TNFSF14

Cytokine that binds to TNFRSF3/LTB and TNFRSF14/HVEM and plays major roles in immune system regulation. Upon binding to TNFRSF14/HVEM, delivers costimulatory signals to T cells, leading to T cell proliferation and IFNG production. Binds to the decoy receptor TNFRSF6B thereby disrupts the activation signal initiated by TNFSF14, resulting in reduced T-cell activation..

Function from UniProtKB (O43557), read 2026-09-23. CC BY 4.0.