Proteins/UNIPROT:P0C7P3

SLFN14

ProteinUNIPROT:P0C7P3

[Protein SLFN14]: Shows no ribosome-associated and endoribonuclease activities..

[C-terminally truncated SLFN14 endoribonuclease]: Displays polysome-associated endoribonuclease activity towards mRNAs and rRNAs. May play a role in RNA surveillance pathways by recognizing stalled ribosomes and triggering endonucleolytic cleavage of aberrant mRNAs (Probable). Cleaves different types of rRNAs and mRNAs in a magnesium- and manganese-dependent and ATP-independent manner (By similarity). Involved in correct maturation of megakaryocytes and especially important for proplatelet extension..

Function from UniProtKB (P0C7P3), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

platelet-type bleeding disorder 20 has a germline basis in SLFN14DiseaseGenCC HGNC:32689|MONDO:0014830Inferred only

Statements

8 statements

8 statements · 3 reference databases · Subject: SLFN14 · Sources: Hetionet, UniProt, WikiPathways

Order

SLFN14 covaries with IL4RProteinHetionet hetionet:covaries:342618-3566Inferred only
SLFN14 covaries with MFSD6LProteinHetionet hetionet:covaries:162387-342618Inferred only
SLFN14 covaries with PPP1R18ProteinHetionet hetionet:covaries:170954-342618Inferred only
SLFN14 covaries with SPTBN5ProteinHetionet hetionet:covaries:342618-51332Inferred only
SLFN14 covaries with TRMT5ProteinHetionet hetionet:covaries:342618-57570Inferred only
SLFN14 participates in 17q12 copy number variation syndromePathwayWikiPathways WP5287Inferred only
SLFN14 requires the cofactor magnesium(2+)CompoundUniProt P0C7P3Inferred only
SLFN14 requires the cofactor Mn(2+)CompoundUniProt P0C7P3Inferred only

Other names

2 names

Resolves to: SLFN14

Also called: ]Schlafen family member 14

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