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Proteins/UNIPROT:P58005
May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway. May also regulate the insulin-receptor signaling pathway through activation of TORC2 (By similarity). This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity). May prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity)..
Function from UniProtKB (P58005), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
27 statements
27 statements · 6 reference databases · Subject: SESN3 · Sources: Bgee, gene ontology, Hetionet, Reactome, Rhea, WikiPathways
1 reaction
a hydroperoxide+L-cysteinyl-[protein]S-hydroxy-L-cysteinyl-[protein]+an alcohol
Catalysed by SESN2 or SESN3 or SESN1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:67124CC BY 4.0Reference data
2 names
Resolves to: SESN3