SWSAP1

Single-stranded DNA-stimulated ATPase involved in DNA double-strand break (DSB) repair via homologous recombination (HR). Forms a heterodimeric complex with ZSWIM7/SWS1 that promotes HR by regulating replication protein-A (RPA) dynamics on single-stranded DNA, thereby stabilizing RAD51 and DMC1 filaments on DNA. The SWSAP1-ZSWIM7/SWS1 heterodimer is essential during meiosis by stabilizing DMC1 filaments (By similarity). In contrast, it is critical for only certain types of homologous-directed DNA repair, such as inter-homolog homologous recombination (IR-HR). IR-HR is a DNA repair mechanism where a cell repairs a DSB on one chromosome using the matching homologous chromosome as a template, rather than the sister chromatid. Also promotes homologous recombination by inactivating the FIGNL1-FIRRM complex to protect RAD51 filament from premature disassembly. Has a DNA-binding activity which is independent of its ATPase activity: preferentially binds DNA with an exposed 5' end..

Function from UniProtKB (Q6NVH7), read 2026-09-23. CC BY 4.0.