Proteins/UNIPROT:O94886

TMEM63A

ProteinUNIPROT:O94886

Mechanosensitive cation channel with low conductance and high activation threshold. In contrast to TMEM63B, does not show phospholipid scramblase activity. Acts as a regulator of lysosomal morphology by mediating lysosomal mechanosensitivity (By similarity). Important for the baby's first breath and respiration throughout life. Upon lung inflation conducts cation currents in alveolar type 1 and 2 cells triggering lamellar body exocytosis and surfactant secretion into airspace. Also acts as an osmosensitive cation channel preferentially activated by hypotonic stress (By similarity)..

Function from UniProtKB (O94886), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

leukodystrophy, hypomyelinating, 19, transient infantile has a germline basis in TMEM63ADiseaseGenCC HGNC:29118|MONDO:0032871Inferred only

Statements

7 statements

7 statements · 3 reference databases · Subject: TMEM63A · Sources: Hetionet, Reactome, Rhea

Order

KRT9 covaries with TMEM63AProteinHetionet hetionet:covaries:3857-9725Inferred only
EEF1D interacts with TMEM63AProteinHetionet hetionet:interacts:1936-9725Inferred only
UBC interacts with TMEM63AProteinHetionet hetionet:interacts:7316-9725Inferred only
TMEM63A participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
TMEM63A participates in Innate Immune SystemPathwayReactome R-HSA-168249Inferred only
TMEM63A participates in Neutrophil degranulationPathwayReactome R-HSA-6798695Inferred only
Ca(2+) is transported by TMEM63ACompoundRhea RHEA:29671Inferred only

Reactions

1 reaction

Ca(2+)Ca(2+)
Transported by ANO9 or HTR3E or TMEM150C or CACNA1A or GRIN2D or P2RX6 or GRID2 or CACNA1G or GRIN3B or CACNA1F or TRPA1 or TRPM2 and 106 more alternatives
Reaction pageRight to leftBalanced
Rhea RHEA:29671CC BY 4.0Reference data

Other names

4 names

Resolves to: TMEM63A

Also called: hTMEM63AKIAA0489KIAA0792Transmembrane protein 63A

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