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Proteins/UNIPROT:Q8NBI6

XXYLT1

Protein·UNIPROT:Q8NBI6

Open in the graph

Alpha-1,3-xylosyltransferase, which elongates the O-linked xylose-glucose disaccharide attached to EGF-like repeats in the extracellular domain of target proteins by catalyzing the addition of the second xylose. Known targets include Notch proteins and coagulation factors, such as F9..

Function from UniProtKB (Q8NBI6), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

7 statements

7 statements · 3 reference databases · Subject: XXYLT1 · Sources: Hetionet, Rhea, UniProt

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SLC22A31 covaries with XXYLT1ProteinHetionet hetionet:covaries:146429-152002Inferred only
XXYLT1 covaries with ZFP36ProteinHetionet hetionet:covaries:152002-7538Inferred only
CUL4A interacts with XXYLT1ProteinHetionet hetionet:interacts:152002-8451Inferred only
UBC interacts with XXYLT1ProteinHetionet hetionet:interacts:152002-7316Inferred only
XXYLT1 requires the cofactor magnesium(2+)CompoundUniProt Q8NBI6Inferred only
XXYLT1 requires the cofactor Mn(2+)CompoundUniProt Q8NBI6Inferred only
UDP-alpha-D-xylose is a substrate of XXYLT1CompoundRhea RHEA:22820Inferred only

Reactions

1 reaction

3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein]+UDP-alpha-D-xylose3-O-[alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein]+UDP+hydron
Catalysed by XXYLT1
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:22820CC BY 4.0Reference data

Other names

2 names

Resolves to: XXYLT1

Also called: C3orf21UDP-xylose:alpha-xyloside alpha-1,3-xylosyltransferase

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