tremor, hereditary essential, 5
Findings
No curated finding names tremor, hereditary essential, 5 yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Any essential tremor in which the cause of the disease is a mutation in the TENM4 gene.
Definition from the Mondo Disease Ontology (MONDO:0014756), read 2026-09-29. CC BY 4.0.
- Inheritance
- Autosomal dominant inheritance · Typified by incomplete penetrance · Typified by age-related disease onset
- Onset and course
- Late onset · Middle age onset · Juvenile onset · Slowly progressive · Young adult onset · Childhood onset
HPO, annotations 2026-09-02
Features
5 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Intention tremorHPOHP:0002080
- 16 of 16 reported patients
- Postural tremorHPOHP:0002174
- 18 of 18 reported patients
- Kinetic tremorHPOHP:0030186
- 7 of 8 reported patients
- Tongue tremorHPOHP:0031947
- 6 of 17 reported patients
- BradykinesiaHPOHP:0002067
- 0 of 15 reported patients
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- TENM4HGNC:29945
- Strong · Labcorp Genetics (formerly Invitae) · Autosomal dominant · 2023
- Moderate · Laboratory for Molecular Medicine · Autosomal dominant · 2020
- Limited · Ambry Genetics · Autosomal dominant · 2023
Where it sits
- A kind of
Other names
6 names
Resolves to: tremor, hereditary essential, 5
- Also called
- essential tremor caused by mutation in TENM4essential tremor, hereditary, 5ETM5TENM4 essential tremortremor, hereditary essential, 5; ETM5tremor, hereditary essential, type 5