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11,951–12,000 of 12,877 reactions from Human-GEM
UDP-glucuronate[r] + 2-hydroxy-atorvastatin-acid / ortho-hydroxy-atorvastatin acid[r] = UDP[r] + 2-hydroxy-atorvastatin-acyl-glucuronide[r]
Left to rightBalancedEC 2.4.1.17Drug metabolismHuman-GEM MAR12340
ATP[c] + H2O[c] + 2-hydroxy-atorvastatin-acyl-glucuronide[c] = ADP[c] + H+[c] + Pi[c] + 2-hydroxy-atorvastatin-acyl-glucuronide[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12341
H+[r] + NADPH[r] + O2[r] + atorvastatin-acid[r] = H2O[r] + NADP+[r] + 2-hydroxy-atorvastatin-acid / ortho-hydroxy-atorvastatin acid[r]
Left to rightBalancedEC 1.14.13.-, 1.14.14.1Drug metabolismHuman-GEM MAR12342
H2O[c] + 2-hydroxy-atorvastatin-lactone / ortho-hydroxy-atorvastatin lactone[c] = H+[c] + 2-hydroxy-atorvastatin-acid / ortho-hydroxy-atorvastatin acid[c]
Left to right
ATP[c] + H2O[c] + 2-hydroxy-atorvastatin-acid / ortho-hydroxy-atorvastatin acid[c] = ADP[c] + H+[c] + Pi[c] + 2-hydroxy-atorvastatin-acid / ortho-hydroxy-atorvastatin acid[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12344
2-hydroxy-atorvastatin-acid / ortho-hydroxy-atorvastatin acid[c] = 2-hydroxy-atorvastatin-acid / ortho-hydroxy-atorvastatin acid[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12345
HCO3-[c] + 2-hydroxy-atorvastatin-acid / ortho-hydroxy-atorvastatin acid[e] = HCO3-[e] + 2-hydroxy-atorvastatin-acid / ortho-hydroxy-atorvastatin acid[c]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12346
UDP-glucuronate[r] + 2-hydroxy-atorvastatin-lactone / ortho-hydroxy-atorvastatin lactone[r] = H+[r] + UDP[r] + 2-hydroxy-atorvastatin-lactone-glucuronide[r]
Left to rightBalancedEC 2.4.1.17Drug metabolismHuman-GEM MAR12347
ATP[c] + H2O[c] + 2-hydroxy-atorvastatin-lactone-glucuronide[c] = ADP[c] + H+[c] + Pi[c] + 2-hydroxy-atorvastatin-lactone-glucuronide[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12348
H+[r] + NADPH[r] + O2[r] + atorvastatin-lactone[r] = H2O[r] + NADP+[r] + 2-hydroxy-atorvastatin-lactone / ortho-hydroxy-atorvastatin lactone[r]
Left to rightBalancedEC 1.14.13.-, 1.14.14.1Drug metabolismHuman-GEM MAR12349
ATP[c] + H2O[c] + 2-hydroxy-atorvastatin-lactone / ortho-hydroxy-atorvastatin lactone[c] = ADP[c] + H+[c] + Pi[c] + 2-hydroxy-atorvastatin-lactone / ortho-hydroxy-atorvastatin lactone[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12350
2-hydroxy-atorvastatin-lactone / ortho-hydroxy-atorvastatin lactone[c] = 2-hydroxy-atorvastatin-lactone / ortho-hydroxy-atorvastatin lactone[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12351
HCO3-[c] + 2-hydroxy-atorvastatin-lactone / ortho-hydroxy-atorvastatin lactone[e] = HCO3-[e] + 2-hydroxy-atorvastatin-lactone / ortho-hydroxy-atorvastatin lactone[c]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12352
2-hydroxy S-ibuprofen-glucuronide[c] = 2-hydroxy S-ibuprofen-glucuronide[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12353
2-hydroxy-R-ibuprofen[c] = 2-hydroxy-R-ibuprofen[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12354
UDP-glucuronate[r] + 2-hydroxy-S-ibuprofen[r] = UDP[r] + 2-hydroxy S-ibuprofen-glucuronide[r]
Left to rightBalancedEC 2.4.1.17Drug metabolismHuman-GEM MAR12355
2-hydroxy-S-ibuprofen[c] = 2-hydroxy-S-ibuprofen[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12356
H+[r] + SAH[r] + Tacrolimus[r] = SAM[r] + 31-DMT or M-II, 31-O-desmethyl tacrolimus[r]
Left to rightBalancedDrug metabolismHuman-GEM MAR12357
ATP[c] + H2O[c] + 31-DMT or M-II, 31-O-desmethyl tacrolimus[c] = ADP[c] + H+[c] + Pi[c] + 31-DMT or M-II, 31-O-desmethyl tacrolimus[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12358
31-DMT or M-II, 31-O-desmethyl tacrolimus[c] = 31-DMT or M-II, 31-O-desmethyl tacrolimus[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12359
H+[r] + 2 NADPH[r] + 2 O2[r] + pravastatin[r] = 2 H2O[r] + 2 NADP+[r] + 3'-alpha,5'beta-dihydroxy-pravastatin / 3'-alpha5'beta6'beta-trihydroxy pravastatin[r]
Left to rightBalancedEC 1.14.13.-Drug metabolismHuman-GEM MAR12360
3'-alpha,5'beta-dihydroxy-pravastatin / 3'-alpha5'beta6'beta-trihydroxy pravastatin[c] = 3'-alpha,5'beta-dihydroxy-pravastatin / 3'-alpha5'beta6'beta-trihydroxy pravastatin[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12361
HCO3-[c] + 3'-alpha,5'beta-dihydroxy-pravastatin / 3'-alpha5'beta6'beta-trihydroxy pravastatin[e] = HCO3-[e] + 3'-alpha,5'beta-dihydroxy-pravastatin / 3'-alpha5'beta6'beta-trihydroxy pravastatin[c]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12362
H+[r] + NADPH[r] + O2[r] + simvastatin lactone form[r] = NADP+[r] + 3',5'-dihydrodiol-simvastatin-lactone form[r]
Left to rightBalancedEC 1.14.13.-, 1.14.14.1Drug metabolismHuman-GEM MAR12363
ATP[c] + H2O[c] + 3',5'-dihydrodiol-simvastatin-lactone form[c] = ADP[c] + H+[c] + Pi[c] + 3',5'-dihydrodiol-simvastatin-lactone form[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12364
3-hydroxy S-ibuprofen-glucuronide[c] = 3-hydroxy S-ibuprofen-glucuronide[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12365
3-hydroxy R-ibuprofen[c] = 3-hydroxy R-ibuprofen[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12366
UDP-glucuronate[r] + 3-hydroxy S-ibuprofen[r] = UDP[r] + 3-hydroxy S-ibuprofen-glucuronide[r]
Left to rightBalancedEC 2.4.1.17Drug metabolismHuman-GEM MAR12367
3-hydroxy S-ibuprofen[c] = 3-hydroxy S-ibuprofen[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12368
H2O[c] + 3''-hydroxy-lovastatin lactone form[c] = H+[c] + 3''-hydroxy-lovastatin acid form[c]
Left to rightBalancedEC 3.1.1.2Drug metabolismHuman-GEM MAR12369
ATP[c] + H2O[c] + 3''-hydroxy-lovastatin acid form[c] = ADP[c] + H+[c] + Pi[c] + 3''-hydroxy-lovastatin acid form[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12370
2 CoA[m] + 2 FAD[m] + 2 H2O[m] + 2 NAD+[m] + 3'-S-hydroxy-pravastatin-CoA[m] = 2 acetyl-CoA[m] + 2 FADH2[m] + 2 H+[m] + 2 NADH[m] + O2[m] + 3'-S-hydroxy-pravastatin-tetranor-CoA[m]
Left to rightBalancedEC 1.3.99.-, 4.2.1.17, 1.1.1.211, 2.3.1.16Drug metabolismHuman-GEM MAR12371
2 CoA[x] + 2 H2O[x] + 2 NAD+[x] + O2[x] + 3'-S-hydroxy-pravastatin-CoA[x] = 2 acetyl-CoA[x] + 2 H+[x] + 2 H2O2[x] + 2 NADH[x] + 3'-S-hydroxy-pravastatin-tetranor-CoA[x]
Left to rightBalancedEC 1.3.3.6, 4.2.1.17, 1.1.1.35, 2.3.1.16Drug metabolismHuman-GEM MAR12372
ATP[c] + H2O[c] + 3'-S-hydroxy-pravastatin-tetranor[c] = ADP[c] + H+[c] + Pi[c] + 3'-S-hydroxy-pravastatin-tetranor[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12373
3'-S-hydroxy-pravastatin-tetranor[c] = 3'-S-hydroxy-pravastatin-tetranor[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12374
H+[r] + NADPH[r] + O2[r] + pravastatin[r] = H2O[r] + NADP+[r] + 3'-S-hydroxy-pravastatin[r]
Left to rightBalancedEC 1.14.13.-, 1.14.14.94Drug metabolismHuman-GEM MAR12375
ATP[c] + H2O[c] + 3'-S-hydroxy-pravastatin[c] = ADP[c] + H+[c] + Pi[c] + 3'-S-hydroxy-pravastatin[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12376
3'-S-hydroxy-pravastatin[c] = 3'-S-hydroxy-pravastatin[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12377
HCO3-[c] + 3'-S-hydroxy-pravastatin[e] = HCO3-[e] + 3'-S-hydroxy-pravastatin[c]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12378
H2O[c] + 3'-hydroxy-simvastatin-lactone form[c] = H+[c] + 3'-hydroxy-simvastatin-acid form[c]
Left to rightBalancedEC 3.1.1.2Drug metabolismHuman-GEM MAR12379
ATP[c] + H2O[c] + 3'-hydroxy-simvastatin-acid form[c] = ADP[c] + H+[c] + Pi[c] + 3'-hydroxy-simvastatin-acid form[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12380
6'-beta-hydroxy simvastatin lactone[r] = 3'-hydroxy-simvastatin-lactone form[r]
Left to rightBalancedEC 1.14.13.-, 1.14.14.1Drug metabolismHuman-GEM MAR12381
pravastatin[c] = 3-alpha-iso-pravastatin[c]
Left to rightBalancedDrug metabolismHuman-GEM MAR12382
ATP[c] + H2O[c] + 3-alpha-iso-pravastatin[c] = ADP[c] + H+[c] + Pi[c] + 3-alpha-iso-pravastatin[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12383
3-alpha-iso-pravastatin[c] = 3-alpha-iso-pravastatin[e]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12384
HCO3-[c] + 3-alpha-iso-pravastatin[e] = HCO3-[e] + 3-alpha-iso-pravastatin[c]
ReversibleBalancedTransportDrug metabolismHuman-GEM MAR12385
SAM[c] + 3-hydroxy-acetaminophen[c] = H+[c] + SAH[c] + 3-methoxy-acetaminophen[c]
Left to rightBalancedDrug metabolismHuman-GEM MAR12386
H+[r] + NADPH[r] + O2[r] + acetaminophen/paracetamol[r] = H2O[r] + NADP+[r] + 3-hydroxy-acetaminophen[r]
Left to rightBalancedEC 1.14.13.-Drug metabolismHuman-GEM MAR12387
ATP[c] + H2O[c] + 3-hydroxy-acetaminophen[c] = ADP[c] + H+[c] + Pi[c] + 3-hydroxy-acetaminophen[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12388
ATP[c] + H2O[c] + 4-beta-OH-gliclazide[c] = ADP[c] + H+[c] + Pi[c] + 4-beta-OH-gliclazide[e]
Left to rightBalancedTransportDrug metabolismHuman-GEM MAR12389