Proteins/UNIPROT:Q969E3

UCN3

ProteinUNIPROT:Q969E3

Hormone that plays a central role in whole body adaptation to stress. Released by the hypothalamus primarily in response to physical or psychological stress and acts by binding to CRH receptor CRHR2. UCN3-dependent signaling plays a key role in the metabolic regulation and energy homeostasis in responses to stress, acting as an anxiolytic. Promotes energy balance by reducing food intake, improving insulin sensitivity and managing blood glucose levels in response to metabolic stress (By similarity). In contrast to CRH and UCN, does not activate the hypothalamus-pituitary-adrenal axis to promote corticotropin hormone (ACTH) production..

Function from UniProtKB (Q969E3), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

9 statements

9 statements · 3 reference databases · Subject: UCN3 · Sources: gene ontology, Hetionet, Reactome

Order

CRHR1 interacts with UCN3ProteinHetionet hetionet:interacts:114131-1394Inferred only
CRHR2 interacts with UCN3ProteinHetionet hetionet:interacts:114131-1395Inferred only
IL10RB interacts with UCN3ProteinHetionet hetionet:interacts:114131-3588Inferred only
UCN3 participates in Class B/2 (Secretin family receptors)PathwayReactome R-HSA-373080Inferred only
UCN3 participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
UCN3 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
UCN3 participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
UCN3 regulates positive regulation of insulin secretionBiological processgene ontology Q969E3|GO:0032024Inferred only
UCN3 regulates positive regulation of membrane potentialBiological processgene ontology Q969E3|GO:0045838Inferred only

Other names

4 names

Resolves to: UCN3

Also called: SPCStresscopinUcn IIIUrocortin III

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