Proteins/UNIPROT:O95379

TNFAIP8

ProteinUNIPROT:O95379

Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation..

Function from UniProtKB (O95379), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

13 statements

13 statements · 3 reference databases · Subject: TNFAIP8 · Sources: gene ontology, Hetionet, Reactome

Order

TNFAIP8 interacts with MED4ProteinHetionet hetionet:interacts:25816-29079Inferred only
TNFAIP8 interacts with PLEKHF2ProteinHetionet hetionet:interacts:25816-79666Inferred only
PTP4A1 interacts with TNFAIP8ProteinHetionet hetionet:interacts:25816-7803Inferred only
TNFAIP8 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
TNFAIP8 participates in Metabolism of lipidsPathwayReactome R-HSA-556833Inferred only
TNFAIP8 participates in Phospholipid metabolismPathwayReactome R-HSA-1483257Inferred only
TNFAIP8 participates in PI MetabolismPathwayReactome R-HSA-1483255Inferred only
TNFAIP8 regulates negative regulation of apoptotic processBiological processgene ontology O95379|GO:0043066Inferred only
TNFAIP8 regulates positive regulation of apoptotic processBiological processgene ontology O95379|GO:0043065Inferred only
TNFAIP8 regulates regulation of intracellular signal transductionBiological processgene ontology O95379|GO:1902531Inferred only
FAH increases the expression of TNFAIP8ProteinHetionet hetionet:regulates:2184-25816Inferred only
GAPDH decreases the expression of TNFAIP8ProteinHetionet hetionet:regulates:2597-25816Inferred only

Show the remaining 1

SRF increases the expression of TNFAIP8ProteinHetionet hetionet:regulates:6722-25816Inferred only

Other names

7 names

Resolves to: TNFAIP8

Also called: Head and neck tumor and metastasis-related proteinMDC-3.13NDEDNF-kappa-B-inducible DED-containing proteinSCC-S2TNF alpha-induced protein 8TNF-induced protein GG2-1

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