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Proteins/UNIPROT:Q9Y210

TRPC6

Protein·UNIPROT:Q9Y210

Open in the graph

Non-selective, calcium-permeable cation channel. Mediates calcium entry following G(q)-coupled receptor or receptor tyrosine kinase activation, which triggers phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositides and production of diacylglycerol (DAG) that directly activates TRPC6. Does not appear to be activated by depletion of intracellular calcium stores. Mediates depolarization of intrinsically photosensitive retinal ganglion cells (ipRGCs) in response to light-induced melanopsin (OPN4)-mediated phototransduction via G(q)-PLC signaling, likely by forming heteromeric TRPC6-TRPC7 channels (By similarity)..

Function from UniProtKB (Q9Y210), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

2 rows

familial idiopathic steroid-resistant nephrotic syndrome has a germline basis in TRPC6DiseaseGenCC HGNC:12338|MONDO:0019006Inferred only
focal segmental glomerulosclerosis 2 has a germline basis in TRPC6DiseaseGenCC HGNC:12338|MONDO:0011390Inferred only

Statements

36 statements

36 statements · 5 reference databases · Subject: TRPC6 · Sources: gene ontology, Hetionet, Reactome, Rhea, WikiPathways

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FYN interacts with TRPC6ProteinHetionet hetionet:interacts:2534-7225Inferred only
ITPR3 interacts with TRPC6ProteinHetionet hetionet:interacts:3710-7225Inferred only
MX1 interacts with TRPC6ProteinHetionet hetionet:interacts:4599-7225Inferred only
TRPC6 interacts with ORAI1ProteinHetionet hetionet:interacts:7225-84876Inferred only
TRPC6 interacts with RNF24ProteinHetionet hetionet:interacts:11237-7225Inferred only
SRC interacts with TRPC6ProteinHetionet hetionet:interacts:6714-7225Inferred only
TRPC3 interacts with TRPC6ProteinHetionet hetionet:interacts:7222-7225Inferred only
TRPC6 interacts with TRPC7ProteinHetionet hetionet:interacts:57113-7225Inferred only
TRPC6 interacts with TRPM2ProteinHetionet hetionet:interacts:7225-7226Inferred only
TRPC6 participates in Affected pathways in Duchenne muscular dystrophyPathwayWikiPathways WP5356Inferred only
TRPC6 participates in Axon guidancePathwayReactome R-HSA-422475Inferred only
TRPC6 participates in BDNF TrkB signalingPathwayWikiPathways WP3676Inferred only

Show the remaining 24

TRPC6 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
TRPC6 participates in Effects of PIP2 hydrolysisPathwayReactome R-HSA-114508Inferred only
TRPC6 participates in Elevation of cytosolic Ca2+ levelsPathwayReactome R-HSA-139853Inferred only
TRPC6 participates in G alpha (q) signalling eventsPathwayReactome R-HSA-416476Inferred only
TRPC6 participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
TRPC6 participates in HemostasisPathwayReactome R-HSA-109582Inferred only
TRPC6 participates in Ion channel transportPathwayReactome R-HSA-983712Inferred only
TRPC6 participates in Nephrotic syndromePathwayWikiPathways WP4758Inferred only
TRPC6 participates in Nervous system developmentPathwayReactome R-HSA-9675108Inferred only
TRPC6 participates in Netrin-1 signalingPathwayReactome R-HSA-373752Inferred only
TRPC6 participates in Platelet activation, signaling and aggregationPathwayReactome R-HSA-76002Inferred only
TRPC6 participates in Platelet calcium homeostasisPathwayReactome R-HSA-418360Inferred only
TRPC6 participates in Platelet homeostasisPathwayReactome R-HSA-418346Inferred only
TRPC6 participates in Primary focal segmental glomerulosclerosis FSGS PathwayWikiPathways WP2572Inferred only
TRPC6 participates in Role of second messengers in netrin-1 signalingPathwayReactome R-HSA-418890Inferred only
TRPC6 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
TRPC6 participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
TRPC6 participates in Stimuli-sensing channelsPathwayReactome R-HSA-2672351Inferred only
TRPC6 participates in Transport of small moleculesPathwayReactome R-HSA-382551Inferred only
TRPC6 participates in TRP channelsPathwayReactome R-HSA-3295583Inferred only
TRPC6 regulates positive regulation of calcium ion transportBiological processgene ontology Q9Y210|GO:0051928Inferred only
TRPC6 regulates positive regulation of ion transmembrane transporter activityBiological processgene ontology Q9Y210|GO:0032414Inferred only
TRPC6 regulates regulation of cytosolic calcium ion concentrationBiological processgene ontology Q9Y210|GO:0051480Inferred only
Ca(2+) is transported by TRPC6CompoundRhea RHEA:29671Inferred only

Reactions

1 reaction

Ca(2+)Ca(2+)
Transported by ANO9 or HTR3E or TMEM150C or CACNA1A or GRIN2D or P2RX6 or GRID2 or CACNA1G or GRIN3B or CACNA1F or TRPA1 or TRPM2 and 106 more alternatives
Reaction pageRight to leftBalanced
Rhea RHEA:29671CC BY 4.0Reference data

Other names

3 names

Resolves to: TRPC6

Also called: Transient receptor protein 6TRP-6TRP6

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