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Proteins/UNIPROT:Q19AV6
Involved in early stages DNA double-strand break (DSB) repair via homologous recombination (HR). Forms a heterodimeric complex with ZSWIM7/SWS1 that promotes HR by regulating replication protein-A (RPA) dynamics on single-stranded DNA, thereby stabilizing RAD51 and DMC1 filaments on DNA. The SWSAP1-ZSWIM7/SWS1 heterodimer is essential during meiosis by stabilizing DMC1 filaments. In contrast, it is critical for only certain types of homologous-directed DNA repair, such as inter-homolog homologous recombination (IR-HR). IR-HR is a DNA repair mechanism where a cell repairs a DSB on one chromosome using the matching homologous chromosome as a template, rather than the sister chromatid..
Function from UniProtKB (Q19AV6), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
3 statements
3 statements · 1 reference database · Subject: ZSWIM7 · Sources: Hetionet
3 names
Resolves to: ZSWIM7