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ReactionsRhea and Human-GEM, by subsystem
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Reference

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

9,251–9,300 of 18,558 reactions from Rhea

dibenzothiophene 5-oxide + FMNH2 + O2 = dibenzothiophene 5,5-dioxide + FMN + H2O + H(+)
Direction not assertedBalancedRhea 49080
(-)-matairesinol + reduced [NADPH--hemoprotein reductase] + O2 = (-)-pluviatolide + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)
Direction not assertedBalance undeterminableRhea 49084
squalene + FAD + H2O + H(+) = hydroxysqualene + FADH2
Direction not assertedBalancedRhea 49088
1-hexadecanoyl-sn-glycero-3-phosphate + H2O = sn-glycerol 3-phosphate + hexadecanoate + H(+)
Left to rightBalancedRhea 49092
Mg-protoporphyrin IX 13-monomethyl ester + 3 S-adenosyl-L-methionine + H2O = 3,8-divinyl protochlorophyllide a + 3 5'-deoxyadenosine + 3 L-methionine + 4 H(+)
Direction not assertedBalancedRhea 49096
Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-methionine + H2O = Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + 5'-deoxyadenosine + L-methionine + H(+)
Direction not asserted

Balanced

Rhea 49100

Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine = Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + 5'-deoxyadenosine + L-methionine + H(+)

Direction not assertedBalancedRhea 49104

Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine = 3,8-divinyl protochlorophyllide a + 5'-deoxyadenosine + L-methionine + 2 H(+)

Direction not assertedBalancedRhea 49108

phenazine-1-carboxylate + S-adenosyl-L-methionine = 5-methyl-phenazine-1-carboxylate + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 49112

protodeoxyviolaceinate + NADPH + O2 + H(+) = deoxyviolaceinate + NADP(+) + H2O

Direction not assertedBalancedRhea 49116

protoviolaceinate + NADPH + O2 + H(+) = violaceinate + NADP(+) + H2O

Direction not assertedBalancedRhea 49120

protodeoxyviolaceinate + NADPH + O2 + H(+) = protoviolaceinate + NADP(+) + H2O

Direction not assertedBalancedRhea 49124

N-acetyl-demethyl-L-phosphinothricin + AH2 + 2 S-adenosyl-L-methionine = N-acetyl-L-phosphinothricin + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)

Direction not assertedBalancedRhea 49128

an adenosine in tRNA + S-adenosyl-L-methionine = an N(1)-methyladenosine in tRNA + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalance undeterminableRhea 49132

L-methionyl-[protein] + NADPH + O2 + H(+) = L-methionyl-S-oxide-[protein] + NADP(+) + H2O

Direction not assertedBalance undeterminableRhea 49136

dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + 2 reduced [2Fe-2S]-[ferredoxin] + 2 H(+) = dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O

Direction not assertedBalance undeterminableRhea 49140

dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + 2-oxoglutarate = dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + L-glutamate

Direction not assertedBalancedRhea 49144

dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + 2 S-adenosyl-L-methionine = dTDP-alpha-D-forosamine + 2 S-adenosyl-L-homocysteine + 2 H(+)

Direction not assertedBalancedRhea 49148

dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + S-adenosyl-L-methionine = dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 49152

dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + S-adenosyl-L-methionine = dTDP-alpha-D-forosamine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 49156

1,4-cineole + reduced [NADPH--hemoprotein reductase] + O2 = 2-exo-hydroxy-1,4-cineole + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 49160

a bacteriochlorophyllide c + S-adenosyl-L-methionine + H2O = a 7(1)-hydroxybacteriochlorophyllide c + 5'-deoxyadenosine + L-methionine + H(+)

Direction not assertedBalance undeterminableRhea 49164

8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine = 8,12-diethyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 49168

8,12-diethyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine = 12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 49172

12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine = 12-ethyl-8-isobutyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 49176

a bacteriochlorophyllide d + S-adenosyl-L-methionine = a bacteriochlorophyllide c + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalance undeterminableRhea 49180

chlorophyllide a + H2O + H(+) = 8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + methanol + CO2

Direction not assertedBalancedRhea 49184

a bacteriochlorophyllide d = a 3-vinylbacteriochlorophyllide d + H2O

Direction not assertedBalance undeterminableRhea 49188

calcitriol + 2 reduced [adrenodoxin] + O2 + 2 H(+) = 1alpha,23S,25-trihydroxycholecalciferol + 2 oxidized [adrenodoxin] + H2O

Left to rightBalance undeterminableRhea 49192

secalciferol + 2 reduced [adrenodoxin] + O2 + 2 H(+) = 25-hydroxy-24-oxocalciol + 2 oxidized [adrenodoxin] + 2 H2O

Left to rightBalance undeterminableRhea 49196

aldehydo-D-mannose 6-phosphate + phosphoenolpyruvate + H2O = 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + phosphate

Left to rightBalancedRhea 49200

20S-hydroxycholecalciferol + 2 reduced [adrenodoxin] + O2 + 2 H(+) = 20S,24R-dihydroxycholecalciferol + 2 oxidized [adrenodoxin] + H2O

Left to rightBalance undeterminableRhea 49204

20S-hydroxycholecalciferol + 2 reduced [adrenodoxin] + O2 + 2 H(+) = 20S,24S-dihydroxycholecalciferol + 2 oxidized [adrenodoxin] + H2O

Direction not assertedBalance undeterminableRhea 49208

20S-hydroxycholecalciferol + 2 reduced [adrenodoxin] + O2 + 2 H(+) = 20S,25-dihydroxycholecalciferol + 2 oxidized [adrenodoxin] + H2O

Left to rightBalance undeterminableRhea 49212

3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + H2O = 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + phosphate

Direction not assertedBalancedRhea 49216

3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + CTP = CMP-beta-3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + diphosphate

Direction not assertedBalancedRhea 49220

dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + reduced [flavodoxin] = dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + oxidized [flavodoxin] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 49224

bacteriochlorophyllide a + (2E,6E,10E)-geranylgeranyl diphosphate + H(+) = geranylgeranyl-bacteriochlorophyllide a + diphosphate

Direction not assertedBalancedRhea 49228

D-mannose(out) + N(pros)-phospho-L-histidyl-[protein] = D-mannose 6-phosphate(in) + L-histidyl-[protein]

Direction not assertedBalance undeterminableRhea 49232

N(pros)-phospho-L-histidyl-[protein](out) + sucrose = sucrose 6(G)-phosphate(in) + L-histidyl-[protein]

Direction not assertedBalance undeterminableRhea 49236

N(pros)-phospho-L-histidyl-[protein] + N-acetyl-D-glucosamine(out) = N-acetyl-D-glucosamine 6-phosphate(in) + L-histidyl-[protein]

Direction not assertedBalance undeterminableRhea 49240

resolvin E1 + NAD(+) = 18-oxo-resolvin E1 + NADH + H(+)

Left to rightBalancedRhea 49244

galactitol(out) + N(pros)-phospho-L-histidyl-[protein] = galactitol 1-phosphate(in) + L-histidyl-[protein]

Direction not assertedBalance undeterminableRhea 49248

D-fructose(out) + N(pros)-phospho-L-histidyl-[protein] = D-fructose 1-phosphate(in) + L-histidyl-[protein]

Direction not assertedBalance undeterminableRhea 49252

2-amino-2-deoxy-D-gluconate(out) + N(pros)-phospho-L-histidyl-[protein] = 2-amino-2-deoxy-D-gluconate 6-phosphate(in) + L-histidyl-[protein]

Direction not assertedBalance undeterminableRhea 49256

N(pros)-phospho-L-histidyl-[protein] + D-galactose(out) = D-galactose 6-phosphate(in) + L-histidyl-[protein]

Direction not assertedBalance undeterminableRhea 49260

5-O-[(E)-caffeoyl]-shikimate + H2O = shikimate + (E)-caffeate + H(+)

Direction not assertedBalancedRhea 49264

25-hydroxy-24-oxocalciol + 2 reduced [adrenodoxin] + O2 + 2 H(+) = 23S,25-dihydroxy-24-oxocholecalciferol + 2 oxidized [adrenodoxin] + H2O

Left to rightBalance undeterminableRhea 49268

alfacalcidol + reduced [NADPH--hemoprotein reductase] + O2 = calcitriol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 49272

phytyl phosphate + CTP = phytyl diphosphate + CDP

Direction not assertedBalancedRhea 49276

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