Skip to content

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:Q8TEJ3

SH3RF3

Protein·UNIPROT:Q8TEJ3

Open in the graph

Has E3 ubiquitin-protein ligase activity..

Function from UniProtKB (Q8TEJ3), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

6 statements

6 statements · 2 reference databases · Subject: SH3RF3 · Sources: gene ontology, Hetionet

Search this listOrder

SH3RF3 covaries with OR8I2ProteinHetionet hetionet:covaries:120586-344558Inferred only
ADAM15 interacts with SH3RF3ProteinHetionet hetionet:interacts:344558-8751Inferred only
PAK2 interacts with SH3RF3ProteinHetionet hetionet:interacts:344558-5062Inferred only
RAC1 interacts with SH3RF3ProteinHetionet hetionet:interacts:344558-5879Inferred only
SH3RF3 regulates negative regulation of apoptotic processBiological processgene ontology Q8TEJ3|GO:0043066Inferred only
SH3RF3 regulates positive regulation of JNK cascadeBiological processgene ontology Q8TEJ3|GO:0046330Inferred only

Reactions

1 reaction

MAM00204c+ATP+MAM03105cMAM00214c+AMP+diphosphate(3-)
Catalysed by RNF40 & RNF20 or SAE1 & UBA2 or RING1 & RNF2 or HECW1 or MYCBP2 or MYLIP or UBE3C or RNF216 or UBR7 or RNF14 or UBR2

Other names

5 names

Resolves to: SH3RF3

Also called: Plenty of SH3s 2POSH2SH3 domain-containing RING finger protein 3SH3 multiple domains protein 4SH3MD4

← Every protein Find it in the graph →

or UBA6

and 160 more alternatives

Reaction pageLeft to rightBalance undeterminableEC 2.3.2.23, 2.3.2.27, 6.2.1.45cytosol

Human-GEM MAR09491CC BY 4.0Reference data