Proteins/UNIPROT:Q7Z2W7

TRPM8

ProteinUNIPROT:Q7Z2W7Transient receptor potential cation channel subfamily M member 8

Non-selective ion channel permeable to monovalent and divalent cations, including Na(+), K(+), and Ca(2+), with higher permeability for Ca(2+). Activated by multiple factors, such as temperature, voltage, pressure, and changes in osmolality. Activated by cool temperatures (<23-28 degrees Celsius) and by chemical ligands evoking a sensation of coolness, such as menthol and icilin therefore plays a central role in the detection of environmental cold temperatures. TRPM8 is a voltage-dependent channel; its activation by cold or chemical ligands shifts its voltage thresholds towards physiological membrane potentials, leading to the opening of the channel. In addition to its critical role in temperature sensing, regulates basal tear secretion by sensing evaporation-induced cooling and changes in osmolality (By similarity). May play a role in prostate cancer cell migration..

[Isoform 2]: Negatively regulates menthol- and cold-induced channel activity by stabilizing the closed state of the channel..

[Isoform 3]: Negatively regulates menthol- and cold-induced channel activity by stabilizing the closed state of the channel..

Function from UniProtKB (Q7Z2W7), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

9 statements

9 statements · 4 reference databases · Subject: TRPM8 · Sources: gene ontology, Reactome, Rhea, WikiPathways

Order

TRPM8 participates in 2q37 copy number variation syndromePathwayWikiPathways WP5224Inferred only
TRPM8 participates in Ion channel transportPathwayReactome R-HSA-983712Inferred only
TRPM8 participates in Stimuli-sensing channelsPathwayReactome R-HSA-2672351Inferred only
TRPM8 participates in Transport of small moleculesPathwayReactome R-HSA-382551Inferred only
TRPM8 participates in TRP channelsPathwayReactome R-HSA-3295583Inferred only
TRPM8 regulates positive regulation of cold-induced thermogenesisBiological processgene ontology Q7Z2W7|GO:0120162Inferred only
Ca(2+) is transported by TRPM8CompoundRhea RHEA:29671Inferred only
K(+) is transported by TRPM8CompoundRhea RHEA:29463Inferred only
sodium(1+) is transported by TRPM8CompoundRhea RHEA:34963Inferred only

Reactions

3 reactions

K(+)K(+)
Transported by ANO9 or HTR3E or KCNU1 or KCNJ18 or TMEM150C or KCNK1 or KCNK3 or GRIN2D or KCNN4 or KCNQ3 or KCNQ2 or HCN1 and 136 more alternatives
Reaction pageDirection not assertedBalanced
Rhea RHEA:29463CC BY 4.0Reference data

Other names

6 names

Resolves to: TRPM8

Also called: Long transient receptor potential channel 6LTrpC-6LTRPC6Transient receptor potential p8Trp-p8TRPP8

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