Skip to content

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

751–800 of 18,558 reactions from Rhea

cis-4-coumarate + UDP-alpha-D-glucose = 4'-O-beta-D-glucosyl-cis-4-coumarate + UDP + H(+)
Direction not assertedBalancedRhea 13129
a di-trans,poly-cis-dolichol + CTP = a di-trans,poly-cis-dolichyl phosphate + CDP + H(+)
Left to rightBalance undeterminableRhea 13133
cycloartenol + S-adenosyl-L-methionine = cyclolaudenol + S-adenosyl-L-homocysteine + H(+)
Direction not assertedBalancedRhea 13137
2-methylpropanoyl-CoA = butanoyl-CoA
Direction not assertedBalancedRhea 13141
4-O-beta-D-mannopyranosyl-N-acetyl-D-glucosamine + phosphate = alpha-D-mannose 1-phosphate + N-acetyl-D-glucosamine
Direction not assertedBalancedRhea 13145
A + NADPH + H(+) = AH2 + NADP(+)
Direction not assertedBalancedRhea 13149
(R)-glycerate + CO2 + NAD(+) = 2-hydroxy-3-oxosuccinate + NADH + 2 H(+)

Direction not assertedBalancedRhea 13153

(R)-glycerate + CO2 + NADP(+) = 2-hydroxy-3-oxosuccinate + NADPH + 2 H(+)

Direction not assertedBalancedRhea 13157

L-threonine + NAD(+) = (2S)-2-amino-3-oxobutanoate + NADH + H(+)

Direction not assertedBalancedRhea 13161

maleate = fumarate

Direction not assertedBalancedRhea 13169

phosphite + NAD(+) + H2O = phosphate + NADH + 3 H(+)

Direction not assertedBalancedRhea 13173

6-phospho-5-dehydro-2-deoxy-D-gluconate = 3-oxopropanoate + dihydroxyacetone phosphate

Direction not assertedBalancedRhea 13177

nitrate(out) + ATP + H2O = nitrate(in) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 13181

4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH4(+)

Left to rightBalancedRhea 13185

a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 a fatty acid + 2 H(+)

Left to rightBalance undeterminableRhea 13189

5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate

Direction not assertedBalancedRhea 13193

sulfite + UDP-alpha-D-glucose + H(+) = UDP-alpha-D-6-sulfoquinovose + H2O

Direction not assertedBalancedRhea 13197

L-arginine + glycine = guanidinoacetate + L-ornithine

Left to rightBalancedRhea 13201

a monosaccharide 1-phosphate + UTP + H(+) = a UDP-monosaccharide + diphosphate

Direction not assertedBalance undeterminableRhea 13205

succinate semialdehyde + NADP(+) + H2O = succinate + NADPH + 2 H(+)

Direction not assertedBalancedRhea 13213

succinate semialdehyde + NAD(+) + H2O = succinate + NADH + 2 H(+)

Left to rightBalancedRhea 13217

(R)-mevalonate + NAD(+) = (R)-mevaldate + NADH + H(+)

Direction not assertedBalancedRhea 13221

guanosine + phosphate = alpha-D-ribose 1-phosphate + guanine

Left to rightBalancedRhea 13233

D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate

Left to rightBalancedRhea 13237

beta-L-fucose + ATP = beta-L-fucose 1-phosphate + ADP + H(+)

Direction not assertedBalancedRhea 13241

D-threo-isocitrate = glyoxylate + succinate

Direction not assertedBalancedRhea 13245

(R)-2-hydroxypropyl-coenzyme M + NAD(+) = 2-oxopropyl-coenzyme M + NADH + H(+)

Direction not assertedBalancedRhea 13249

1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+)

ReversibleBalancedRhea 13253

1-amino-1-deoxy-scyllo-inositol 4-phosphate + L-arginine = 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + L-ornithine

Direction not assertedBalancedRhea 13265

a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose

Left to rightBalance undeterminableRhea 13269

an alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol + 3'-phosphoadenylyl sulfate = a 6-sulfo-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol + adenosine 3',5'-bisphosphate + H(+)

Direction not assertedBalance undeterminableRhea 13273

[L-4-(L-arginin-2-N-yl)aspartate](n) + L-aspartate + ATP = [L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ADP + phosphate + H(+)

Direction not assertedBalance undeterminableRhea 13277

(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+) = 2-methyl-3-oxobutanoyl-CoA + NADH + H(+)

Left to rightBalancedRhea 13281

L-cysteine + L-glutamate + ATP = gamma-L-glutamyl-L-cysteine + ADP + phosphate + H(+)

Left to rightBalancedRhea 13285

a di-trans,poly-cis-dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UMP

Left to rightBalance undeterminableRhea 13289

a sterol + a 1,2-diacyl-sn-glycerol = a sterol ester + a 1-acyl-sn-glycerol

Direction not assertedBalance undeterminableRhea 13301

(E)-sinapate + UDP-alpha-D-glucose = 1-O-(trans-sinapoyl)-beta-D-glucose + UDP

Direction not assertedBalancedRhea 13305

vanillin + NAD(+) + H2O = vanillate + NADH + 2 H(+)

Direction not assertedBalancedRhea 13309

sarcosine + O2 + H2O = formaldehyde + glycine + H2O2

Direction not assertedBalancedRhea 13313

(2R,3R)-tartrate + H(+) = (R)-glycerate + CO2

Direction not assertedBalancedRhea 13317

(R)-3,3-dimethylmalate + NAD(+) = 3-methyl-2-oxobutanoate + CO2 + NADH

Direction not assertedBalancedRhea 13321

UDP-N-acetyl-alpha-D-glucosamine + 2 NAD(+) + H2O = UDP-2-acetamido-2-deoxy-alpha-D-glucuronate + 2 NADH + 3 H(+)

Direction not assertedBalancedRhea 13325

a 3-oxosteroid + A = a 3-oxo-Delta(1)-steroid + AH2

Direction not assertedBalance undeterminableRhea 13329

beta-D-fructose 2,6-bisphosphate + H2O = beta-D-fructose 2-phosphate + phosphate

Direction not assertedBalancedRhea 13333

D-glucurono-6,2-lactone + H2O = D-glucuronate + H(+)

Direction not assertedBalancedRhea 13337

reduced [flavodoxin] + a menaquinone + 2 S-adenosyl-L-methionine = an 8-methylmenaquinone + oxidized [flavodoxin] + 5'-deoxyadenosine + L-methionine + S-adenosyl-L-homocysteine + 3 H(+)

Direction not assertedBalance undeterminableRhea 13341

L-cysteinyl-[protein] + (2E,6E)-farnesyl diphosphate = S-(2E,6E)-farnesyl-L-cysteinyl-[protein] + diphosphate

Direction not assertedBalance undeterminableRhea 13345

jasmonate + S-adenosyl-L-methionine = methyl (-)-jasmonate + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 13349

4-O-[di(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-L-ribitol = 4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CMP + n H(+)

Direction not assertedBalance undeterminableRhea 13353

3-hydroxypropanoate + NAD(+) = 3-oxopropanoate + NADH + H(+)

Direction not assertedBalancedRhea 13357

Page 16 of 372