Skip to content

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

11,501–11,550 of 18,558 reactions from Rhea

N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein] + H2O = L-asparaginyl-[protein] + ADP-D-ribose
Direction not assertedBalance undeterminableRhea 58252
O-(ADP-D-ribosyl)-L-seryl-[protein] + H2O = ADP-D-ribose + L-seryl-[protein]
Left to rightBalance undeterminableRhea 58256
O-(ADP-D-ribosyl)-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + ADP-D-ribose
Direction not assertedBalance undeterminableRhea 58260
a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
ReversibleBalance undeterminableRhea 58264
[protein]-C-terminal glycine + NAD(+) = [protein]-C-terminal O-(ADP-D-ribosyl)-glycine + nicotinamide
Left to rightBalance undeterminableRhea 58268
6 ATP = cyclic hexaadenylate + 6 diphosphate
Direction not assertedBalancedRhea 58276

4 ATP = cyclic tetraadenylate + 4 diphosphate

Direction not assertedBalancedRhea 58280

5,6-dihydrothymine + NADP(+) = thymine + NADPH + H(+)

Right to leftBalancedRhea 58284

beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + 25-substituted-cholesterol = 25-substituted-cholesteryl beta-D-glucoside + N-hexadecanoylsphing-4-enine

Direction not assertedBalance undeterminableRhea 58296

25-substituted-cholesteryl beta-D-glucoside + H2O = 25-substituted-cholesterol + D-glucose

Direction not assertedBalance undeterminableRhea 58312

beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine

ReversibleBalancedRhea 58316

beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4E-enine + cholesterol = N-(9Z-octadecenoyl)-sphing-4-enine + cholesteryl 3-beta-D-glucoside

ReversibleBalancedRhea 58324

(Z)-non-6-en-1-ol + NADP(+) = (Z)-non-6-enal + NADPH + H(+)

Direction not assertedBalancedRhea 58328

(E)-non-2-en-1-ol + NADP(+) = (E)-non-2-enal + NADPH + H(+)

Direction not assertedBalancedRhea 58332

a 4-hydroxynonen-1-ol + NADP(+) = a 4-hydroxynonenal + NADPH + H(+)

Direction not assertedBalancedRhea 58336

beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O = chenodeoxycholate + D-glucose

Left to rightBalancedRhea 58340

beta-D-glucosyl-(1->3)-O-lithocholate + H2O = lithocholate + D-glucose

Left to rightBalancedRhea 58344

N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 2-oxoglutarate + 2 O2 = L-arginyl-[protein] + 2 formaldehyde + 2 succinate + 2 CO2

Direction not assertedBalance undeterminableRhea 58348

N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2-oxoglutarate + O2 = N(omega)-methyl-L-arginyl-[protein] + formaldehyde + succinate + CO2

Direction not assertedBalance undeterminableRhea 58352

N(omega)-methyl-L-arginyl-[protein] + 2-oxoglutarate + O2 = L-arginyl-[protein] + formaldehyde + succinate + CO2

Direction not assertedBalance undeterminableRhea 58356

L-lysyl-[protein] + 2-oxoglutarate + O2 = (5S)-5-hydroxy-L-lysyl-[protein] + succinate + CO2

Direction not assertedBalance undeterminableRhea 58360

a medium-chain primary fatty alcohol + NADP(+) = a medium-chain fatty aldehyde + NADPH + H(+)

Direction not assertedBalance undeterminableRhea 58364

(2E,6Z)-nona-2,6-dien-1-ol + NADP(+) = (2E,6Z)-nona-2,6-dienal + NADPH + H(+)

Direction not assertedBalancedRhea 58368

(E)-oct-2-en-1-ol + NADP(+) = (2E)-octenal + NADPH + H(+)

Direction not assertedBalancedRhea 58372

decan-1-ol + NADP(+) = decanal + NADPH + H(+)

Direction not assertedBalancedRhea 58376

nonan-1-ol + NADP(+) = nonanal + NADPH + H(+)

Direction not assertedBalancedRhea 58380

octan-1-ol + NADP(+) = octanal + NADPH + H(+)

Direction not assertedBalancedRhea 58384

all-trans-hexaprenyl diphosphate + 4-aminobenzoate = 4-amino-3-(all-trans-hexaprenyl)benzoate + diphosphate

Direction not assertedBalancedRhea 58388

4-amino-3-(all-trans-hexaprenyl)benzoate + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = 4-amino-5-hydroxy-3-(all-trans-hexaprenyl)benzoate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O

Direction not assertedBalance undeterminableRhea 58392

4-amino-5-hydroxy-3-(all-trans-hexaprenyl)benzoate + 4 reduced [2Fe-2S]-[ferredoxin] + O2 + 5 H(+) = 3,4-dihydroxy-5-(all-trans-hexaprenyl)benzoate + 4 oxidized [2Fe-2S]-[ferredoxin] + NH4(+) + H2O

Direction not assertedBalance undeterminableRhea 58396

heptan-1-ol + NADP(+) = heptanal + NADPH + H(+)

Direction not assertedBalancedRhea 58400

hexan-1-ol + NADP(+) = hexanal + NADPH + H(+)

Direction not assertedBalancedRhea 58404

undecan-1-ol + NADP(+) = undecanal + NADPH + H(+)

Direction not assertedBalancedRhea 58408

L-aspartate 4-semialdehyde + reduced 2[4Fe-4S]-[ferredoxin] + hydrogen sulfide + 3 H(+) = oxidized 2[4Fe-4S]-[ferredoxin] + L-homocysteine + H2O

Direction not assertedBalance undeterminableRhea 58412

(E)-4-hydroxynon-2-en-1-ol + NADP(+) = (E)-4-hydroxynon-2-enal + NADPH + H(+)

Direction not assertedBalancedRhea 58416

prenol + NADP(+) = 3-methyl-2-butenal + NADPH + H(+)

Direction not assertedBalancedRhea 58420

(E)-hex-2-en-1-ol + NADP(+) = (E)-hex-2-enal + NADPH + H(+)

Direction not assertedBalancedRhea 58424

(E,E)-2,4-hexadien-1-ol + NADP(+) = (E,E)-2,4-hexadienal + NADPH + H(+)

Direction not assertedBalancedRhea 58428

(E)-4-oxonon-2-en-1-ol + NADP(+) = (E)-4-oxonon-2-enal + NADPH + H(+)

Right to leftBalancedRhea 58432

4-methylpentan-1-ol + NADP(+) = 4-methylpentanal + NADPH + H(+)

Direction not assertedBalancedRhea 58436

N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)

Left to rightBalance undeterminableRhea 58440

N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine = N-terminal N-methyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalance undeterminableRhea 58444

N-terminal N-methyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine = N-terminal N,N-dimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalance undeterminableRhea 58448

N-terminal N,N-dimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalance undeterminableRhea 58452

(2R)-2-O-(alpha-D-mannosyl)-glycerate + H2O = (R)-glycerate + D-mannose

Direction not assertedBalancedRhea 58456

sn-glycerol 3-phosphocholine + an acyl-CoA = a monoacyl-sn-glycero-3-phosphocholine + CoA

Direction not assertedBalance undeterminableRhea 58460

a neolactoside nLc4Cer + UDP-N-acetyl-alpha-D-glucosamine = a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + UDP + H(+)

Direction not assertedBalance undeterminableRhea 58464

N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 2-oxoglutarate + 2 O2 = L-arginyl-[protein] + 2 formaldehyde + 2 succinate + 2 CO2

Direction not assertedBalance undeterminableRhea 58468

N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2-oxoglutarate + O2 = N(omega)-methyl-L-arginyl-[protein] + formaldehyde + succinate + CO2

Direction not assertedBalance undeterminableRhea 58472

sn-glycerol 3-phosphocholine + an acyl-CoA = a 1-acyl-sn-glycero-3-phosphocholine + CoA

Direction not assertedBalance undeterminableRhea 58476

Page 231 of 372