r] + NADP+[r] + 3-keto-5,6,-dihydroxy-pravastatin[r]
Left to rightBalancedEC 1.14.13.-Drug metabolismHuman-GEM MAR12406
ATP[c] + H2O[c] + 3-keto-5,6,-dihydroxy-pravastatin[c] = ADP[c] + H+[c] + Pi[c] + 3-keto-5,6,-dihydroxy-pravastatin[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12407
3-keto-5,6,-dihydroxy-pravastatin[c] = 3-keto-5,6,-dihydroxy-pravastatin[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12408
H+[r] + NADPH[r] + O2[r] + 3-alpha-iso-pravastatin[r] = H2O[r] + NADP+[r] + 5,6-epoxy-3-alpha-iso-pravastatin[r]
Left to rightBalancedEC 1.14.13.-Drug metabolismHuman-GEM MAR12409
ATP[c] + H2O[c] + 5,6-epoxy-3-alpha-iso-pravastatin[c] = ADP[c] + H+[c] + Pi[c] + 5,6-epoxy-3-alpha-iso-pravastatin[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12410
5,6-epoxy-3-alpha-iso-pravastatin[c] = 5,6-epoxy-3-alpha-iso-pravastatin[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12411
UDP-glucuronate[r] + 5-hydroxy-fluvastatin[r] = H+[r] + UDP[r] + 5-hydroxy-fluvastatin-glucuronide[r]
Left to rightBalancedDrug metabolismHuman-GEM MAR12412
5-hydroxy-fluvastatin-glucuronide[c] = 5-hydroxy-fluvastatin-glucuronide[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12413
H+[r] + NADPH[r] + O2[r] + fluvastatin[r] = H2O[r] + NADP+[r] + 5-hydroxy-fluvastatin[r]
Left to rightBalancedEC 1.14.13.-, 1.14.14.1Drug metabolismHuman-GEM MAR12414
ATP[c] + H2O[c] + 5-hydroxy-fluvastatin[c] = ADP[c] + H+[c] + Pi[c] + 5-hydroxy-fluvastatin[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12415
ATP[c] + H2O[c] + 6-alpha-OH-gliclazide[c] = ADP[c] + H+[c] + Pi[c] + 6-alpha-OH-gliclazide[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12416
H+[r] + NADPH[r] + O2[r] + Gliclazide[r] = H2O[r] + NADP+[r] + 6-alpha-OH-gliclazide[r]
Left to rightBalancedDrug metabolismHuman-GEM MAR12417
6-alpha-OH-gliclazide[c] = 6-alpha-OH-gliclazide[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12418
ATP[c] + H2O[c] + 6-beta-OH-gliclazide[c] = ADP[c] + H+[c] + Pi[c] + 6-beta-OH-gliclazide[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12419
ATP[c] + H2O[c] + 6-beta-OH-gliclazide-glucuronide[c] = ADP[c] + H+[c] + Pi[c] + 6-beta-OH-gliclazide-glucuronide[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12420
UDP-glucuronate[r] + 6-beta-OH-gliclazide[r] = H+[r] + UDP[r] + 6-beta-OH-gliclazide-glucuronide[r]
Left to rightBalancedDrug metabolismHuman-GEM MAR12421
6-beta-OH-gliclazide-glucuronide[c] = 6-beta-OH-gliclazide-glucuronide[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12422
H+[r] + NADPH[r] + O2[r] + Gliclazide[r] = H2O[r] + NADP+[r] + 6-beta-OH-gliclazide[r]
Left to rightBalancedEC 1.14.13.-, 1.14.14.1Drug metabolismHuman-GEM MAR12423
6-beta-OH-gliclazide[c] = 6-beta-OH-gliclazide[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12424
H2O[c] + 6'-beta-carboxy-simvastatin-lactone form[c] = H+[c] + 6'-beta-carboxy-simvastatin-acid form[c]
Left to rightBalancedEC 3.1.1.2Drug metabolismHuman-GEM MAR12425
ATP[c] + H2O[c] + 6'-beta-carboxy-simvastatin-acid form[c] = ADP[c] + H+[c] + Pi[c] + 6'-beta-carboxy-simvastatin-acid form[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12426
NADPH[r] + 2 O2[r] + 6'-exomethylene-simvastatin-lactone form[r] = H2O2[r] + NADP+[r] + 6'-beta-carboxy-simvastatin-lactone form[r]
Left to rightBalancedEC 1.14.13.-, 1.14.14.1Drug metabolismHuman-GEM MAR12427
ATP[c] + H2O[c] + 6-epipravastatin[c] = ADP[c] + H+[c] + Pi[c] + 6-epipravastatin[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12428
6-epipravastatin[c] = 6-epipravastatin[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12429
pravastatin[c] = 6-epipravastatin[c]
Left to rightBalancedDrug metabolismHuman-GEM MAR12430
HCO3-[c] + 6-epipravastatin[e] = HCO3-[e] + 6-epipravastatin[c]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12431
H2O[c] + 6'-beta-hydroxy-lovastatin lactone form[c] = H+[c] + 6'-beta-hydroxy-lovastatin-acid form[c]
Left to rightBalancedEC 3.1.1.2Drug metabolismHuman-GEM MAR12432
6'-beta-hydroxy-lovastatin lactone form[e] = 6'-beta-hydroxy-lovastatin lactone form[c]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12433
H2O[c] + 6'-beta-hydroxy-methyl-simvastatin-lactone form[c] = H+[c] + 6'-beta-hydroxy-methyl-simvastatin-acid form[c]
Left to rightBalancedEC 3.1.1.2Drug metabolismHuman-GEM MAR12434
ATP[c] + H2O[c] + 6'-beta-hydroxy-methyl-simvastatin-acid form[c] = ADP[c] + H+[c] + Pi[c] + 6'-beta-hydroxy-methyl-simvastatin-acid form[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12435
H+[r] + H2O[r] + NADPH[r] + O2[r] + 6'-exomethylene-simvastatin-lactone form[r] = H2O2[r] + NADP+[r] + 6'-beta-hydroxy-methyl-simvastatin-lactone form[r]
Left to rightBalancedEC 1.14.13.-, 1.14.14.1Drug metabolismHuman-GEM MAR12436
H2O[c] + 6'-beta-hydroxy simvastatin lactone[c] = H+[c] + 6'-beta-hydroxy simvastatin acid[c]
Left to rightBalancedEC 3.1.1.2Drug metabolismHuman-GEM MAR12437
ATP[c] + H2O[c] + 6'-beta-hydroxy simvastatin acid[c] = ADP[c] + H+[c] + Pi[c] + 6'-beta-hydroxy simvastatin acid[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12438
H+[r] + NADPH[r] + O2[r] + simvastatin lactone form[r] = H2O[r] + NADP+[r] + 6'-beta-hydroxy simvastatin lactone[r]
Left to rightBalancedEC 1.14.13.-, 1.14.14.1Drug metabolismHuman-GEM MAR12439