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Proteins/UNIPROT:Q969S0
Antiporter that transports nucleotide sugars across the endoplasmic reticulum (ER) membrane in exchange for another nucleotide sugar. May couple UDP-alpha-D-glucuronate (UDP-GlcA) or UDP-alpha-D-xylose (UDP-Xyl) efflux to UDP-alpha-D-glucuronate (UDP-GlcA) influx into the ER lumen, which in turn stimulates glucuronidation and excretion of endobiotics and xenobiotics..
[Isoform 1]: Has UDP-GlcA:UDP-GlcNAc antiporter activity..
[Isoform 2]: Has UDP-GlcA:UDP-GlcNAc antiporter activity..
Function from UniProtKB (Q969S0), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
11 statements
11 statements · 4 reference databases · Subject: SLC35B4 · Sources: Hetionet, Human-GEM, Reactome, Rhea
3 reactions
CHEBI:67119+UMPCHEBI:67119+UMP
Transported by SLC35B4
Reaction pageReversibleBalancedcytosol, Golgi apparatus
Human-GEM MAR00918CC BY 4.0Reference data
UDP-N-acetyl-alpha-D-glucosamine+UDP-alpha-D-glucuronateUDP-N-acetyl-alpha-D-glucosamine+UDP-alpha-D-glucuronate
4 names
Resolves to: SLC35B4
Rhea RHEA:73703CC BY 4.0Reference data
UDP-alpha-D-xylose+UDP-alpha-D-glucuronateUDP-alpha-D-xylose+UDP-alpha-D-glucuronate
Transported by SLC35B4
Reaction pageLeft to rightBalanced
Rhea RHEA:74831CC BY 4.0Reference data