Proteins/UNIPROT:Q6N022

TENM4

ProteinUNIPROT:Q6N022

Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Plays a role in the establishment of the anterior-posterior axis during gastrulation. Regulates the differentiation and cellular process formation of oligodendrocytes and myelination of small-diameter axons in the central nervous system (CNS). Promotes activation of focal adhesion kinase. May function as a cellular signal transducer (By similarity)..

Function from UniProtKB (Q6N022), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

tremor, hereditary essential, 5 has a germline basis in TENM4DiseaseGenCC HGNC:29945|MONDO:0014756Inferred only

Statements

16 statements

16 statements · 2 reference databases · Subject: TENM4 · Sources: gene ontology, Hetionet

Order

HOXC12 covaries with TENM4ProteinHetionet hetionet:covaries:26011-3228Inferred only
TENM4 interacts with CAND1ProteinHetionet hetionet:interacts:26011-55832Inferred only
TENM4 regulates positive regulation of gastrulationBiological processgene ontology Q6N022|GO:2000543Inferred only
TENM4 regulates positive regulation of myelinationBiological processgene ontology Q6N022|GO:0031643Inferred only
TENM4 regulates positive regulation of oligodendrocyte differentiationBiological processgene ontology Q6N022|GO:0048714Inferred only
TENM4 regulates regulation of myelinationBiological processgene ontology Q6N022|GO:0031641Inferred only
ALDH7A1 increases the expression of TENM4ProteinHetionet hetionet:regulates:501-26011Inferred only
ALDOC increases the expression of TENM4ProteinHetionet hetionet:regulates:230-26011Inferred only
CCND3 increases the expression of TENM4ProteinHetionet hetionet:regulates:896-26011Inferred only
CYP51A1 increases the expression of TENM4ProteinHetionet hetionet:regulates:1595-26011Inferred only
IGFBP2 increases the expression of TENM4ProteinHetionet hetionet:regulates:3485-26011Inferred only
PTMS increases the expression of TENM4ProteinHetionet hetionet:regulates:5763-26011Inferred only

Show the remaining 4

PUF60 decreases the expression of TENM4ProteinHetionet hetionet:regulates:22827-26011Inferred only
RAC1 increases the expression of TENM4ProteinHetionet hetionet:regulates:5879-26011Inferred only
RASSF2 increases the expression of TENM4ProteinHetionet hetionet:regulates:9770-26011Inferred only
ZNF589 increases the expression of TENM4ProteinHetionet hetionet:regulates:51385-26011Inferred only

Other names

9 names

Resolves to: TENM4

Also called: KIAA1302Odd Oz/ten-m homolog 4ODZ4Protein Odd Oz/ten-m homolog 4Ten-4Ten-m4Tenascin-M4Teneurin transmembrane protein 4TNM4

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